Detailed information NTG0580276

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: I6L85_RS05445
• Genome accession: NZ_CP077248
• Coordinates: 1091512..1092186 (-)
• Length: 224 a.a.
• NCBI ID: WP_008808730.1
• Uniprot ID: A0A0F2CMN1
• Organism: Streptococcus gordonii strain FDAARGOS 1455
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1086512..1097186

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6L85_RS05420 (I6L85_05420)	coaA	1086562..1087482 (+)	921	WP_105165144.1	type I pantothenate kinase	-
I6L85_RS05425 (I6L85_05425)	rpsT	1087579..1087827 (+)	249	WP_008808726.1	30S ribosomal protein S20	-
I6L85_RS05430 (I6L85_05430)	-	1087892..1088401 (+)	510	WP_008808727.1	DNA topology modulation protein	-
I6L85_RS05435 (I6L85_05435)	-	1088517..1089968 (+)	1452	WP_172455829.1	alpha-amylase	-
I6L85_RS05440 (I6L85_05440)	ciaH	1090116..1091522 (-)	1407	WP_111723686.1	cell wall metabolism sensor histidine kinase WalK	Regulator
I6L85_RS05445 (I6L85_05445)	ciaR	1091512..1092186 (-)	675	WP_008808730.1	response regulator transcription factor	Regulator
I6L85_RS05450 (I6L85_05450)	-	1092316..1092732 (-)	417	WP_111723685.1	hypothetical protein	-
I6L85_RS05455 (I6L85_05455)	-	1092916..1093719 (-)	804	WP_045634872.1	SDR family oxidoreductase	-
I6L85_RS05460 (I6L85_05460)	-	1093734..1094060 (-)	327	WP_083277171.1	multidrug efflux SMR transporter	-
I6L85_RS05465 (I6L85_05465)	-	1094111..1094395 (-)	285	WP_045634874.1	helix-turn-helix domain-containing protein	-
I6L85_RS05470 (I6L85_05470)	-	1094575..1097121 (-)	2547	WP_111723684.1	M1 family metallopeptidase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.07 Da
• Isoelectric Point: 4.3228

>NTDB_id=580276 I6L85_RS05445 WP_008808730.1 1091512..1092186(-) (ciaR) [Streptococcus gordonii strain FDAARGOS 1455]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLREKGVSTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVNGKEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNMQTLRSVGYILKNAE

Nucleotide

• Length: 675 bp

>NTDB_id=580276 I6L85_RS05445 WP_008808730.1 1091512..1092186(-) (ciaR) [Streptococcus gordonii strain FDAARGOS 1455]
ATGATTAAGATTTTACTAGTAGAAGATGACTTAGGGTTGTCGAACTCTGTATTTGATTTCTTAGATGACTTTGCGGATGT
CATGCAGGTTTTTGATGGTGAAGAAGGTCTCTATGAAGCTGAAAGCGGTGTTTATGATTTGATTCTACTGGATCTGATGC
TTCCTGAAAAAGACGGCTTTCAAGTTTTAAAAGACTTGCGTGAAAAAGGAGTCTCAACTCCTGTTCTCATCATGACTGCT
AAAGAAAGTTTGGATGATAAAGGACATGGCTTTGAATTAGGGGCAGATGACTATCTAACCAAGCCGTTTTATTTAGAAGA
ATTAAAGATGCGGATCCAGGCCTTACTCAAGCGTTCAGGAAAATTTAATGAAAATACTTTATCATATGGTGATGTGACAG
TAAATCTTTCTACCAATACCACTTTGGTGAATGGAAAAGAAGTAGAATTACTGGGAAAAGAATTTGATTTATTAGTTTAT
TTCCTGCAGAACCAAAACGTAATTCTACCTAAAACTCAGATTTTTGATCGGCTTTGGGGCTTTGACAGTGATACTACCAT
TTCTGTCGTTGAAGTCTATGTCTCAAAAATTCGGAAAAAATTGAAAGGAACGACTTTTGCGAACAATATGCAAACCCTTC
GCAGTGTCGGTTACATTTTGAAGAATGCTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

3D structure

• AlphaFold DB: A0A0F2CMN1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	90.625	100	0.906
ciaR	Streptococcus pneumoniae D39	90.625	100	0.906
ciaR	Streptococcus pneumoniae R6	90.625	100	0.906
ciaR	Streptococcus pneumoniae TIGR4	90.625	100	0.906
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.362
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362