Detailed information NTG0059138

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: MSA_RS09920
• Genome accession: NC_021486
• Coordinates: 1916032..1916784 (-)
• Length: 250 a.a.
• NCBI ID: WP_001019939.1
• Uniprot ID: A0A0E1EJS7
• Organism: Streptococcus agalactiae ILRI005
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1911032..1921784

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MSA_RS11435 (MSA_20450)	-	1911733..1911915 (+)	183	WP_001866975.1	hypothetical protein	-
MSA_RS09900 (MSA_20460)	-	1911910..1913064 (-)	1155	WP_000623425.1	ABC transporter permease subunit	-
MSA_RS09905 (MSA_20470)	-	1913070..1913917 (-)	848	Protein_1881	ABC transporter ATP-binding protein	-
MSA_RS11440 (MSA_20480)	-	1913986..1914159 (-)	174	WP_000683600.1	hypothetical protein	-
MSA_RS09910 (MSA_20500)	-	1914448..1914612 (+)	165	Protein_1883	cysteine peptidase family C39 domain-containing protein	-
MSA_RS09915 (MSA_20520)	-	1914701..1916035 (-)	1335	WP_016481280.1	GHKL domain-containing protein	-
MSA_RS09920 (MSA_20530)	comE/blpR	1916032..1916784 (-)	753	WP_001019939.1	LytTR family transcriptional regulator DNA-binding domain-containing protein	Regulator
MSA_RS09925 (MSA_20550)	-	1917000..1917815 (-)	816	WP_016481281.1	endonuclease/exonuclease/phosphatase family protein	-
MSA_RS09930 (MSA_20560)	-	1917869..1920049 (-)	2181	WP_016481282.1	PTS transporter subunit IIBC	-

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29465.07 Da
• Isoelectric Point: 8.4441

>NTDB_id=59138 MSA_RS09920 WP_001019939.1 1916032..1916784(-) (comE/blpR) [Streptococcus agalactiae ILRI005]
MNIFILEDNFIQQARLERIIEEVKIRRSIHSKMVNTFEKPVQLLESICEKGMHNLYFLDIEIKNDEQRGLEVAKQIRQID
PYAQIVFVTTHSELMPLTFRYQVSALDYIDKGLSQEAFSRRIEEVLLYANNACSKNLLEDSFYFKSRYSQVQVPFNDILY
IETSLRSHRVVLYTAKDRMEFTATLGDILKQEPRLFQCHRSFLVNPLNIFKVDRSNKLIYLKNGSNCLISRNKIKDIMVV
IEENQRGRGI

Nucleotide

• Length: 753 bp

>NTDB_id=59138 MSA_RS09920 WP_001019939.1 1916032..1916784(-) (comE/blpR) [Streptococcus agalactiae ILRI005]
GTGAATATTTTTATTTTAGAGGATAATTTTATTCAACAGGCACGTTTAGAGAGAATAATTGAGGAAGTTAAAATTAGGAG
AAGTATACACAGTAAAATGGTAAATACCTTTGAAAAACCAGTTCAATTATTGGAATCAATCTGTGAAAAAGGTATGCATA
ATTTATATTTCTTAGACATTGAAATAAAAAATGATGAGCAGAGGGGCTTAGAGGTCGCAAAACAAATTAGACAAATTGAT
CCTTATGCTCAGATTGTTTTTGTTACAACTCATTCGGAATTAATGCCTTTAACCTTTCGTTATCAGGTATCAGCTTTAGA
CTATATCGATAAAGGACTTTCACAGGAAGCATTTAGCAGAAGGATTGAAGAAGTTTTACTATATGCTAATAATGCTTGCA
GTAAAAACTTACTAGAAGATTCTTTTTATTTTAAATCACGCTATAGTCAAGTACAAGTACCTTTTAACGATATCCTTTAT
ATAGAAACGTCATTAAGGTCACATAGAGTTGTCCTTTATACTGCAAAAGACAGAATGGAATTCACAGCCACTTTGGGGGA
TATTTTAAAACAAGAACCTAGGCTCTTTCAATGTCATCGCTCTTTTTTAGTAAATCCCTTGAATATTTTTAAAGTGGATA
GGTCAAATAAACTAATCTATTTAAAAAATGGTTCGAATTGTTTGATTTCTCGTAATAAAATAAAAGATATTATGGTAGTA
ATAGAGGAAAATCAAAGAGGTAGAGGAATATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-238)

3D structure

• AlphaFold DB: A0A0E1EJS7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	52.61	99.6	0.524
comE/comE1	Streptococcus equinus JB1	42.678	95.6	0.408
comE	Streptococcus pneumoniae D39	38.866	98.8	0.384
comE	Streptococcus pneumoniae R6	38.866	98.8	0.384
comE	Streptococcus pneumoniae TIGR4	38.866	98.8	0.384
comE	Streptococcus mitis SK321	38.866	98.8	0.384
comE	Streptococcus mitis NCTC 12261	38.866	98.8	0.384
comE	Streptococcus pneumoniae Rx1	38.866	98.8	0.384
comE	Streptococcus infantis strain Atu-4	36.8	100	0.368