NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	MU520_RS05370	Genome accession	NZ_CP095463
Coordinates	1089272..1089943 (+)	Length	223 a.a.
NCBI ID	WP_014637852.1	Uniprot ID	G7SGW2
Organism	Streptococcus suis strain TJS56
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1084272..1094943

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MU520_RS05340	pstC	1084488..1085405 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
MU520_RS05345	pstA	1085395..1086282 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
MU520_RS05350	pstB	1086307..1087110 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
MU520_RS05355	pstB	1087122..1087880 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
MU520_RS05360	phoU	1087909..1088565 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
MU520_RS05365	-	1088731..1089078 (+)	348	WP_014635995.1	hypothetical protein	-
MU520_RS05370	ciaR	1089272..1089943 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
MU520_RS05375	ciaH	1089936..1091315 (+)	1380	WP_024409447.1	HAMP domain-containing sensor histidine kinase	Regulator
MU520_RS05380	-	1091416..1092645 (+)	1230	WP_014637854.1	transglutaminase domain-containing protein	-
MU520_RS05385	rpsT	1092908..1093156 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
MU520_RS05390	coaA	1093215..1094135 (-)	921	WP_002935283.1	type I pantothenate kinase	-
MU520_RS05395	-	1094244..1094834 (+)	591	WP_014637855.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25245.83 Da Isoelectric Point: 4.2183

                                >NTDB_id=677008 MU520_RS05370 WP_014637852.1 1089272..1089943(+) (ciaR) [Streptococcus suis strain TJS56]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA

KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY

FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

Download Length: 672 bp

                                >NTDB_id=677008 MU520_RS05370 WP_014637852.1 1089272..1089943(+) (ciaR) [Streptococcus suis strain TJS56]

ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT

TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT

TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC

AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA

ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG

TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC

TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT

TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC

GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	G7SGW2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368

Detailed information NTG0677008