Detailed information NTG0599878

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: K6976_RS04820
• Genome accession: NZ_CP082202
• Coordinates: 964740..965411 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain SS389
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 959740..970411

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6976_RS04790 (K6976_04790)	pstC	959797..960714 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
K6976_RS04795 (K6976_04795)	pstA	960704..961591 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
K6976_RS04800 (K6976_04800)	pstB	961616..962419 (+)	804	WP_024399032.1	phosphate ABC transporter ATP-binding protein PstB	-
K6976_RS04805 (K6976_04805)	pstB	962431..963189 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
K6976_RS04810 (K6976_04810)	phoU	963218..963874 (+)	657	WP_222760109.1	phosphate signaling complex protein PhoU	-
K6976_RS04815 (K6976_04815)	-	964040..964546 (+)	507	WP_024385292.1	hypothetical protein	-
K6976_RS04820 (K6976_04820)	ciaR	964740..965411 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
K6976_RS04825 (K6976_04825)	ciaH	965404..966783 (+)	1380	WP_105115720.1	cell wall metabolism sensor histidine kinase WalK	Regulator
K6976_RS04830 (K6976_04830)	-	966884..968113 (+)	1230	WP_202848624.1	transglutaminase domain-containing protein	-
K6976_RS04835 (K6976_04835)	rpsT	968376..968624 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
K6976_RS04840 (K6976_04840)	coaA	968683..969603 (-)	921	WP_002940857.1	type I pantothenate kinase	-
K6976_RS04845 (K6976_04845)	-	969712..970302 (+)	591	WP_024408790.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=599878 K6976_RS04820 WP_014637852.1 964740..965411(+) (ciaR) [Streptococcus suis strain SS389]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=599878 K6976_RS04820 WP_014637852.1 964740..965411(+) (ciaR) [Streptococcus suis strain SS389]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGCCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACCCCTGTTCTGATTACAACAGCC
AAAGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAATACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTAC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368