NTDB

Overview

Name	vicR	Type	Regulator
Locus tag	KRG72_RS06740	Genome accession	NZ_CP076703
Coordinates	1360438..1361148 (-)	Length	236 a.a.
NCBI ID	WP_039696509.1	Uniprot ID	A0A6G8HYC0
Organism	Streptococcus equinus strain S1
Function	repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1355438..1366148

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KRG72_RS06725 (KRG72_06735)	rnc	1357375..1358061 (-)	687	WP_020917219.1	ribonuclease III	-
KRG72_RS06730 (KRG72_06740)	vicX	1358283..1359092 (-)	810	WP_258250301.1	MBL fold metallo-hydrolase	Regulator
KRG72_RS06735 (KRG72_06745)	vicK	1359093..1360445 (-)	1353	WP_039696510.1	cell wall metabolism sensor histidine kinase VicK	Regulator
KRG72_RS06740 (KRG72_06750)	vicR	1360438..1361148 (-)	711	WP_039696509.1	response regulator YycF	Regulator
KRG72_RS06745 (KRG72_06755)	-	1361460..1362224 (+)	765	WP_039696508.1	amino acid ABC transporter ATP-binding protein	-
KRG72_RS06750 (KRG72_06760)	-	1362235..1363047 (+)	813	WP_074602531.1	transporter substrate-binding domain-containing protein	-
KRG72_RS06755 (KRG72_06765)	-	1363063..1363770 (+)	708	WP_039696506.1	amino acid ABC transporter permease	-
KRG72_RS06760 (KRG72_06770)	-	1363783..1364430 (+)	648	WP_006532766.1	amino acid ABC transporter permease	-
KRG72_RS06765 (KRG72_06775)	-	1364468..1365076 (-)	609	WP_006532767.1	TVP38/TMEM64 family protein	-
KRG72_RS06770 (KRG72_06780)	-	1365289..1365591 (-)	303	WP_258250302.1	hypothetical protein	-

Sequence

Protein

Download Length: 236 a.a. Molecular weight: 27121.90 Da Isoelectric Point: 4.7040

                                >NTDB_id=577472 KRG72_RS06740 WP_039696509.1 1360438..1361148(-) (vicR) [Streptococcus equinus strain S1]

MKKILIVDDEKPISDIIKFNLTKEGYETVTAFDGREAIAKFEEENPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIESAVAEENASSSNSEITIGDLKILPDAFVAQKRGEDIE

LTHREFELLHHLATHMGQVMTREYLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMKSYE

Nucleotide

Download Length: 711 bp

                                >NTDB_id=577472 KRG72_RS06740 WP_039696509.1 1360438..1361148(-) (vicR) [Streptococcus equinus strain S1]

ATGAAAAAAATTCTTATTGTTGATGATGAAAAACCAATTTCAGATATTATTAAATTTAACTTAACTAAAGAAGGTTATGA

AACTGTTACGGCTTTTGATGGTCGTGAAGCAATTGCTAAATTTGAAGAAGAAAATCCTGATTTGATTATCTTGGATTTGA

TGTTGCCAGAATTGGATGGACTTGAAGTTGCAAAAGAAGTTCGTAAAACAAGTCATATTCCGATTATTATGCTTTCTGCA

AAAGATAGTGAGTTCGATAAAGTTATCGGTCTTGAAATCGGTGCAGATGACTACGTCACAAAACCTTTCTCAAATCGTGA

ATTGTTAGCACGTGTCAAAGCACACCTTCGTCGTACTGAGAACATCGAATCAGCCGTCGCTGAGGAAAATGCTTCTTCAT

CAAATTCTGAAATTACCATCGGCGATTTGAAGATTTTGCCTGATGCCTTTGTTGCCCAAAAACGTGGCGAAGACATTGAA

TTAACACACCGTGAATTTGAATTACTTCATCACTTAGCTACTCACATGGGACAAGTGATGACGCGTGAATACCTTTTGGA

GACTGTTTGGGGTTATGATTACTTTGGTGATGTTCGCACGGTTGACGTTACCATCCGTCGTTTACGTGAAAAAATCGAAG

ACACTCCGAGCCGTCCAGAATACATTTTGACACGTCGCGGTGTTGGATACTACATGAAGTCTTATGAATGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A6G8HYC0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
vicR	Streptococcus mutans UA159	90.678	100	0.907
micA	Streptococcus pneumoniae Cp1015	78.205	99.153	0.775
covR	Streptococcus salivarius strain HSISS4	46.983	98.305	0.462
covR	Lactococcus lactis subsp. lactis strain DGCC12653	45.69	98.305	0.449
scnR	Streptococcus mutans UA159	36.441	100	0.364

Detailed information NTG0577472