Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SCI_RS05135 Genome accession   NC_022238
Coordinates   1034362..1035036 (-) Length   224 a.a.
NCBI ID   WP_003068917.1    Uniprot ID   F9P6F2
Organism   Streptococcus constellatus subsp. pharyngis C1050     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1029362..1040036
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCI_RS05125 (SCI_1010) - 1031146..1032594 (+) 1449 WP_006267911.1 alpha-amylase -
  SCI_RS05130 (SCI_1011) ciaH 1033026..1034372 (-) 1347 WP_006267810.1 cell wall metabolism sensor histidine kinase WalK Regulator
  SCI_RS05135 (SCI_1012) ciaR 1034362..1035036 (-) 675 WP_003068917.1 response regulator transcription factor Regulator
  SCI_RS05140 (SCI_1013) - 1035300..1035743 (-) 444 WP_020997812.1 hypothetical protein -
  SCI_RS05145 (SCI_1014) - 1036071..1036829 (-) 759 WP_020997813.1 alpha/beta fold hydrolase -
  SCI_RS05155 (SCI_1016) rplS 1037074..1037421 (-) 348 WP_003024326.1 50S ribosomal protein L19 -
  SCI_RS05160 (SCI_1017) - 1037571..1038530 (-) 960 WP_020997820.1 ROK family glucokinase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25300.97 Da        Isoelectric Point: 4.2703

>NTDB_id=61597 SCI_RS05135 WP_003068917.1 1034362..1035036(-) (ciaR) [Streptococcus constellatus subsp. pharyngis C1050]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKGLREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTINLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=61597 SCI_RS05135 WP_003068917.1 1034362..1035036(-) (ciaR) [Streptococcus constellatus subsp. pharyngis C1050]
ATGATTAAGATTCTATTAGTAGAAGATGACCTTGGTTTATCTAACTCAGTATTTGATTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAGGAAGGATTGTACGAAGCCGAAAGTGGTGTGTACGATCTTATCTTACTTGATTTGATGT
TACCGGAAAAAGACGGTTTTCAAGTATTGAAGGGATTACGTGAAAAAGGTGTTACAACACCGGTATTGATTATGACAGCT
AAAGAGAGTTTGAATGATAAAGGACATGGCTTTGAGCTGGGAGCCGACGATTATTTGACCAAACCATTTTATTTGGAAGA
GTTAAAAATGCGGATTCAAGCTCTTTTGAAACGATCGGGCAAGTTTAATGAAAATACTCTTTCTTATGGCGATGTAACCA
TTAATTTGTCAACGAACACGACACTTGTAGATGGAAATGAAGTAGAGTTACTCGGAAAAGAATTTGATTTATTAGTATAT
TTCTTGCAGAATCAAAATGTTATTCTACCGAAGACGCAGATTTTCGATCGCTTATGGGGGTTTGATAGTGATACAACCAT
TTCAGTTGTAGAAGTTTATGTCTCAAAAATTCGGAAAAAATTGAAAGGGACGACCTTTGCGAATAATCTTCAAACACTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB F9P6F2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.071

100

0.911
  ciaR Streptococcus pneumoniae D39

91.071

100

0.911
  ciaR Streptococcus pneumoniae R6

91.071

100

0.911
  ciaR Streptococcus pneumoniae TIGR4

91.071

100

0.911
  ciaR Streptococcus mutans UA159

89.238

99.554

0.888
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362

Multiple sequence alignment