Detailed information NTG0599930

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: K6972_RS04495
• Genome accession: NZ_CP082203
• Coordinates: 895891..896562 (+)
• Length: 223 a.a.
• NCBI ID: WP_009909965.1
• Uniprot ID: A0A075SH40
• Organism: Streptococcus suis strain NJ3
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 890891..901562

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6972_RS04465 (K6972_04465)	pstC	891047..891964 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
K6972_RS04470 (K6972_04470)	pstA	891954..892841 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
K6972_RS04475 (K6972_04475)	pstB	892866..893669 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
K6972_RS04480 (K6972_04480)	pstB	893681..894439 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
K6972_RS04485 (K6972_04485)	phoU	894468..895124 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
K6972_RS04490 (K6972_04490)	-	895290..895697 (+)	408	WP_222812928.1	hypothetical protein	-
K6972_RS04495 (K6972_04495)	ciaR	895891..896562 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
K6972_RS04500 (K6972_04500)	ciaH	896555..897934 (+)	1380	WP_222812930.1	cell wall metabolism sensor histidine kinase WalK	Regulator
K6972_RS04505 (K6972_04505)	-	898035..899264 (+)	1230	WP_222812931.1	transglutaminase domain-containing protein	-
K6972_RS04510 (K6972_04510)	rpsT	899528..899776 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
K6972_RS04515 (K6972_04515)	coaA	899835..900755 (-)	921	WP_002935283.1	type I pantothenate kinase	-
K6972_RS04520 (K6972_04520)	-	900864..901454 (+)	591	WP_222812932.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25290.00 Da
• Isoelectric Point: 4.2183

>NTDB_id=599930 K6972_RS04495 WP_009909965.1 895891..896562(+) (ciaR) [Streptococcus suis strain NJ3]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=599930 K6972_RS04495 WP_009909965.1 895891..896562(+) (ciaR) [Streptococcus suis strain NJ3]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG
TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT
TTCTTGCAAAACCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTTGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A075SH40

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363