Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ANG_RS05890 Genome accession   NZ_AP013072
Coordinates   1163549..1164895 (-) Length   448 a.a.
NCBI ID   WP_003036710.1    Uniprot ID   I0SCM6
Organism   Streptococcus anginosus subsp. whileyi MAS624     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1158549..1169895
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ANG_RS05870 (ANG_1184) rpsT 1159047..1159298 (+) 252 WP_020999623.1 30S ribosomal protein S20 -
  ANG_RS05875 (ANG_1185) - 1159362..1159871 (+) 510 WP_020999624.1 DNA topology modulation protein -
  ANG_RS05880 (ANG_1186) - 1159920..1161533 (-) 1614 WP_020999625.1 M20/M25/M40 family metallo-hydrolase -
  ANG_RS05885 (ANG_1187) - 1161710..1163158 (+) 1449 WP_003036764.1 alpha-amylase -
  ANG_RS05890 (ANG_1188) ciaH 1163549..1164895 (-) 1347 WP_003036710.1 sensor histidine kinase Regulator
  ANG_RS05895 (ANG_1189) ciaR 1164885..1165559 (-) 675 WP_003036714.1 response regulator transcription factor Regulator
  ANG_RS05900 (ANG_1190) - 1165834..1166289 (-) 456 WP_003036769.1 hypothetical protein -
  ANG_RS05905 (ANG_1191) - 1166626..1167369 (-) 744 WP_003036850.1 alpha/beta fold hydrolase -
  ANG_RS05910 (ANG_1192) - 1167829..1168077 (+) 249 WP_025271788.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
  ANG_RS05915 (ANG_1193) - 1168074..1168370 (+) 297 WP_003024343.1 type II toxin-antitoxin system RelE family toxin -
  ANG_RS05920 (ANG_1194) - 1168501..1169199 (-) 699 WP_003038287.1 hypothetical protein -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50890.68 Da        Isoelectric Point: 10.0709

>NTDB_id=65520 ANG_RS05890 WP_003036710.1 1163549..1164895(-) (ciaH) [Streptococcus anginosus subsp. whileyi MAS624]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARKVGLDQKSENGE
PKSGTADKELTDKPNVSANTEVILFDKNYKPIITSNNFLGFNKLSFNSKQLDHIRQIQVKSNYGREETYRMILFEVKLPN
LETNVKYAAVFINISQLEQTSQNHEQLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMEASESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKIFRF
DNRIHRVIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRNLFLKVSDNGSGISMADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTIAVKDNKPKGTIFEVKIAIRTDNKKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=65520 ANG_RS05890 WP_003036710.1 1163549..1164895(-) (ciaH) [Streptococcus anginosus subsp. whileyi MAS624]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTTAT
TTTCTCAGCTATGACCTTGATTATCATTCAAGTTATGCGCTCAAGCCTTTATACAACGGTAGATAACAATTTAAAAAGCT
TGAGTCAAGATTCGGCTTCTGTGATTAATTTAGCACTTGCTCGAAAAGTAGGGCTAGATCAAAAGTCAGAAAATGGAGAG
CCTAAAAGTGGAACAGCTGACAAAGAATTGACAGATAAACCAAATGTTAGTGCCAATACAGAAGTTATTTTATTTGATAA
GAATTATAAGCCGATTATTACAAGCAATAATTTCTTAGGATTCAATAAACTTTCCTTTAATAGCAAGCAATTAGACCACA
TTCGTCAGATTCAAGTAAAAAGCAATTATGGTCGAGAAGAAACCTATCGAATGATTTTATTTGAGGTAAAACTGCCTAAT
TTGGAGACCAATGTCAAATACGCAGCGGTTTTTATCAATATCAGTCAATTGGAACAAACTAGTCAAAATCATGAACAGTT
GATTGTGGTGGTGATGATTAGTTTCTGGGGAATTTCCTTGATTGCTAGTGTTTATCTTGCACGAGTCAGTGTTAAACCTC
TTTTAGAAAGCATTCAAAAGCAAAAAAGTTTTGTCGAAAACGCTAGTCATGAGTTGCGTACACCTCTAGCTGTGTTGCAA
AATCGTTTGGAGACTTTATTTAGAAAGCCAGAAGCTACTATTATGGAAGCCAGTGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGCAATATGAAAATGTTGACGACAAACTTACTCAATCTAGCACGGCGTGACGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACAACTTTCACCAACTATGAAATGGTTGCCGCAGAGAATGGGAAAATTTTCCGATTT
GACAATAGGATTCACCGCGTAATTAAAACGGATAAAACCTTACTGAAGCAATTGATGACTATCTTGTTTGATAATGCCCT
GAAATATACAGATGAAGATGGTGTGATTGAATTGACAATCTCTGCAAATGATCGAAATTTGTTTTTAAAGGTTTCAGATA
ATGGTTCGGGGATTAGTATGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGGGTTGATAAAGCACGGACTCGGCAG
ACAGGTGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCTCTTAAAGGAACCATTGCAGTGAAAGACAA
TAAGCCTAAAGGAACTATTTTTGAGGTGAAGATTGCGATTCGAACGGATAATAAAAAGAAAAAATAG

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SCM6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.982

100

0.71
  ciaH Streptococcus pneumoniae D39

70.982

100

0.71
  ciaH Streptococcus pneumoniae R6

70.982

100

0.71
  ciaH Streptococcus pneumoniae TIGR4

70.982

100

0.71
  ciaH Streptococcus mutans UA159

55.023

97.768

0.538

Multiple sequence alignment