Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   SPN034156_RS05970 Genome accession   NC_021006
Coordinates   1106134..1107315 (+) Length   393 a.a.
NCBI ID   WP_000681597.1    Uniprot ID   -
Organism   Streptococcus pneumoniae SPN034156     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1101134..1112315
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPN034156_RS05930 (SPN034156_10560) - 1102184..1102726 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  SPN034156_RS05945 (SPN034156_10570) comE 1102969..1103721 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  SPN034156_RS05950 (SPN034156_10580) comD/comD1 1103718..1105043 (-) 1326 WP_015511364.1 competence system sensor histidine kinase ComD Regulator
  SPN034156_RS05955 (SPN034156_10590) comC/comC1 1105064..1105189 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  SPN034156_RS05965 (SPN034156_10600) rlmH 1105472..1105951 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  SPN034156_RS05970 (SPN034156_10610) htrA 1106134..1107315 (+) 1182 WP_000681597.1 trypsin-like peptidase domain-containing protein Regulator
  SPN034156_RS05975 (SPN034156_10620) spo0J 1107373..1108131 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  SPN034156_RS05980 (SPN034156_10630) dnaA 1108344..1109705 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  SPN034156_RS05985 (SPN034156_10640) dnaN 1109864..1111000 (+) 1137 WP_000581155.1 DNA polymerase III subunit beta -
  SPN034156_RS05990 (SPN034156_10650) - 1111065..1111259 (+) 195 WP_000285194.1 DUF951 family protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41841.72 Da        Isoelectric Point: 6.8902

>NTDB_id=58043 SPN034156_RS05970 WP_000681597.1 1106134..1107315(+) (htrA) [Streptococcus pneumoniae SPN034156]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=58043 SPN034156_RS05970 WP_000681597.1 1106134..1107315(+) (htrA) [Streptococcus pneumoniae SPN034156]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCCGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

100

100

1
  htrA Streptococcus pneumoniae D39

100

100

1
  htrA Streptococcus pneumoniae R6

100

100

1
  htrA Streptococcus pneumoniae TIGR4

100

100

1
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.414

100

0.669
  htrA Streptococcus mutans UA159

54.569

100

0.547

Multiple sequence alignment