Detailed information NTG0675106

Bioinformatically predicted

Overview

• Name: vicR
• Type: Regulator
• Locus tag: MP619_RS08365
• Genome accession: NZ_CP095081
• Coordinates: 1664989..1665699 (-)
• Length: 236 a.a.
• NCBI ID: WP_003049952.1
• Uniprot ID: A0A9X9SIG1
• Organism: Streptococcus dysgalactiae strain WJ001
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	1657539..1666752	1664989..1665699	within	0

Gene organization within MGE regions

Location: 1657539..1666752

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MP619_RS08330 (MP619_08300)	-	1657539..1658650 (+)	1112	WP_089180045.1	IS3-like element IS981 family transposase	-
MP619_RS08335 (MP619_08305)	-	1658661..1659092 (-)	432	WP_155782766.1	hypothetical protein	-
MP619_RS08340 (MP619_08310)	-	1659413..1660435 (-)	1023	WP_129555386.1	IS30 family transposase	-
MP619_RS08345 (MP619_08315)	-	1660627..1661738 (+)	1112	WP_089180045.1	IS3-like element IS981 family transposase	-
MP619_RS08350 (MP619_08320)	-	1661874..1662749 (+)	876	WP_129556026.1	helix-turn-helix transcriptional regulator	-
MP619_RS08355 (MP619_08325)	vicX	1662831..1663640 (-)	810	WP_129556027.1	MBL fold metallo-hydrolase	Regulator
MP619_RS08360 (MP619_08330)	vicK	1663644..1664996 (-)	1353	WP_155782777.1	cell wall metabolism sensor histidine kinase VicK	Regulator
MP619_RS08365 (MP619_08335)	vicR	1664989..1665699 (-)	711	WP_003049952.1	response regulator YycF	Regulator
MP619_RS08370 (MP619_08340)	-	1665958..1666752 (+)	795	WP_003057217.1	amino acid ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 236 a.a.
• Molecular weight: 27029.90 Da
• Isoelectric Point: 4.9981

>NTDB_id=675106 MP619_RS08365 WP_003049952.1 1664989..1665699(-) (vicR) [Streptococcus dysgalactiae strain WJ001]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTVFEDEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGSQELTIGNLQILPDAFVAKKHGKEVE
LTHREFELLHHLANHMGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide

• Length: 711 bp

>NTDB_id=675106 MP619_RS08365 WP_003049952.1 1664989..1665699(-) (vicR) [Streptococcus dysgalactiae strain WJ001]
ATGAAAAAAATACTGATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAACTTGACAAAAGAAGGTTATGA
CATTGTGACCGCTTTTGATGGCCGTGAAGCTGTTACCGTGTTTGAAGACGAAAAACCGGATTTAATTATTCTTGATTTGA
TGTTACCGGAATTGGACGGTCTTGAAGTGGCCAAAGAAATCCGTAAAACCAGTCATGTGCCGATTATTATGCTGTCGGCT
AAGGATAGTGAGTTTGACAAGGTCATTGGCCTTGAAATTGGGGCAGATGATTATGTTACCAAACCCTTTTCAAATCGTGA
ACTATTAGCGCGTGTCAAGGCTCATTTACGTCGAACAGAAACGATCGAAACAGCCGTAGCAGAGGAAAATGCTTCTTCAG
GTTCACAAGAGTTAACCATTGGTAATTTACAAATTTTACCAGATGCTTTTGTGGCTAAAAAACATGGCAAAGAAGTGGAA
TTAACCCATCGTGAATTTGAATTATTACACCACCTGGCCAATCATATGGGTCAAGTGATGACACGAGAGCACTTGCTTGA
GACGGTTTGGGGCTATGATTACTTTGGCGATGTCCGTACTGTTGACGTGACAGTTCGTCGTCTGCGTGAAAAAATTGAAG
ATACACCAAGCCGTCCCGAATATATTTTAACGAGACGCGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-113)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (156-231)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicR	Streptococcus mutans UA159	90.254	100	0.903
micA	Streptococcus pneumoniae Cp1015	79.487	99.153	0.788
covR	Lactococcus lactis subsp. lactis strain DGCC12653	44.828	98.305	0.441
covR	Streptococcus salivarius strain HSISS4	44.397	98.305	0.436
scnR	Streptococcus mutans UA159	37.712	100	0.377