Detailed information NTG0066598

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SCSC_RS09365
• Genome accession: NZ_AP014647
• Coordinates: 1896361..1897110 (-)
• Length: 249 a.a.
• NCBI ID: WP_003071650.1
• Uniprot ID: A0A380L579
• Organism: Streptococcus constellatus subsp. constellatus strain CCUG 24889
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1891361..1902110

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCSC_RS09345 (SCSC_1926)	-	1891766..1893388 (+)	1623	WP_006270327.1	ATP-binding cassette domain-containing protein	-
SCSC_RS09350 (SCSC_1927)	-	1893462..1896041 (+)	2580	WP_006270322.1	YfhO family protein	-
SCSC_RS09365 (SCSC_1930)	comE	1896361..1897110 (-)	750	WP_003071650.1	competence system response regulator transcription factor ComE	Regulator
SCSC_RS09370 (SCSC_1931)	comD/comD2	1897110..1898435 (-)	1326	WP_280523174.1	GHKL domain-containing protein	Regulator
SCSC_RS09375 (SCSC_1932)	-	1898452..1898598 (-)	147	WP_006270349.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCSC_RS09385 (SCSC_1934)	rlmH	1898881..1899360 (-)	480	WP_006270335.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SCSC_RS09390 (SCSC_1935)	htrA	1899565..1900755 (+)	1191	WP_006270334.1	trypsin-like peptidase domain-containing protein	Regulator
SCSC_RS09395 (SCSC_1936)	spo0J	1900810..1901577 (+)	768	WP_003071657.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 249 a.a.
• Molecular weight: 29171.69 Da
• Isoelectric Point: 8.0453

>NTDB_id=66598 SCSC_RS09365 WP_003071650.1 1896361..1897110(-) (comE) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MKVLILEDEITHQVRMETTLAEIAKEMGIPIKVKITGKVREFKEYIENDEVNQLYFLDIDIKGEETKGLEIAKFIRHHNP
YAIIVFVTTKSEFATMTFKYKVSALDFVDKNLNDAAFKKHIKDSIEYTKATLIENKDMVDYFEYSFRGGEVRMPFNDILY
IETTGSSHKLRIVGKNFFKEFYGTIADIQEKDEKTQRFFSPHKSYLVNIGNIKGYDKKTREIIFYEDHRCPITRMKIGKL
KSILEESKG

Nucleotide

• Length: 750 bp

>NTDB_id=66598 SCSC_RS09365 WP_003071650.1 1896361..1897110(-) (comE) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGAAAGTACTAATATTAGAAGATGAAATTACACATCAAGTTAGAATGGAAACAACATTGGCAGAAATAGCTAAGGAAAT
GGGGATTCCGATAAAAGTTAAAATAACTGGAAAAGTAAGAGAATTTAAAGAATATATTGAAAACGATGAAGTAAATCAAT
TATATTTTTTAGATATTGATATTAAAGGTGAAGAAACAAAAGGGTTAGAAATAGCCAAATTTATACGGCATCATAATCCT
TATGCCATTATTGTTTTTGTTACAACAAAATCAGAATTTGCTACTATGACGTTTAAATATAAAGTATCTGCATTGGATTT
TGTTGATAAAAATTTGAATGATGCTGCTTTTAAAAAACATATAAAAGACAGTATTGAATATACAAAAGCAACGTTGATTG
AAAATAAAGATATGGTTGATTATTTTGAATATAGTTTCCGTGGTGGCGAAGTTAGAATGCCTTTTAATGATATTTTATAT
ATTGAAACGACAGGTTCTTCTCATAAATTAAGAATTGTTGGTAAAAACTTTTTTAAAGAATTTTATGGTACGATTGCAGA
TATTCAGGAAAAAGACGAGAAAACACAGCGCTTCTTTTCACCTCATAAATCTTATCTAGTTAATATTGGGAATATTAAAG
GTTATGATAAAAAAACAAGAGAAATTATTTTTTATGAAGATCACCGTTGTCCGATTACTCGAATGAAAATTGGAAAGTTG
AAATCCATTTTAGAGGAATCAAAAGGATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-121)

• LytTr DNA-binding domain (LytTR) (152-244)

3D structure

• AlphaFold DB: A0A380L579

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus mitis NCTC 12261	71.837	98.394	0.707
comE	Streptococcus infantis strain Atu-4	71.02	98.394	0.699
comE	Streptococcus mitis SK321	71.02	98.394	0.699
comE	Streptococcus pneumoniae Rx1	70.612	98.394	0.695
comE	Streptococcus pneumoniae D39	70.612	98.394	0.695
comE	Streptococcus pneumoniae R6	70.612	98.394	0.695
comE	Streptococcus pneumoniae TIGR4	70.612	98.394	0.695
comE/comE2	Streptococcus gordonii strain NCTC7865	69.672	97.992	0.683
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	69.672	97.992	0.683
comE/blpR	Streptococcus mutans UA159	39.759	100	0.398
comE/comE2	Streptococcus equinus JB1	35.019	100	0.361