Detailed information NTG0066600

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: SCSC_RS09390
• Genome accession: NZ_AP014647
• Coordinates: 1899565..1900755 (+)
• Length: 396 a.a.
• NCBI ID: WP_006270334.1
• Uniprot ID: U2XXY1
• Organism: Streptococcus constellatus subsp. constellatus strain CCUG 24889
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1894565..1905755

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCSC_RS09365 (SCSC_1930)	comE	1896361..1897110 (-)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
SCSC_RS09370 (SCSC_1931)	comD/comD2	1897110..1898435 (-)	1326	WP_280523174.1	GHKL domain-containing protein	Regulator
SCSC_RS09375 (SCSC_1932)	-	1898452..1898598 (-)	147	WP_006270349.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCSC_RS09385 (SCSC_1934)	rlmH	1898881..1899360 (-)	480	WP_006270335.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SCSC_RS09390 (SCSC_1935)	htrA	1899565..1900755 (+)	1191	WP_006270334.1	trypsin-like peptidase domain-containing protein	Regulator
SCSC_RS09395 (SCSC_1936)	spo0J	1900810..1901577 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 396 a.a.
• Molecular weight: 41637.72 Da
• Isoelectric Point: 9.8633

>NTDB_id=66600 SCSC_RS09390 WP_006270334.1 1899565..1900755(+) (htrA) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSNSDLSRLKLPSKVTSGV
VVRSAQAGMPAAGKLQKYDVITKVDGKDISSVSDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide

• Length: 1191 bp

>NTDB_id=66600 SCSC_RS09390 WP_006270334.1 1899565..1900755(+) (htrA) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCCACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTGGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAACAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAGTTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACTATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATTGCTAGCAACGGTGGAACTTCTGTTGAGGGATTAGGTTT
TGCCATTCCATCTAATGATGTTATTAATATTATCAATCAATTAGAAGCAAACGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATCGACATCACTAATCTGTCTAATTCAGATTTATCACGCTTAAAACTCCCATCCAAAGTAACTAGTGGGGTT
GTTGTACGTTCAGCTCAAGCTGGGATGCCTGCAGCAGGAAAGCTTCAAAAATATGATGTTATTACAAAAGTAGATGGCAA
AGACATTTCCTCAGTAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACAACTACTATTAAGCTGACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (104-249)

• PDZ domain (PDZ_2) (290-385)

• Peptidase family M50 (Peptidase_M50) (266-390)

3D structure

• AlphaFold DB: U2XXY1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	74.25	100	0.75
htrA	Streptococcus mitis NCTC 12261	72.292	100	0.725
htrA	Streptococcus pneumoniae R6	72.04	100	0.722
htrA	Streptococcus pneumoniae TIGR4	72.04	100	0.722
htrA	Streptococcus pneumoniae D39	72.04	100	0.722
htrA	Streptococcus pneumoniae Rx1	72.04	100	0.722
htrA	Streptococcus mutans UA159	55.838	99.495	0.556