Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   K6972_RS07220 Genome accession   NZ_CP082203
Coordinates   1457907..1458497 (-) Length   196 a.a.
NCBI ID   WP_002937303.1    Uniprot ID   A0A0K2E545
Organism   Streptococcus suis strain NJ3     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1420919..1477639 1457907..1458497 within 0


Gene organization within MGE regions


Location: 1420919..1477639
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6972_RS07015 (K6972_07015) - 1421293..1422192 (+) 900 WP_024407083.1 cation transporter -
  K6972_RS07020 (K6972_07020) - 1422209..1422562 (-) 354 WP_002935368.1 arsenate reductase family protein -
  K6972_RS07025 (K6972_07025) - 1422546..1423052 (-) 507 WP_222812413.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
  K6972_RS07030 (K6972_07030) - 1423055..1424236 (-) 1182 WP_014638089.1 phosphoglycerate dehydrogenase -
  K6972_RS07035 (K6972_07035) - 1424290..1424847 (-) 558 WP_105119664.1 GNAT family N-acetyltransferase -
  K6972_RS07040 (K6972_07040) serC 1424847..1425938 (-) 1092 WP_105141375.1 3-phosphoserine/phosphohydroxythreonine transaminase -
  K6972_RS07045 (K6972_07045) rsmI 1426361..1427224 (-) 864 WP_029171338.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
  K6972_RS07050 (K6972_07050) yabA 1427226..1427543 (-) 318 WP_002935361.1 DNA replication initiation control protein YabA -
  K6972_RS07055 (K6972_07055) - 1427563..1428447 (-) 885 WP_222812414.1 DNA polymerase III subunit delta' -
  K6972_RS07060 (K6972_07060) tmk 1428444..1429082 (-) 639 WP_024413531.1 dTMP kinase -
  K6972_RS07065 (K6972_07065) - 1429609..1430475 (+) 867 WP_002935357.1 YitT family protein -
  K6972_RS07070 (K6972_07070) - 1430516..1431784 (-) 1269 WP_222812415.1 toxic anion resistance protein -
  K6972_RS07075 (K6972_07075) - 1431790..1432617 (-) 828 WP_222812416.1 hypothetical protein -
  K6972_RS07080 (K6972_07080) - 1432711..1433367 (-) 657 WP_002935353.1 CBS domain-containing protein -
  K6972_RS07085 (K6972_07085) - 1433451..1434206 (-) 756 WP_024407091.1 epoxyqueuosine reductase QueH -
  K6972_RS07090 (K6972_07090) - 1434653..1435363 (-) 711 WP_002937288.1 ABC transporter ATP-binding protein -
  K6972_RS07095 (K6972_07095) - 1435363..1436127 (-) 765 WP_002937291.1 ABC transporter ATP-binding protein -
  K6972_RS07100 (K6972_07100) - 1436127..1437074 (-) 948 WP_002937293.1 branched-chain amino acid ABC transporter permease -
  K6972_RS07105 (K6972_07105) - 1437077..1437964 (-) 888 WP_012027482.1 branched-chain amino acid ABC transporter permease -
  K6972_RS07110 (K6972_07110) - 1438165..1439334 (-) 1170 WP_105134813.1 ABC transporter substrate-binding protein -
  K6972_RS07115 (K6972_07115) - 1439766..1440080 (+) 315 WP_000420682.1 YdcP family protein -
  K6972_RS07120 (K6972_07120) - 1440096..1440482 (+) 387 WP_000985015.1 YdcP family protein -
  K6972_RS07125 (K6972_07125) - 1440511..1441896 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  K6972_RS07130 (K6972_07130) - 1441899..1442051 (+) 153 WP_000879507.1 hypothetical protein -
  K6972_RS07135 (K6972_07135) mobT 1442074..1443279 (+) 1206 WP_000398284.1 MobT family relaxase -
  K6972_RS07140 (K6972_07140) - 1443322..1443543 (+) 222 WP_001009056.1 hypothetical protein -
  K6972_RS07145 (K6972_07145) - 1443660..1444157 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  K6972_RS07150 (K6972_07150) - 1444246..1444638 (+) 393 WP_000723888.1 conjugal transfer protein -
  K6972_RS07155 (K6972_07155) - 1444622..1447069 (+) 2448 WP_000331160.1 ATP-binding protein -
  K6972_RS07160 (K6972_07160) - 1447072..1449249 (+) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  K6972_RS07165 (K6972_07165) - 1449246..1450247 (+) 1002 WP_000769868.1 lysozyme family protein -
  K6972_RS07170 (K6972_07170) - 1450244..1451179 (+) 936 WP_001224320.1 conjugal transfer protein -
  K6972_RS10755 - 1451493..1451540 (+) 48 Protein_1379 hypothetical protein -
  K6972_RS07180 (K6972_07180) tet(M) 1451556..1453475 (+) 1920 WP_043029018.1 tetracycline resistance ribosomal protection protein Tet(M) -
  K6972_RS07185 (K6972_07185) - 1453594..1453761 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  K6972_RS07190 (K6972_07190) - 1453821..1454174 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  K6972_RS07195 (K6972_07195) - 1454679..1455101 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  K6972_RS07200 (K6972_07200) - 1455098..1455328 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  K6972_RS10620 - 1455554..1455805 (-) 252 WP_001845478.1 hypothetical protein -
  K6972_RS07205 (K6972_07205) - 1455789..1455992 (+) 204 WP_000814511.1 excisionase -
  K6972_RS07210 (K6972_07210) - 1456074..1457291 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  K6972_RS07215 (K6972_07215) - 1457508..1457780 (-) 273 WP_024414725.1 YlbG family protein -
  K6972_RS07220 (K6972_07220) clpP 1457907..1458497 (-) 591 WP_002937303.1 ATP-dependent Clp protease proteolytic subunit Regulator
  K6972_RS07225 (K6972_07225) upp 1458620..1459249 (-) 630 WP_012027487.1 uracil phosphoribosyltransferase -
  K6972_RS07230 (K6972_07230) - 1459329..1460945 (-) 1617 WP_114866671.1 alpha-glucosidase -
  K6972_RS07235 (K6972_07235) gtfA 1461017..1462465 (-) 1449 WP_114866672.1 sucrose phosphorylase -
  K6972_RS07240 (K6972_07240) - 1462535..1463365 (-) 831 WP_222812417.1 carbohydrate ABC transporter permease -
  K6972_RS07245 (K6972_07245) - 1463376..1464248 (-) 873 WP_014636472.1 carbohydrate ABC transporter permease -
  K6972_RS07250 (K6972_07250) - 1464383..1465618 (-) 1236 WP_222759195.1 extracellular solute-binding protein -
  K6972_RS07255 (K6972_07255) - 1465631..1467805 (-) 2175 WP_222812418.1 alpha-galactosidase -
  K6972_RS07260 (K6972_07260) - 1467911..1468750 (+) 840 WP_002937318.1 AraC family transcriptional regulator -
  K6972_RS07265 (K6972_07265) - 1468782..1469942 (-) 1161 WP_222812419.1 MalY/PatB family protein -
  K6972_RS07270 (K6972_07270) - 1469946..1471037 (-) 1092 WP_024408682.1 cystathionine gamma-synthase -
  K6972_RS07275 (K6972_07275) - 1471283..1471498 (+) 216 WP_261984169.1 hypothetical protein -
  K6972_RS07280 (K6972_07280) - 1471515..1471769 (+) 255 WP_222812421.1 hypothetical protein -
  K6972_RS07285 (K6972_07285) - 1471779..1472030 (+) 252 WP_222812422.1 hypothetical protein -
  K6972_RS07290 (K6972_07290) - 1472484..1473233 (+) 750 WP_222812423.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  K6972_RS07295 (K6972_07295) - 1473223..1473495 (+) 273 WP_222812424.1 GIY-YIG nuclease family protein -
  K6972_RS07300 (K6972_07300) - 1473511..1474122 (-) 612 WP_222759198.1 FMN-dependent NADH-azoreductase -
  K6972_RS07305 (K6972_07305) - 1474241..1474651 (-) 411 WP_222759199.1 GNAT family N-acetyltransferase -
  K6972_RS07310 (K6972_07310) - 1474762..1475361 (-) 600 WP_222759200.1 DUF1648 domain-containing protein -
  K6972_RS07315 (K6972_07315) - 1475348..1475626 (-) 279 WP_105112794.1 autorepressor SdpR family transcription factor -
  K6972_RS07320 (K6972_07320) - 1475770..1477350 (-) 1581 WP_109371691.1 DEAD/DEAH box helicase -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21494.74 Da        Isoelectric Point: 5.7110

>NTDB_id=599938 K6972_RS07220 WP_002937303.1 1457907..1458497(-) (clpP) [Streptococcus suis strain NJ3]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDPTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGTAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNKLEKILADNSGK
TVKQIHKDAERDYWMSAEETLAYGFIDQIMDNTKVK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=599938 K6972_RS07220 WP_002937303.1 1457907..1458497(-) (clpP) [Streptococcus suis strain NJ3]
ATGATTCCAGTAGTTATTGAACAAACTAGCCGTGGTGAGCGCTCGTATGATATTTATTCCCGTTTGCTCAAGGATCGCAT
TATCATGTTGACAGGACCAGTTGAGGACAACATGGCAAACTCTATCATTGCACAATTGCTTTTCCTTGATGCCCAAGATC
CTACAAAGGATATTTACCTCTATGTTAATACGCCAGGAGGATCGGTGTCAGCAGGTCTAGCCATTGTAGACACGATGAAT
TTCATTAAAGCTGATGTTCAAACCATCGTTATGGGAACAGCTGCGAGCATGGGAACCATCATTGCATCAAGCGGTGCCAA
GGGCAAACGTTTCATGTTGCCAAATGCAGAGTACATGATTCACCAACCGATGGGTGGAACAGGTGGTGGCACTCAGCAAA
CAGACATGGCTATTGCAGCAGAACATCTATTAAAAACACGTAATAAGCTAGAAAAAATATTGGCAGATAATTCAGGTAAG
ACAGTCAAGCAAATCCATAAGGATGCAGAACGTGATTACTGGATGTCAGCAGAAGAAACCTTGGCTTACGGATTTATTGA
CCAGATTATGGACAATACAAAAGTCAAATAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0K2E545

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes JRS4

92.347

100

0.923
  clpP Streptococcus pyogenes MGAS315

92.347

100

0.923
  clpP Streptococcus mutans UA159

90.306

100

0.903
  clpP Streptococcus pneumoniae R6

88.776

100

0.888
  clpP Streptococcus pneumoniae Rx1

88.776

100

0.888
  clpP Streptococcus pneumoniae D39

88.776

100

0.888
  clpP Streptococcus pneumoniae TIGR4

88.776

100

0.888
  clpP Streptococcus thermophilus LMG 18311

88.776

100

0.888
  clpP Streptococcus thermophilus LMD-9

88.776

100

0.888
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

84.184

100

0.842
  clpP Lactococcus lactis subsp. cremoris KW2

83.673

100

0.837
  clpP Bacillus subtilis subsp. subtilis str. 168

58.163

100

0.582
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.549

98.469

0.577