Detailed information NTG0058040

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: SPN034156_RS05945
• Genome accession: NC_021006
• Coordinates: 1102969..1103721 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae SPN034156
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1097969..1108721

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN034156_RS13090	-	1100402..1102005 (-)	1604	Protein_1090	YhgE/Pip domain-containing protein	-
SPN034156_RS05930 (SPN034156_10560)	-	1102184..1102726 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
SPN034156_RS05945 (SPN034156_10570)	comE	1102969..1103721 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
SPN034156_RS05950 (SPN034156_10580)	comD/comD1	1103718..1105043 (-)	1326	WP_015511364.1	competence system sensor histidine kinase ComD	Regulator
SPN034156_RS05955 (SPN034156_10590)	comC/comC1	1105064..1105189 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
SPN034156_RS05965 (SPN034156_10600)	rlmH	1105472..1105951 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
SPN034156_RS05970 (SPN034156_10610)	htrA	1106134..1107315 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
SPN034156_RS05975 (SPN034156_10620)	spo0J	1107373..1108131 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=58040 SPN034156_RS05945 WP_000866065.1 1102969..1103721(-) (comE) [Streptococcus pneumoniae SPN034156]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=58040 SPN034156_RS05945 WP_000866065.1 1102969..1103721(-) (comE) [Streptococcus pneumoniae SPN034156]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAAC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408