Detailed information NTG0651059

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: L3X15_RS04855
• Genome accession: NZ_CP091423
• Coordinates: 987728..988399 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain LSM29
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 982728..993399

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L3X15_RS04825 (L3X15_04825)	pstC	982911..983828 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
L3X15_RS04830 (L3X15_04830)	pstA	983818..984705 (+)	888	WP_024402495.1	phosphate ABC transporter permease PstA	-
L3X15_RS04835 (L3X15_04835)	pstB	984730..985533 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
L3X15_RS04840 (L3X15_04840)	pstB	985545..986303 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
L3X15_RS04845 (L3X15_04845)	phoU	986332..986988 (+)	657	WP_024402496.1	phosphate signaling complex protein PhoU	-
L3X15_RS04850 (L3X15_04850)	-	987154..987534 (+)	381	WP_023369940.1	hypothetical protein	-
L3X15_RS04855 (L3X15_04855)	ciaR	987728..988399 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
L3X15_RS04860 (L3X15_04860)	ciaH	988392..989771 (+)	1380	WP_237374735.1	sensor histidine kinase	Regulator
L3X15_RS04865 (L3X15_04865)	-	990102..991331 (+)	1230	WP_012027071.1	transglutaminase domain-containing protein	-
L3X15_RS04870 (L3X15_04870)	tnpA	991745..992209 (+)	465	WP_237374737.1	IS200/IS605-like element ISSsu4 family transposase	-
L3X15_RS04875 (L3X15_04875)	rpsT	992351..992599 (-)	249	WP_012027069.1	30S ribosomal protein S20	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=651059 L3X15_RS04855 WP_009909965.1 987728..988399(+) (ciaR) [Streptococcus suis strain LSM29]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=651059 L3X15_RS04855 WP_009909965.1 987728..988399(+) (ciaR) [Streptococcus suis strain LSM29]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAGTTACGTGAAAAGGGGGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363