NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	L1A14_RS04615	Genome accession	NZ_CP090883
Coordinates	896192..896842 (+)	Length	216 a.a.
NCBI ID	WP_000387335.1	Uniprot ID	A0A0B7MF65
Organism	Streptococcus pneumoniae strain LE4448
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 891192..901842

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L1A14_RS04585 (L1A14_04585)	-	891676..891891 (+)	216	WP_001232082.1	YozE family protein	-
L1A14_RS04590 (L1A14_04590)	-	891977..892945 (+)	969	WP_000658183.1	PhoH family protein	-
L1A14_RS04595 (L1A14_04595)	-	893138..893638 (+)	501	WP_000566982.1	GNAT family N-acetyltransferase	-
L1A14_RS04600 (L1A14_04600)	-	893641..893966 (+)	326	Protein_902	TfoX/Sxy family protein	-
L1A14_RS04605 (L1A14_04605)	ald	894267..895378 (-)	1112	Protein_903	alanine dehydrogenase	-
L1A14_RS04610 (L1A14_04610)	-	895555..896124 (+)	570	WP_000443774.1	GNAT family N-acetyltransferase	-
L1A14_RS04615 (L1A14_04615)	comEA/celA/cilE	896192..896842 (+)	651	WP_000387335.1	helix-hairpin-helix domain-containing protein	Machinery gene
L1A14_RS04620 (L1A14_04620)	comEC/celB	896826..899066 (+)	2241	WP_000942414.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
L1A14_RS04625 (L1A14_04625)	-	899245..899433 (+)	189	WP_001809102.1	hypothetical protein	-
L1A14_RS04630 (L1A14_04630)	-	899465..900052 (+)	588	WP_000933542.1	ABC transporter ATP-binding protein	-
L1A14_RS04635 (L1A14_04635)	-	900056..901231 (+)	1176	WP_000655957.1	ABC transporter permease	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23229.61 Da Isoelectric Point: 5.2344

                                >NTDB_id=645679 L1A14_RS04615 WP_000387335.1 896192..896842(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain LE4448]

MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG

AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTNGEEAVSQQTGLGTASSISKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=645679 L1A14_RS04615 WP_000387335.1 896192..896842(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain LE4448]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT

TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT

TGGTATCCGAAAAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT

GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC

AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAATGGAG

AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCT

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG

CAAGTTCAAATCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACTATAGAAAAGTTAAAAGACTATGTTA

CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0B7MF65

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae D39	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae R6	99.074	100	0.991
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.278	100	0.903
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.053	87.963	0.361

Detailed information NTG0645679