Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   ANG_RS00665 Genome accession   NZ_AP013072
Coordinates   122369..123559 (-) Length   396 a.a.
NCBI ID   WP_003032033.1    Uniprot ID   I0S836
Organism   Streptococcus anginosus subsp. whileyi MAS624     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 117369..128559
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ANG_RS00640 (ANG_0108) - 117962..118461 (+) 500 Protein_104 DUF1307 domain-containing protein -
  ANG_RS00645 (ANG_0109) - 118485..118682 (-) 198 WP_003038262.1 DUF951 domain-containing protein -
  ANG_RS00650 (ANG_0110) dnaN 118682..119818 (-) 1137 WP_004225019.1 DNA polymerase III subunit beta -
  ANG_RS00655 (ANG_0111) dnaA 119975..121318 (-) 1344 WP_004225063.1 chromosomal replication initiator protein DnaA -
  ANG_RS00660 (ANG_0112) spo0J 121547..122314 (-) 768 WP_025271549.1 ParB/RepB/Spo0J family partition protein Regulator
  ANG_RS00665 (ANG_0113) htrA 122369..123559 (-) 1191 WP_003032033.1 S1C family serine protease Regulator
  ANG_RS00670 (ANG_0114) rlmH 123753..124232 (+) 480 WP_004225060.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  ANG_RS10760 (ANG_0115) - 124514..124663 (+) 150 WP_003038250.1 bacteriocin -
  ANG_RS00685 (ANG_0116) comD/comD2 124678..126000 (+) 1323 WP_003038254.1 GHKL domain-containing protein Regulator
  ANG_RS00690 (ANG_0117) comE/comE2 126000..126749 (+) 750 WP_003038257.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41651.61 Da        Isoelectric Point: 9.4264

>NTDB_id=65496 ANG_RS00665 WP_003032033.1 122369..123559(-) (htrA) [Streptococcus anginosus subsp. whileyi MAS624]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=65496 ANG_RS00665 WP_003032033.1 122369..123559(-) (htrA) [Streptococcus anginosus subsp. whileyi MAS624]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATCGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTGAAAGATGCTGTGGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGCGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGGGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACTCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGAATTAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGTAAATTGACGGTTGGTGAGACAGCTATTGCGATTGGAAG
TCCGCTCGGATCAAATTACGCTAACACTGTGACGCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTTTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATTAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATAGCTAGCAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGCTTAAAACTTCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S836

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.561

100

0.765
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.471

99.242

0.551

Multiple sequence alignment