Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ANG_RS05895 Genome accession   NZ_AP013072
Coordinates   1164885..1165559 (-) Length   224 a.a.
NCBI ID   WP_003036714.1    Uniprot ID   -
Organism   Streptococcus anginosus subsp. whileyi MAS624     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1159885..1170559
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ANG_RS05880 (ANG_1186) - 1159920..1161533 (-) 1614 WP_020999625.1 M20/M25/M40 family metallo-hydrolase -
  ANG_RS05885 (ANG_1187) - 1161710..1163158 (+) 1449 WP_003036764.1 alpha-amylase -
  ANG_RS05890 (ANG_1188) ciaH 1163549..1164895 (-) 1347 WP_003036710.1 sensor histidine kinase Regulator
  ANG_RS05895 (ANG_1189) ciaR 1164885..1165559 (-) 675 WP_003036714.1 response regulator transcription factor Regulator
  ANG_RS05900 (ANG_1190) - 1165834..1166289 (-) 456 WP_003036769.1 hypothetical protein -
  ANG_RS05905 (ANG_1191) - 1166626..1167369 (-) 744 WP_003036850.1 alpha/beta fold hydrolase -
  ANG_RS05910 (ANG_1192) - 1167829..1168077 (+) 249 WP_025271788.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  ANG_RS05915 (ANG_1193) - 1168074..1168370 (+) 297 WP_003024343.1 type II toxin-antitoxin system RelE family toxin -
  ANG_RS05920 (ANG_1194) - 1168501..1169199 (-) 699 WP_003038287.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25373.03 Da        Isoelectric Point: 4.2408

>NTDB_id=65521 ANG_RS05895 WP_003036714.1 1164885..1165559(-) (ciaR) [Streptococcus anginosus subsp. whileyi MAS624]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=65521 ANG_RS05895 WP_003036714.1 1164885..1165559(-) (ciaR) [Streptococcus anginosus subsp. whileyi MAS624]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATCTTGCTTGATCTGATGT
TGCCAGAAAAAGACGGTTTCCAAGTATTGAAAGAATTGCGTGAAAAAGGCGTTACCACACCTGTTTTGATTATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGAGCTGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTCACTA
TTAATTTATCAACAAACACTACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GTAGTGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.518

100

0.915
  ciaR Streptococcus pneumoniae D39

91.518

100

0.915
  ciaR Streptococcus pneumoniae R6

91.518

100

0.915
  ciaR Streptococcus pneumoniae TIGR4

91.518

100

0.915
  ciaR Streptococcus mutans UA159

89.686

99.554

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment