Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   K6976_RS07545 Genome accession   NZ_CP082202
Coordinates   1539754..1540344 (-) Length   196 a.a.
NCBI ID   WP_002937303.1    Uniprot ID   A0A0K2E545
Organism   Streptococcus suis strain SS389     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1521613..1539138 1539754..1540344 flank 616


Gene organization within MGE regions


Location: 1521613..1540344
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  K6976_RS07440 (K6976_07440) - 1521613..1521927 (+) 315 WP_000420682.1 YdcP family protein -
  K6976_RS07445 (K6976_07445) - 1521943..1522329 (+) 387 WP_000985015.1 YdcP family protein -
  K6976_RS07450 (K6976_07450) - 1522358..1523743 (+) 1386 WP_000813488.1 FtsK/SpoIIIE domain-containing protein -
  K6976_RS07455 (K6976_07455) - 1523746..1523898 (+) 153 WP_000879507.1 hypothetical protein -
  K6976_RS07460 (K6976_07460) mobT 1523921..1525126 (+) 1206 Protein_1433 MobT family relaxase -
  K6976_RS07465 (K6976_07465) - 1525169..1525390 (+) 222 WP_001009056.1 hypothetical protein -
  K6976_RS07470 (K6976_07470) - 1525507..1526004 (+) 498 WP_000342539.1 antirestriction protein ArdA -
  K6976_RS07475 (K6976_07475) - 1526093..1526485 (+) 393 WP_000723888.1 conjugal transfer protein -
  K6976_RS07480 (K6976_07480) - 1526469..1528916 (+) 2448 WP_000331160.1 ATP-binding protein -
  K6976_RS07485 (K6976_07485) - 1528919..1531096 (+) 2178 WP_000804748.1 CD3337/EF1877 family mobilome membrane protein -
  K6976_RS07490 (K6976_07490) - 1531093..1532094 (+) 1002 WP_000769868.1 lysozyme family protein -
  K6976_RS07495 (K6976_07495) - 1532091..1533026 (+) 936 WP_001224320.1 conjugal transfer protein -
  K6976_RS11145 - 1533340..1533387 (+) 48 Protein_1441 hypothetical protein -
  K6976_RS07505 (K6976_07505) tet(M) 1533403..1535322 (+) 1920 WP_043029018.1 tetracycline resistance ribosomal protection protein Tet(M) -
  K6976_RS07510 (K6976_07510) - 1535441..1535608 (+) 168 WP_000336323.1 cysteine-rich KTR domain-containing protein -
  K6976_RS07515 (K6976_07515) - 1535668..1536021 (-) 354 WP_001227347.1 helix-turn-helix transcriptional regulator -
  K6976_RS07520 (K6976_07520) - 1536526..1536948 (+) 423 WP_000804885.1 sigma-70 family RNA polymerase sigma factor -
  K6976_RS07525 (K6976_07525) - 1536945..1537175 (+) 231 WP_000857133.1 helix-turn-helix domain-containing protein -
  K6976_RS10980 - 1537401..1537652 (-) 252 WP_001845478.1 hypothetical protein -
  K6976_RS07530 (K6976_07530) - 1537636..1537839 (+) 204 WP_000814511.1 excisionase -
  K6976_RS07535 (K6976_07535) - 1537921..1539138 (+) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  K6976_RS07540 (K6976_07540) - 1539355..1539627 (-) 273 WP_024414725.1 YlbG family protein -
  K6976_RS07545 (K6976_07545) clpP 1539754..1540344 (-) 591 WP_002937303.1 ATP-dependent Clp protease proteolytic subunit Regulator

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21494.74 Da        Isoelectric Point: 5.7110

>NTDB_id=599886 K6976_RS07545 WP_002937303.1 1539754..1540344(-) (clpP) [Streptococcus suis strain SS389]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSIIAQLLFLDAQDPTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGTAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNKLEKILADNSGK
TVKQIHKDAERDYWMSAEETLAYGFIDQIMDNTKVK

Nucleotide


Download         Length: 591 bp        

>NTDB_id=599886 K6976_RS07545 WP_002937303.1 1539754..1540344(-) (clpP) [Streptococcus suis strain SS389]
ATGATTCCAGTAGTTATTGAACAAACTAGCCGTGGTGAGCGCTCGTATGATATTTATTCCCGTTTGCTCAAGGATCGCAT
TATCATGTTGACAGGACCAGTTGAGGACAACATGGCAAACTCTATCATTGCACAATTGCTTTTCCTTGATGCCCAAGATC
CTACAAAGGATATTTACCTCTATGTTAATACGCCAGGAGGATCGGTGTCAGCAGGTCTAGCCATTGTAGACACGATGAAT
TTCATTAAAGCTGATGTTCAAACCATCGTTATGGGAACAGCTGCGAGCATGGGAACCATCATTGCATCAAGCGGTGCCAA
GGGCAAACGTTTCATGTTGCCAAATGCAGAGTACATGATTCACCAACCGATGGGTGGAACAGGTGGTGGCACTCAGCAAA
CAGACATGGCTATTGCAGCAGAACATCTATTAAAAACACGTAATAAGCTAGAAAAAATATTGGCAGATAATTCAGGTAAG
ACAGTCAAGCAAATCCATAAGGATGCAGAACGTGATTACTGGATGTCAGCAGAAGAAACCTTGGCTTACGGATTTATTGA
CCAGATTATGGACAATACAAAAGTCAAATAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0K2E545

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pyogenes JRS4

92.347

100

0.923
  clpP Streptococcus pyogenes MGAS315

92.347

100

0.923
  clpP Streptococcus mutans UA159

90.306

100

0.903
  clpP Streptococcus pneumoniae R6

88.776

100

0.888
  clpP Streptococcus pneumoniae Rx1

88.776

100

0.888
  clpP Streptococcus pneumoniae D39

88.776

100

0.888
  clpP Streptococcus pneumoniae TIGR4

88.776

100

0.888
  clpP Streptococcus thermophilus LMG 18311

88.776

100

0.888
  clpP Streptococcus thermophilus LMD-9

88.776

100

0.888
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

84.184

100

0.842
  clpP Lactococcus lactis subsp. cremoris KW2

83.673

100

0.837
  clpP Bacillus subtilis subsp. subtilis str. 168

58.163

100

0.582
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.549

98.469

0.577