NTDB

Overview

Name	micA	Type	Regulator
Locus tag	K6969_RS03745	Genome accession	NZ_CP082205
Coordinates	741829..742533 (+)	Length	234 a.a.
NCBI ID	WP_004298854.1	Uniprot ID	A0A0K2E6P6
Organism	Streptococcus suis strain AKJ18
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 736829..747533

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6969_RS03715 (K6969_03655)	-	737467..738261 (-)	795	WP_004298841.1	acyltransferase family protein	-
K6969_RS03720 (K6969_03660)	-	738233..738514 (-)	282	WP_105096634.1	acyltransferase family protein	-
K6969_RS03725 (K6969_03665)	-	738637..739296 (-)	660	WP_029174360.1	amino acid ABC transporter permease	-
K6969_RS03730 (K6969_03670)	-	739311..740009 (-)	699	WP_004298848.1	amino acid ABC transporter permease	-
K6969_RS03735 (K6969_03675)	-	740024..740863 (-)	840	WP_029174361.1	transporter substrate-binding domain-containing protein	-
K6969_RS03740 (K6969_03680)	-	740874..741635 (-)	762	WP_171942725.1	amino acid ABC transporter ATP-binding protein	-
K6969_RS03745 (K6969_03685)	micA	741829..742533 (+)	705	WP_004298854.1	response regulator YycF	Regulator
K6969_RS03750 (K6969_03690)	micB	742526..743875 (+)	1350	WP_024379730.1	cell wall metabolism sensor histidine kinase VicK	Regulator
K6969_RS03755 (K6969_03695)	vicX	743882..744685 (+)	804	WP_002935843.1	MBL fold metallo-hydrolase	Regulator
K6969_RS03760 (K6969_03700)	vga(F)	745047..746432 (+)	1386	WP_253911801.1	ABC-F type ribosomal protection protein Vga(F)	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26781.77 Da Isoelectric Point: 4.8957

                                >NTDB_id=600042 K6969_RS03745 WP_004298854.1 741829..742533(+) (micA) [Streptococcus suis strain AKJ18]

MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALEVFEAEFPDIVILDLMLPELDGLEVARTIRKTSNVPILMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRSELAETQTNIESTGTPELVIGDLVILPDAFVAKKHGKELELT

HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGND

Nucleotide

Download Length: 705 bp

                                >NTDB_id=600042 K6969_RS03745 WP_004298854.1 741829..742533(+) (micA) [Streptococcus suis strain AKJ18]

ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCAGATATTATTAAGTTTAATATGACGCGTGAGGGATATGA

AGTTGTGACAGCTTTCGATGGACGTGAAGCCTTGGAAGTATTTGAGGCTGAGTTTCCTGACATTGTCATTTTGGACTTGA

TGCTGCCAGAATTGGACGGACTAGAGGTTGCTCGAACGATTCGTAAGACCAGCAATGTTCCAATCTTGATGTTATCTGCT

AAAGATAGCGAATTTGATAAGGTTATCGGGCTTGAAATCGGGGCGGATGATTATGTGACCAAGCCCTTCTCTAATCGCGA

ATTGCAGGCGCGTGTTAAGGCTCTTCTTCGTCGTAGTGAATTGGCAGAGACGCAGACAAATATTGAGTCAACAGGAACTC

CAGAGTTGGTGATTGGCGATTTGGTCATTCTGCCTGATGCGTTTGTCGCTAAGAAGCATGGCAAAGAGCTGGAGCTGACC

CATCGTGAGTTTGAATTGCTCCACCATCTGGCCAAACACTTAGGTCAGGTTATGACTCGAGAACATCTATTGGAAACAGT

TTGGGGTTATGATTACTTTGGTGATGTCCGCACGGTGGATGTAACGATTCGTCGTCTGCGTGAGAAAATTGAAGATACAC

CAAGCCGACCAGAATACATTCTTACTCGTCGCGGAGTGGGATATTTTATAAAAGGAAATGATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0K2E6P6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	81.974	99.573	0.816
vicR	Streptococcus mutans UA159	80.426	100	0.808
covR	Lactococcus lactis subsp. lactis strain DGCC12653	44.783	98.291	0.44
covR	Streptococcus salivarius strain HSISS4	43.723	98.718	0.432
scnR	Streptococcus mutans UA159	38.095	98.718	0.376

Detailed information NTG0600042