NTDB

Overview

Name	covR	Type	Regulator
Locus tag	MO978_RS07990	Genome accession	NZ_CP093959
Coordinates	1607496..1608188 (-)	Length	230 a.a.
NCBI ID	WP_003130756.1	Uniprot ID	S6EZK2
Organism	Lactococcus lactis strain FAM 17919
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1602496..1613188

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MO978_RS07975 (MO978_07980)	-	1604116..1604457 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
MO978_RS07980 (MO978_07985)	-	1604589..1605830 (-)	1242	WP_289421445.1	ammonium transporter	-
MO978_RS07985 (MO978_07990)	covS	1606013..1607488 (-)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
MO978_RS07990 (MO978_07995)	covR	1607496..1608188 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
MO978_RS07995 (MO978_08000)	-	1608344..1608874 (-)	531	WP_003130758.1	DUF177 domain-containing protein	-
MO978_RS08000 (MO978_08005)	-	1609005..1609250 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
MO978_RS08005 (MO978_08010)	-	1609406..1609870 (-)	465	WP_003130761.1	hypothetical protein	-
MO978_RS08010 (MO978_08015)	-	1609952..1610314 (-)	363	WP_010906050.1	TIGR02328 family protein	-
MO978_RS08015 (MO978_08020)	-	1610799..1611329 (-)	531	WP_003130764.1	CHAP domain-containing protein	-
MO978_RS08020 (MO978_08025)	-	1611390..1612226 (-)	837	WP_003130766.1	metallophosphoesterase	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26684.36 Da Isoelectric Point: 5.1273

                                >NTDB_id=665938 MO978_RS07990 WP_003130756.1 1607496..1608188(-) (covR) [Lactococcus lactis strain FAM 17919]

MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEATSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=665938 MO978_RS07990 WP_003130756.1 1607496..1608188(-) (covR) [Lactococcus lactis strain FAM 17919]

ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG

CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAACTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCCCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG

ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT

TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT

CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACAGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG

TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA

GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-115)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	S6EZK2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0665938