NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	KX728_RS05785	Genome accession	NZ_CP079724
Coordinates	1171006..1171656 (-)	Length	216 a.a.
NCBI ID	WP_042902392.1	Uniprot ID	A0A081R6C3
Organism	Streptococcus oralis strain 34
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1166006..1176656

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KX728_RS05770 (KX728_05765)	-	1166612..1167796 (-)	1185	WP_042902389.1	membrane protein	-
KX728_RS05775 (KX728_05770)	-	1167793..1168386 (-)	594	WP_042902390.1	ATP-binding cassette domain-containing protein	-
KX728_RS09360	-	1168419..1168624 (-)	206	Protein_1100	hypothetical protein	-
KX728_RS05780 (KX728_05775)	comEC/celB	1168782..1171022 (-)	2241	WP_215804577.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
KX728_RS05785 (KX728_05780)	comEA/celA/cilE	1171006..1171656 (-)	651	WP_042902392.1	helix-hairpin-helix domain-containing protein	Machinery gene
KX728_RS05790 (KX728_05785)	-	1171723..1172292 (-)	570	WP_049485310.1	GNAT family N-acetyltransferase	-
KX728_RS05795 (KX728_05790)	ald	1172469..1173581 (+)	1113	WP_084921952.1	alanine dehydrogenase	-
KX728_RS05800 (KX728_05795)	-	1173632..1174618 (-)	987	WP_084921953.1	PhoH family protein	-
KX728_RS05805 (KX728_05800)	-	1174699..1174914 (-)	216	WP_001232084.1	YozE family protein	-
KX728_RS05810 (KX728_05805)	-	1174938..1175516 (-)	579	WP_215804576.1	GrpB family protein	-
KX728_RS05815 (KX728_05810)	cvfB	1175528..1176382 (-)	855	WP_215804575.1	S1 RNA-binding domain-containing protein	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23196.41 Da Isoelectric Point: 6.5099

                                >NTDB_id=588984 KX728_RS05785 WP_042902392.1 1171006..1171656(-) (comEA/celA/cilE) [Streptococcus oralis strain 34]

MEAIIEKIKEYKIIVICAGLGLALGGFFLLKPSTQKPVTETNLQAEVAAVSKDSSSEKEIKKEEKEESAEQDLITVDVKG

AVKSPGIYDLPVGSRVHDAVQKAGGLTDEADSKSLNLAQKVSDEALVYVPTKGEEAASQQAASGTTPSTSKDKKVNLNKA

SLEELKQVKGLGRKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=588984 KX728_RS05785 WP_042902392.1 1171006..1171656(-) (comEA/celA/cilE) [Streptococcus oralis strain 34]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATTGTCATCTGTGCTGGTTTGGGTTTGGCCTTGGGCGGATT

TTTCTTGCTAAAACCATCTACACAAAAACCCGTCACAGAAACAAATTTGCAGGCTGAAGTTGCAGCTGTTTCAAAGGATT

CATCATCTGAAAAGGAAATCAAGAAGGAAGAAAAGGAAGAATCTGCTGAACAAGATCTAATCACGGTAGATGTCAAAGGT

GCTGTTAAATCGCCAGGGATTTATGATTTGCCAGTAGGAAGTCGAGTTCATGATGCCGTTCAGAAGGCAGGTGGCTTGAC

AGATGAGGCAGATAGCAAGTCGCTCAATCTAGCACAGAAAGTCAGTGACGAGGCTCTTGTCTATGTTCCAACTAAGGGAG

AAGAAGCGGCTAGTCAGCAGGCTGCCTCAGGAACGACTCCTTCGACAAGTAAAGATAAGAAGGTCAACCTCAATAAAGCT

AGTCTGGAAGAACTCAAGCAGGTCAAAGGCTTGGGAAGAAAGCGAGCACAGGATATTATCGACCATCGTGAGGCAAATGG

CAAATTCAAGTCGGTAGATGAATTAAAGAAAGTCTCTGGTATTGGCGCTAAGACCATAGAAAAGCTAAAAGATTATGTCA

CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(152-214)

SLBB domain (SLBB)

(76-126)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A081R6C3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus mitis NCTC 12261	90.278	100	0.903
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	89.815	100	0.898
comEA/celA/cilE	Streptococcus pneumoniae D39	87.963	100	0.88
comEA/celA/cilE	Streptococcus pneumoniae R6	87.963	100	0.88
comEA/celA/cilE	Streptococcus pneumoniae Rx1	87.963	100	0.88
comEA/celA/cilE	Streptococcus mitis SK321	86.574	100	0.866
comEA	Lactococcus lactis subsp. cremoris KW2	41.441	100	0.426
comEA	Latilactobacillus sakei subsp. sakei 23K	33.906	100	0.366

Detailed information NTG0588984