Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   MP619_RS08360 Genome accession   NZ_CP095081
Coordinates   1663644..1664996 (-) Length   450 a.a.
NCBI ID   WP_155782777.1    Uniprot ID   -
Organism   Streptococcus dysgalactiae strain WJ001     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1657539..1666752 1663644..1664996 within 0


Gene organization within MGE regions


Location: 1657539..1666752
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MP619_RS08330 (MP619_08300) - 1657539..1658650 (+) 1112 WP_089180045.1 IS3-like element IS981 family transposase -
  MP619_RS08335 (MP619_08305) - 1658661..1659092 (-) 432 WP_155782766.1 hypothetical protein -
  MP619_RS08340 (MP619_08310) - 1659413..1660435 (-) 1023 WP_129555386.1 IS30 family transposase -
  MP619_RS08345 (MP619_08315) - 1660627..1661738 (+) 1112 WP_089180045.1 IS3-like element IS981 family transposase -
  MP619_RS08350 (MP619_08320) - 1661874..1662749 (+) 876 WP_129556026.1 helix-turn-helix transcriptional regulator -
  MP619_RS08355 (MP619_08325) vicX 1662831..1663640 (-) 810 WP_129556027.1 MBL fold metallo-hydrolase Regulator
  MP619_RS08360 (MP619_08330) vicK 1663644..1664996 (-) 1353 WP_155782777.1 cell wall metabolism sensor histidine kinase VicK Regulator
  MP619_RS08365 (MP619_08335) vicR 1664989..1665699 (-) 711 WP_003049952.1 response regulator YycF Regulator
  MP619_RS08370 (MP619_08340) - 1665958..1666752 (+) 795 WP_003057217.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 450 a.a.        Molecular weight: 51461.99 Da        Isoelectric Point: 5.5536

>NTDB_id=675105 MP619_RS08360 WP_155782777.1 1663644..1664996(-) (vicK) [Streptococcus dysgalactiae strain WJ001]
MTRDIIGNLSAFELAILLLLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDMINEKADIELMELADQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLTKEQALEKNITDLLEGDTPYTYRELVSKTPV
VTVNSRNDMGEFVTLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLSVEMTNFTAFMTSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYDEWEDDID

Nucleotide


Download         Length: 1353 bp        

>NTDB_id=675105 MP619_RS08360 WP_155782777.1 1663644..1664996(-) (vicK) [Streptococcus dysgalactiae strain WJ001]
ATGACTAGAGATATCATCGGAAACTTATCCGCTTTTGAATTAGCGATTCTCTTATTACTTGTTTTTGTTGCCTTTTATTT
TATTCACTTAGCGGTGCGTGATTACCGAAATGCCCGTATTATTCGAATGATGAGCCATAAAATCAGAGACCTGATTAATG
GCCGTTATACCGACATGATTAACGAAAAGGCTGACATTGAATTGATGGAACTGGCAGATCAGTTAAACGATCTCTCAGAC
GTGTTTCGCTTAACCCATGAGAATCTTGCTCAGGAAAAAAATCGCTTGGCCAGCATTCTGGCCTATATGTCAGATGGCGT
ACTTGCCACAGACCGTTCTGGGAAAATCATCATGATTAACGAGACTGCCCGCAAGCAGCTCAATCTGACCAAGGAGCAGG
CCCTTGAAAAGAACATTACCGATTTGTTGGAGGGAGATACCCCCTATACCTATCGTGAATTGGTTTCCAAAACGCCTGTT
GTGACGGTCAATAGTCGCAATGACATGGGTGAGTTTGTGACATTGCGTTTACGCTTCGCCTTAAACAGACGAGAAAGTGG
TTTTATTTCTGGTTTGGTTGTGGTGCTCCATGACACTACAGAACAGGAAAAGGAAGAACGTGAACGCCGGTTGTTTGTTT
CTAATGTGAGTCATGAGTTGAGAACTCCTTTGACATCGGTGAAATCCTACTTGGAGGCTCTTGACGAAGGTGCCCTCAAG
GAAGATATTGCCCCAAGTTTTATCAAGGTTTCTCTTGATGAAACCAATCGTATGATGCGAATGATTTCCGATCTTTTAAA
CTTGTCTCGCATTGATAACCAAGTAACTCAGTTATCTGTTGAGATGACCAATTTTACAGCTTTTATGACATCTATCCTGA
ACCGATTTGACCTAGTTAAAAACCAGCACACCGGTACTGGCAAGGTTTATGAAATTGTGAGAGACTATCCGATTACTTCT
GTTTGGCTGGAAATTGATAACGATAAGATGACGCAGGTTATTGAAAATATCCTAAACAACGCGATTAAATACTCTCCTGA
TGGTGGGAAAATCACTGTTCGCATGAAAACAACAGACACGCAATTGATTATTTCCATCTCAGACCAAGGTTTAGGCATTC
CGAAGAAGGACCTGCCCCTTATTTTTGACCGTTTTTACCGAGTGGACAAGGCAAGAAGCCGTGCTCAAGGTGGAACTGGT
CTAGGGCTTGCCATTGCCAAAGAAATTATTAAGCAGCATCACGGGTTTATCTGGGCGAAGAGTGATTATGGCAAAGGATC
AACCTTTACCATCGTCTTGCCATATGAAAAAGATGCTGCCATTTACGACGAGTGGGAGGATGACATAGATTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(326-436)

His Kinase A (phospho-acceptor) domain (HisKA)

(209-273)

PAS fold (PAS)

(95-165)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.671

92

0.678
  micB Streptococcus pneumoniae Cp1015

66.824

94.444

0.631