Detailed information NTG0599987

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: K6974_RS04730
• Genome accession: NZ_CP082204
• Coordinates: 936014..936685 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain FJSM5
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 931014..941685

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6974_RS04700 (K6974_04645)	pstC	931093..932010 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
K6974_RS04705 (K6974_04650)	pstA	932000..932887 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
K6974_RS04710 (K6974_04655)	pstB	932912..933715 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
K6974_RS04715 (K6974_04660)	pstB	933727..934485 (+)	759	WP_172046551.1	phosphate ABC transporter ATP-binding protein PstB	-
K6974_RS04720 (K6974_04665)	phoU	934514..935170 (+)	657	WP_024399033.1	phosphate signaling complex protein PhoU	-
K6974_RS04725	-	935320..935868 (+)	549	WP_029997972.1	hypothetical protein	-
K6974_RS04730 (K6974_04675)	ciaR	936014..936685 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
K6974_RS04735 (K6974_04680)	ciaH	936678..938057 (+)	1380	WP_029187994.1	cell wall metabolism sensor histidine kinase WalK	Regulator
K6974_RS04740 (K6974_04685)	-	938158..939387 (+)	1230	WP_222336752.1	transglutaminase domain-containing protein	-
K6974_RS04745 (K6974_04690)	rpsT	939640..939888 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
K6974_RS04750 (K6974_04695)	coaA	939947..940867 (-)	921	WP_002935283.1	type I pantothenate kinase	-
K6974_RS04755 (K6974_04700)	-	940976..941566 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=599987 K6974_RS04730 WP_014637852.1 936014..936685(+) (ciaR) [Streptococcus suis strain FJSM5]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=599987 K6974_RS04730 WP_014637852.1 936014..936685(+) (ciaR) [Streptococcus suis strain FJSM5]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TACCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGTCATGGTTTTGAATTGGGCGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACGACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368