Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   L6176_RS25690 Genome accession   NZ_CP091765
Coordinates   4873607..4874188 (+) Length   193 a.a.
NCBI ID   WP_001049158.1    Uniprot ID   -
Organism   Bacillus anthracis strain PNO2D1     
Function   degradation of ComK; degradation of DegU (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 4827277..4874188 4873607..4874188 within 0


Gene organization within MGE regions


Location: 4827277..4874188
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6176_RS25415 (L6176_25415) speG 4827277..4827792 (-) 516 WP_000076824.1 spermidine N1-acetyltransferase -
  L6176_RS25420 (L6176_25420) psiE 4827936..4828340 (-) 405 WP_000834704.1 phosphate-starvation-inducible protein PsiE -
  L6176_RS25425 (L6176_25425) - 4828390..4829352 (-) 963 WP_000635749.1 nuclease-related domain-containing protein -
  L6176_RS25430 (L6176_25430) - 4829788..4830753 (+) 966 WP_001036602.1 DUF4822 domain-containing protein -
  L6176_RS25435 (L6176_25435) - 4830978..4831730 (-) 753 WP_000590068.1 siderophore ABC transporter ATP-binding protein -
  L6176_RS25440 (L6176_25440) - 4831727..4832791 (-) 1065 WP_000631132.1 iron chelate uptake ABC transporter family permease subunit -
  L6176_RS25445 (L6176_25445) - 4832788..4833804 (-) 1017 WP_000042061.1 ABC transporter permease -
  L6176_RS25450 (L6176_25450) - 4833824..4834837 (-) 1014 WP_000753441.1 siderophore ABC transporter substrate-binding protein -
  L6176_RS25455 (L6176_25455) - 4835252..4835929 (-) 678 WP_001250248.1 response regulator transcription factor -
  L6176_RS25465 (L6176_25465) smpB 4836818..4837285 (-) 468 WP_001123905.1 SsrA-binding protein -
  L6176_RS25470 (L6176_25470) rnr 4837534..4839960 (-) 2427 WP_000391091.1 ribonuclease R -
  L6176_RS25475 (L6176_25475) estA 4840103..4840843 (-) 741 WP_000761977.1 carboxylesterase -
  L6176_RS25480 (L6176_25480) secG 4841005..4841238 (-) 234 WP_000557262.1 preprotein translocase subunit SecG -
  L6176_RS25485 (L6176_25485) - 4841333..4842025 (-) 693 WP_000078306.1 LrgB family protein -
  L6176_RS25490 (L6176_25490) - 4842022..4842390 (-) 369 WP_000673222.1 CidA/LrgA family holin-like protein -
  L6176_RS25495 (L6176_25495) - 4842666..4843616 (+) 951 WP_001125043.1 nucleoside hydrolase -
  L6176_RS27940 - 4843667..4843780 (-) 114 Protein_4997 hypothetical protein -
  L6176_RS25500 (L6176_25500) - 4844104..4844616 (-) 513 WP_000422852.1 hypothetical protein -
  L6176_RS25505 (L6176_25505) - 4844774..4845232 (-) 459 WP_000711928.1 hypothetical protein -
  L6176_RS25510 (L6176_25510) - 4845649..4846458 (-) 810 WP_000639551.1 NUMOD4 domain-containing protein -
  L6176_RS25515 (L6176_25515) - 4846633..4847262 (-) 630 WP_000142503.1 hypothetical protein -
  L6176_RS25520 (L6176_25520) - 4847450..4847800 (-) 351 WP_000817546.1 DUF2513 domain-containing protein -
  L6176_RS25525 (L6176_25525) - 4847945..4848421 (+) 477 WP_001003949.1 hypothetical protein -
  L6176_RS25530 (L6176_25530) - 4848487..4848663 (-) 177 WP_000664412.1 hypothetical protein -
  L6176_RS25535 (L6176_25535) - 4848660..4848872 (-) 213 WP_000660592.1 hypothetical protein -
  L6176_RS25540 (L6176_25540) - 4848878..4849123 (-) 246 WP_001008127.1 AlpA family transcriptional regulator -
  L6176_RS25545 (L6176_25545) - 4849120..4849365 (-) 246 WP_000823894.1 hypothetical protein -
  L6176_RS25550 (L6176_25550) - 4849518..4849721 (+) 204 WP_000502531.1 hypothetical protein -
  L6176_RS25555 (L6176_25555) - 4849740..4850477 (+) 738 WP_000811954.1 hypothetical protein -
  L6176_RS25560 (L6176_25560) - 4850888..4851079 (+) 192 WP_001001289.1 hypothetical protein -
  L6176_RS25565 (L6176_25565) - 4851176..4851763 (+) 588 WP_000900865.1 hypothetical protein -
  L6176_RS25570 (L6176_25570) - 4851756..4853327 (+) 1572 WP_003159006.1 terminase TerL endonuclease subunit -
  L6176_RS27945 - 4853478..4853870 (+) 393 WP_226992602.1 HNH endonuclease -
  L6176_RS25580 (L6176_25580) - 4854287..4855597 (+) 1311 WP_000522484.1 phage portal protein -
  L6176_RS25585 (L6176_25585) - 4855569..4856066 (+) 498 WP_003159003.1 HK97 family phage prohead protease -
  L6176_RS25590 (L6176_25590) - 4856126..4857166 (+) 1041 WP_003159030.1 phage major capsid protein -
  L6176_RS25595 (L6176_25595) - 4857253..4858233 (+) 981 WP_000168836.1 phage major capsid protein -
  L6176_RS25600 (L6176_25600) - 4858301..4859167 (-) 867 WP_000348695.1 hypothetical protein -
  L6176_RS25605 (L6176_25605) - 4859290..4860195 (-) 906 WP_000910235.1 tyrosine-type recombinase/integrase -
  L6176_RS25610 (L6176_25610) eno 4860339..4861634 (-) 1296 WP_000103949.1 phosphopyruvate hydratase -
  L6176_RS25615 (L6176_25615) gpmI 4861665..4863194 (-) 1530 WP_001231153.1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase -
  L6176_RS25620 (L6176_25620) tpiA 4863191..4863946 (-) 756 WP_001231039.1 triose-phosphate isomerase -
  L6176_RS25625 (L6176_25625) - 4863979..4865163 (-) 1185 WP_001036337.1 phosphoglycerate kinase -
  L6176_RS25630 (L6176_25630) gap 4865303..4866307 (-) 1005 WP_000161236.1 type I glyceraldehyde-3-phosphate dehydrogenase -
  L6176_RS25635 (L6176_25635) cggR 4866334..4867362 (-) 1029 WP_001258187.1 gapA transcriptional regulator CggR -
  L6176_RS25640 (L6176_25640) - 4867499..4867744 (-) 246 WP_000869728.1 glutaredoxin family protein -
  L6176_RS25645 (L6176_25645) rpoN 4867754..4869061 (-) 1308 WP_000647981.1 RNA polymerase factor sigma-54 -
  L6176_RS25655 (L6176_25655) - 4869601..4869807 (+) 207 WP_000216166.1 DUF1657 domain-containing protein -
  L6176_RS25660 (L6176_25660) - 4869901..4870386 (+) 486 WP_001228539.1 YhcN/YlaJ family sporulation lipoprotein -
  L6176_RS25665 (L6176_25665) spoVAC 4870417..4870893 (+) 477 WP_000095399.1 stage V sporulation protein AC -
  L6176_RS25670 (L6176_25670) spoVAD 4870894..4871910 (+) 1017 WP_000938967.1 stage V sporulation protein AD -
  L6176_RS25675 (L6176_25675) spoVAE 4871907..4872257 (+) 351 WP_000575919.1 stage V sporulation protein AE -
  L6176_RS25680 (L6176_25680) - 4872269..4872475 (+) 207 WP_000215915.1 DUF1657 domain-containing protein -
  L6176_RS25685 (L6176_25685) - 4872496..4873365 (+) 870 WP_000018934.1 DUF421 domain-containing protein -
  L6176_RS25690 (L6176_25690) clpP 4873607..4874188 (+) 582 WP_001049158.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP Regulator

Sequence

Protein


Download         Length: 193 a.a.        Molecular weight: 21391.62 Da        Isoelectric Point: 5.0423

>NTDB_id=653465 L6176_RS25690 WP_001049158.1 4873607..4874188(+) (clpP) [Bacillus anthracis strain PNO2D1]
MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSIVSQLLFLESQDPEKDIHIYINSPGGSITAGMAIYDT
MQFIKPQVSTICIGMAASMGAFLLAAGEKGKRYALPNSEAMIHQPLGGAQGQATEIEIAAKRILFLREKLNQILADRTGQ
PLEVLQRDTDRDNFMTAEKALEYGLIDKIFTNR

Nucleotide


Download         Length: 582 bp        

>NTDB_id=653465 L6176_RS25690 WP_001049158.1 4873607..4874188(+) (clpP) [Bacillus anthracis strain PNO2D1]
ATGAATTTAATTCCTACAGTAATTGAACAAACAAATCGTGGAGAACGCGCTTACGATATTTACTCTCGACTATTAAAAGA
CCGTATCATTATGCTTGGTAGTGCAATTGATGACAACGTAGCTAACTCAATCGTTTCCCAGCTTTTATTCTTGGAATCTC
AAGATCCTGAAAAAGATATTCATATCTACATCAACAGCCCTGGTGGTTCTATCACAGCAGGTATGGCAATTTACGATACA
ATGCAGTTTATTAAACCGCAAGTATCAACAATCTGTATCGGTATGGCTGCATCTATGGGTGCATTCTTACTTGCAGCAGG
TGAAAAAGGAAAACGTTATGCACTTCCAAACAGTGAAGCAATGATTCACCAACCACTTGGTGGGGCACAAGGTCAAGCGA
CTGAAATCGAAATCGCTGCTAAACGTATCCTATTCTTACGTGAAAAACTAAACCAAATTCTTGCTGACCGCACAGGTCAA
CCACTTGAAGTACTACAACGCGACACAGACCGCGACAACTTCATGACAGCAGAAAAAGCTTTAGAATACGGTTTAATCGA
TAAGATCTTTACAAATCGTTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(13-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Bacillus subtilis subsp. subtilis str. 168

89.583

99.482

0.891
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

67.021

97.409

0.653
  clpP Streptococcus thermophilus LMG 18311

60.417

99.482

0.601
  clpP Streptococcus thermophilus LMD-9

60.417

99.482

0.601
  clpP Lactococcus lactis subsp. cremoris KW2

58.854

99.482

0.585
  clpP Streptococcus pneumoniae D39

57.292

99.482

0.57
  clpP Streptococcus pneumoniae Rx1

57.292

99.482

0.57
  clpP Streptococcus pneumoniae R6

57.292

99.482

0.57
  clpP Streptococcus pneumoniae TIGR4

57.292

99.482

0.57
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

56.771

99.482

0.565
  clpP Streptococcus pyogenes JRS4

55.729

99.482

0.554
  clpP Streptococcus pyogenes MGAS315

55.729

99.482

0.554
  clpP Streptococcus mutans UA159

55.44

100

0.554