Detailed information NTG0672155

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: MUA94_RS04210
• Genome accession: NZ_CP094768
• Coordinates: 853539..854582 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IVB6202
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 848539..859582

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MUA94_RS04180 (MUA94_04175)	-	849090..849202 (+)	113	Protein_820	hypothetical protein	-
MUA94_RS04185 (MUA94_04180)	-	849231..849644 (+)	414	WP_262538798.1	hypothetical protein	-
MUA94_RS04190 (MUA94_04185)	-	850009..850995 (-)	987	WP_262538478.1	aromatic acid exporter family protein	-
MUA94_RS04195 (MUA94_04190)	map	851465..852223 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
MUA94_RS04200 (MUA94_04195)	-	852440..852826 (+)	387	WP_001110179.1	hypothetical protein	-
MUA94_RS04205 (MUA94_04200)	liaF	852841..853542 (+)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
MUA94_RS04210 (MUA94_04205)	vraS	853539..854582 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
MUA94_RS04215 (MUA94_04210)	vraR	854572..855201 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
MUA94_RS04220 (MUA94_04215)	-	855317..856534 (-)	1218	WP_000037088.1	YihY/virulence factor BrkB family protein	-
MUA94_RS04225 (MUA94_04220)	-	856812..857087 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
MUA94_RS04230 (MUA94_04225)	-	857094..857558 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
MUA94_RS04235 (MUA94_04230)	-	857705..857905 (+)	201	WP_000180462.1	DUF1128 family protein	-
MUA94_RS04240 (MUA94_04235)	-	857908..859164 (+)	1257	WP_262538480.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=672155 MUA94_RS04210 WP_001017131.1 853539..854582(+) (vraS) [Staphylococcus aureus strain IVB6202]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=672155 MUA94_RS04210 WP_001017131.1 853539..854582(+) (vraS) [Staphylococcus aureus strain IVB6202]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCTCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1