Detailed information NTG0067258

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: SITYG_RS04660
• Genome accession: NZ_AP014880
• Coordinates: 930112..930786 (+)
• Length: 224 a.a.
• NCBI ID: WP_003036714.1
• Uniprot ID: -
• Organism: Streptococcus intermedius strain TYG1620
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 925112..935786

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SITYG_RS04625 (SITYG_09020)	-	925139..926449 (+)	1311	WP_096362804.1	type II restriction enzyme	-
SITYG_RS10425	-	926470..926640 (+)	171	WP_173672239.1	hypothetical protein	-
SITYG_RS10325 (SITYG_09030)	-	926822..926989 (+)	168	WP_158467588.1	hypothetical protein	-
SITYG_RS04630	-	927005..927340 (+)	336	WP_096362805.1	hypothetical protein	-
SITYG_RS10740 (SITYG_09050)	-	927791..927916 (+)	126	WP_269457688.1	hypothetical protein	-
SITYG_RS10590 (SITYG_09060)	-	927984..928128 (+)	145	Protein_889	site-specific integrase	-
SITYG_RS04650 (SITYG_09070)	-	928368..929108 (+)	741	WP_096362806.1	alpha/beta hydrolase	-
SITYG_RS04655 (SITYG_09080)	-	929407..929850 (+)	444	WP_096362807.1	hypothetical protein	-
SITYG_RS04660 (SITYG_09090)	ciaR	930112..930786 (+)	675	WP_003036714.1	response regulator transcription factor	Regulator
SITYG_RS04665 (SITYG_09100)	ciaH	930776..932122 (+)	1347	WP_082311553.1	sensor histidine kinase	Regulator
SITYG_RS04670 (SITYG_09110)	-	932398..933846 (-)	1449	WP_162287167.1	alpha-amylase	-
SITYG_RS04675 (SITYG_09120)	-	934216..934725 (-)	510	WP_096362809.1	DNA topology modulation protein	-
SITYG_RS04680 (SITYG_09130)	rpsT	934790..935026 (-)	237	WP_003072853.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25373.03 Da
• Isoelectric Point: 4.2408

>NTDB_id=67258 SITYG_RS04660 WP_003036714.1 930112..930786(+) (ciaR) [Streptococcus intermedius strain TYG1620]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide

• Length: 675 bp

>NTDB_id=67258 SITYG_RS04660 WP_003036714.1 930112..930786(+) (ciaR) [Streptococcus intermedius strain TYG1620]
ATGATTAAGATTCTATTAGTAGAAGATGACCTCGGTTTATCTAACTCAGTATTTGATTTTTTAGATGACTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCTGAAAGTGGTGTGTATGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGATGGTTTTCAAGTATTGAAGGAATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGGGCTGACGATTATTTAACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGGTCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGTGATGTAACCA
TTAATTTGTCAACGAACACTACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGCTTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAACCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	91.518	100	0.915
ciaR	Streptococcus pneumoniae D39	91.518	100	0.915
ciaR	Streptococcus pneumoniae R6	91.518	100	0.915
ciaR	Streptococcus pneumoniae TIGR4	91.518	100	0.915
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.207	100	0.397
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Streptococcus salivarius strain HSISS4	35.683	100	0.362