Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   SITYG_RS04665 Genome accession   NZ_AP014880
Coordinates   930776..932122 (+) Length   448 a.a.
NCBI ID   WP_082311553.1    Uniprot ID   A0AAE8KC83
Organism   Streptococcus intermedius strain TYG1620     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 925776..937122
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SITYG_RS10425 - 926470..926640 (+) 171 WP_173672239.1 hypothetical protein -
  SITYG_RS10325 (SITYG_09030) - 926822..926989 (+) 168 WP_158467588.1 hypothetical protein -
  SITYG_RS04630 - 927005..927340 (+) 336 WP_096362805.1 hypothetical protein -
  SITYG_RS10740 (SITYG_09050) - 927791..927916 (+) 126 WP_269457688.1 hypothetical protein -
  SITYG_RS10590 (SITYG_09060) - 927984..928128 (+) 145 Protein_889 site-specific integrase -
  SITYG_RS04650 (SITYG_09070) - 928368..929108 (+) 741 WP_096362806.1 alpha/beta hydrolase -
  SITYG_RS04655 (SITYG_09080) - 929407..929850 (+) 444 WP_096362807.1 hypothetical protein -
  SITYG_RS04660 (SITYG_09090) ciaR 930112..930786 (+) 675 WP_003036714.1 response regulator transcription factor Regulator
  SITYG_RS04665 (SITYG_09100) ciaH 930776..932122 (+) 1347 WP_082311553.1 sensor histidine kinase Regulator
  SITYG_RS04670 (SITYG_09110) - 932398..933846 (-) 1449 WP_162287167.1 alpha-amylase -
  SITYG_RS04675 (SITYG_09120) - 934216..934725 (-) 510 WP_096362809.1 DNA topology modulation protein -
  SITYG_RS04680 (SITYG_09130) rpsT 934790..935026 (-) 237 WP_003072853.1 30S ribosomal protein S20 -
  SITYG_RS04685 (SITYG_09140) coaA 935095..936015 (-) 921 WP_096362810.1 type I pantothenate kinase -
  SITYG_RS04690 (SITYG_09150) - 936108..936701 (+) 594 WP_021002769.1 class I SAM-dependent methyltransferase -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50922.71 Da        Isoelectric Point: 10.1689

>NTDB_id=67259 SITYG_RS04665 WP_082311553.1 930776..932122(+) (ciaH) [Streptococcus intermedius strain TYG1620]
MLNKLKKAWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLEQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKSIITSNNFLGFNKLSFNSKQLDRIRQIQVKSNYGREETYRMVLFQVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDIEPNFFNTTFTNYEMVATENGKVFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIVVKDNKPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=67259 SITYG_RS04665 WP_082311553.1 930776..932122(+) (ciaH) [Streptococcus intermedius strain TYG1620]
ATGCTGAATAAACTAAAAAAAGCATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAATAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCGCTTGCTCGAAAAGTAGGGCTAGAGCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGATAAAGAGCTGACAGATAAACCAAATGTGAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAATCAATTATTACAAGCAATAATTTTTTAGGGTTTAATAAACTTTCCTTTAATAGCAAGCAATTAGATCGTA
TTCGTCAAATTCAAGTAAAAAGTAATTACGGCCGAGAAGAAACCTATCGGATGGTTTTGTTTCAAGTGAAATTGCCTAAT
TTAGAAACCAATGTCAAATACGCAGCAGTTTTTATCAATATTAGCCAATTGGAACAAACTAGTCAAAACCATGAACAGTT
GATTGTAGTTGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTCTATCTTGCGCGAGTAAGTGTCAAACCGC
TTTTGGAAAGTATTCAAAAACAAAAGAGCTTTGTCGAAAATGCTAGTCATGAATTACGCACACCTTTAGCCGTTTTGCAA
AATCGTTTGGAGACTTTGTTTAGAAAACCAGAAGCTACTATTATGGAATCGAGTGAAAGCATCGCTTCTAGTTTAGATGA
AGTGCGAAACATGAAAATGTTGACAACGAACTTACTTAATTTAGCACGGCGTGATGATGGGATTAAACCAGAGATTGGTG
ATATTGAACCCAATTTCTTTAATACGACCTTTACGAACTATGAAATGGTTGCCACAGAAAATGGAAAAGTTTTTCGATTT
GACAATAGGATTCATCGTGTGATAAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTATTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTGAAGGTTTCGGATA
ATGGTCCAGGGATTAGTACAGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCTCGGACTCGACAG
ACAGGTGGTTTTGGTTTAGGGTTGTCACTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGTAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.312

100

0.703
  ciaH Streptococcus pneumoniae D39

70.312

100

0.703
  ciaH Streptococcus pneumoniae R6

70.312

100

0.703
  ciaH Streptococcus pneumoniae TIGR4

70.312

100

0.703
  ciaH Streptococcus mutans UA159

55.708

97.768

0.545

Multiple sequence alignment