Detailed information NTG0622658

Bioinformatically predicted

Overview

• Name: clpP
• Type: Regulator
• Locus tag: M5S63_RS18280
• Genome accession: NZ_CP103521
• Coordinates: 3756812..3757435 (-)
• Length: 207 a.a.
• NCBI ID: WP_000122253.1
• Uniprot ID: A0A370V1H3
• Organism: Escherichia coli strain 2779 - blood draw same patient as MB9267
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 3751812..3762435

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M5S63_RS18265 (M5S63_18265)	hupB	3752389..3752661 (-)	273	WP_001043542.1	nucleoid-associated protein HU-beta	-
M5S63_RS18270 (M5S63_18270)	lon	3752870..3755224 (-)	2355	WP_001295325.1	endopeptidase La	-
M5S63_RS18275 (M5S63_18275)	clpX	3755412..3756686 (-)	1275	WP_000130305.1	ATP-dependent protease ATP-binding subunit ClpX	Regulator
M5S63_RS18280 (M5S63_18280)	clpP	3756812..3757435 (-)	624	WP_000122253.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	Regulator
M5S63_RS18285 (M5S63_18285)	tig	3757681..3758979 (-)	1299	WP_001198386.1	trigger factor	-
M5S63_RS18290 (M5S63_18290)	bolA	3759323..3759640 (-)	318	WP_000973448.1	transcriptional regulator BolA	-
M5S63_RS18295 (M5S63_18295)	yajG	3759945..3760523 (+)	579	WP_000473501.1	lipoprotein	-
M5S63_RS18300 (M5S63_18300)	ampG	3760567..3762042 (+)	1476	WP_000098423.1	muropeptide MFS transporter AmpG	-

Sequence

Protein

• Length: 207 a.a.
• Molecular weight: 23186.65 Da
• Isoelectric Point: 5.6032

>NTDB_id=622658 M5S63_RS18280 WP_000122253.1 3756812..3757435(-) (clpP) [Escherichia coli strain 2779 - blood draw same patient as MB9267]
MSYSGERDNFAPHMALVPMVIEQTSRGERSFDIYSRLLKERVIFLTGQVEDHMANLIVAQMLFLEAENPEKDIYLYINSP
GGVITAGMSIYDTMQFIKPDVSTICMGQAASMGAFLLTAGAKGKRFCLPNSRVMIHQPLGGYQGQATDIEIHAREILKVK
GRMNELMALHTGQSLEQIERDTERDRFLSAPEAVEYGLVDSILTHRN

Nucleotide

• Length: 624 bp

>NTDB_id=622658 M5S63_RS18280 WP_000122253.1 3756812..3757435(-) (clpP) [Escherichia coli strain 2779 - blood draw same patient as MB9267]
ATGTCATACAGCGGCGAACGAGATAACTTTGCACCCCATATGGCGCTGGTGCCGATGGTCATTGAACAGACCTCACGTGG
TGAGCGCTCTTTTGATATCTATTCTCGTCTACTTAAGGAACGCGTCATTTTTCTGACTGGCCAGGTTGAAGACCACATGG
CTAACCTGATTGTGGCGCAGATGCTGTTCTTGGAAGCAGAAAACCCAGAAAAAGATATCTATCTGTACATTAACTCCCCA
GGCGGGGTGATCACTGCCGGGATGTCTATCTATGACACCATGCAGTTTATCAAGCCTGATGTCAGCACCATCTGTATGGG
CCAGGCGGCTTCGATGGGCGCTTTCTTGCTGACTGCAGGGGCAAAAGGTAAACGTTTCTGCCTGCCGAATTCGCGCGTGA
TGATTCACCAGCCGTTGGGCGGCTACCAGGGCCAGGCGACCGATATCGAAATTCATGCCCGTGAAATTCTGAAAGTTAAA
GGGCGCATGAATGAACTTATGGCGCTTCATACGGGTCAATCATTAGAACAGATTGAACGTGATACCGAGCGCGATCGCTT
CCTTTCCGCCCCTGAAGCGGTGGAATACGGTCTGGTCGATTCGATTCTGACCCATCGTAATTGA

Domains

Predicted by InterProScan.

• Clp protease (CLP_protease) (26-205)

3D structure

• AlphaFold DB: A0A370V1H3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpP	Bacillus subtilis subsp. subtilis str. 168	69.792	92.754	0.647
clpP	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	68.617	90.821	0.623
clpP	Lactococcus lactis subsp. cremoris KW2	56.701	93.72	0.531
clpP	Streptococcus pneumoniae R6	55.155	93.72	0.517
clpP	Streptococcus pneumoniae TIGR4	55.155	93.72	0.517
clpP	Lactococcus lactis subsp. lactis strain DGCC12653	55.155	93.72	0.517
clpP	Streptococcus pneumoniae Rx1	55.155	93.72	0.517
clpP	Streptococcus pneumoniae D39	55.155	93.72	0.517
clpP	Streptococcus thermophilus LMD-9	54.922	93.237	0.512
clpP	Streptococcus thermophilus LMG 18311	54.922	93.237	0.512
clpP	Streptococcus pyogenes JRS4	55.263	91.787	0.507
clpP	Streptococcus pyogenes MGAS315	55.263	91.787	0.507
clpP	Streptococcus mutans UA159	53.886	93.237	0.502