Detailed information NTG0066555

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SCSC_RS02745
• Genome accession: NZ_AP014647
• Coordinates: 543971..544717 (-)
• Length: 248 a.a.
• NCBI ID: WP_006270174.1
• Uniprot ID: A0AAD2Y4H7
• Organism: Streptococcus constellatus subsp. constellatus strain CCUG 24889
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 538971..549717

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCSC_RS02730 (SCSC_0562)	-	541010..542371 (+)	1362	WP_006270117.1	bacteriocin secretion accessory protein	-
SCSC_RS02735 (SCSC_0563)	-	542465..542614 (+)	150	WP_003025431.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
SCSC_RS02740	-	542659..543480 (-)	822	WP_232565280.1	GHKL domain-containing protein	-
SCSC_RS02745 (SCSC_0565)	comE/blpR	543971..544717 (-)	747	WP_006270174.1	response regulator transcription factor	Regulator
SCSC_RS02750 (SCSC_0566)	-	544886..545599 (-)	714	WP_006270152.1	type II CAAX endopeptidase family protein	-
SCSC_RS02755 (SCSC_0567)	-	545831..546052 (+)	222	WP_006267535.1	Blp family class II bacteriocin	-
SCSC_RS02760	-	546729..547049 (+)	321	WP_006270150.1	hypothetical protein	-
SCSC_RS09460	-	547057..547275 (+)	219	Protein_523	garvicin Q family class II bacteriocin	-
SCSC_RS02765 (SCSC_0571)	-	547342..547632 (+)	291	WP_006270118.1	bacteriocin immunity protein	-
SCSC_RS02770 (SCSC_0572)	-	547782..548102 (+)	321	WP_006270149.1	hypothetical protein	-
SCSC_RS02775 (SCSC_0573)	-	548332..548562 (+)	231	WP_006270136.1	Blp family class II bacteriocin	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28744.16 Da
• Isoelectric Point: 7.0486

>NTDB_id=66555 SCSC_RS02745 WP_006270174.1 543971..544717(-) (comE/blpR) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
MNIFILEDDLTQQYYMETIVEEIIEKHHLQYHHFEVVGKPKQLLEAISEKGSHQIFFLDIEIKTEEEKGLDVAKKIREID
PYAIIVFVTSHSELMPTAFKLQVGALDYLDKSLSKEIFKKRIETALLHTESLTGKGLADDALLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLLDILKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLVSRSKIKGLTEA
IAALHRRE

Nucleotide

• Length: 747 bp

>NTDB_id=66555 SCSC_RS02745 WP_006270174.1 543971..544717(-) (comE/blpR) [Streptococcus constellatus subsp. constellatus strain CCUG 24889]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCATCTTCAATATCATCATTTTGAAGTTGTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGATTTTCTTTTTAGACATTGAAATCAAAACCGAGGAAGAAAAGGGCTTAGACGTTGCTAAAAAGATACGCGAGATAGAT
CCTTATGCCATCATTGTCTTTGTAACCAGTCATTCTGAATTGATGCCTACAGCGTTTAAGCTGCAAGTGGGTGCCCTTGA
TTATCTTGACAAATCGTTATCAAAAGAAATCTTTAAAAAACGGATCGAAACTGCACTGCTACATACTGAAAGCCTAACAG
GTAAAGGGCTGGCAGACGATGCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCATTTAAAGATATTCTTTAT
ATTGAAACTTCCTCTCGTCCTCACCGCTTAGTTCTTTACACACATAGAGGACGTACGGAATTTACTGCTAATCTTTTAGA
TATTTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGCTCCTTTGTTGTTAATCCAGCTAATGTCCATCAAGTGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTGTTTCTAGATCAAAAATAAAAGGGTTAACAGAAGCC
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	49.798	99.597	0.496
comE/comE1	Streptococcus equinus JB1	44.726	95.565	0.427
comE	Streptococcus pneumoniae Rx1	36.992	99.194	0.367
comE	Streptococcus pneumoniae D39	36.992	99.194	0.367
comE	Streptococcus pneumoniae R6	36.992	99.194	0.367
comE	Streptococcus pneumoniae TIGR4	36.992	99.194	0.367
comE	Streptococcus mitis NCTC 12261	36.992	99.194	0.367
comE	Streptococcus mitis SK321	36.992	99.194	0.367
comE	Streptococcus infantis strain Atu-4	36.585	99.194	0.363