NTDB

Overview

Name	comE/comE2	Type	Regulator
Locus tag	KIP81_RS08795	Genome accession	NZ_CP075172
Coordinates	1771372..1772100 (-)	Length	242 a.a.
NCBI ID	WP_024343524.1	Uniprot ID	A0A1G9NQG7
Organism	Streptococcus equinus strain SheepZ001
Function	activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1766372..1777100

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KIP81_RS08765 (KIP81_08755)	-	1766708..1767649 (-)	942	WP_074480707.1	3'-5' exoribonuclease YhaM family protein	-
KIP81_RS08770 (KIP81_08760)	-	1767639..1768913 (-)	1275	WP_243602835.1	DNA recombination protein RmuC	-
KIP81_RS08775 (KIP81_08765)	-	1768916..1769548 (-)	633	WP_243602836.1	thiamine diphosphokinase	-
KIP81_RS08780 (KIP81_08770)	rpe	1769541..1770203 (-)	663	WP_024343526.1	ribulose-phosphate 3-epimerase	-
KIP81_RS08785 (KIP81_08775)	rsgA	1770210..1771082 (-)	873	WP_027968346.1	ribosome small subunit-dependent GTPase A	-
KIP81_RS08795 (KIP81_08785)	comE/comE2	1771372..1772100 (-)	729	WP_024343524.1	LytTR family DNA-binding domain-containing protein	Regulator
KIP81_RS08800 (KIP81_08790)	comD/comD3	1772718..1774109 (-)	1392	WP_243602837.1	GHKL domain-containing protein	Regulator
KIP81_RS08805 (KIP81_08795)	comD/comD3	1774102..1775118 (-)	1017	WP_243602838.1	GHKL domain-containing protein	Regulator
KIP81_RS08810 (KIP81_08800)	comD/comD3	1775487..1776866 (-)	1380	WP_243602839.1	GHKL domain-containing protein	Regulator
KIP81_RS08815 (KIP81_08805)	-	1776873..1777070 (-)	198	WP_243602840.1	hypothetical protein	-

Sequence

Protein

Download Length: 242 a.a. Molecular weight: 28281.51 Da Isoelectric Point: 6.4962

                                >NTDB_id=568266 KIP81_RS08795 WP_024343524.1 1771372..1772100(-) (comE/comE2) [Streptococcus equinus strain SheepZ001]

MIDIYVLEDNVNQQFRIERMIDELLDENQWDYRHFEIFSEPSHFPNFVEESCPQIFFLDIDINGDNKKGIEVAKKIREKS

RTATIVFVTTHSEFMLLTYRAQVSALDFIDKADEDSSIKINLKNCLRKVIENQALTMPQEFFVFENNKATIRIPMDEILY

FETAESHRLKLVTKSGQRNFYGSIKEVMAANQTFFRSHKSYLINLDNVVCLDKKNSLVHFVGGQSCLVSKKYIKELKLKI

GV

Nucleotide

Download Length: 729 bp

                                >NTDB_id=568266 KIP81_RS08795 WP_024343524.1 1771372..1772100(-) (comE/comE2) [Streptococcus equinus strain SheepZ001]

ATGATTGACATCTATGTATTGGAGGACAATGTAAATCAGCAATTTCGGATTGAAAGGATGATTGATGAACTACTCGATGA

AAATCAGTGGGACTATCGTCATTTTGAAATATTTAGTGAGCCGTCTCATTTTCCAAATTTTGTTGAGGAATCTTGCCCAC

AAATTTTTTTCTTAGATATTGATATCAATGGTGATAATAAAAAGGGAATTGAAGTCGCTAAGAAAATTAGGGAGAAATCT

AGAACAGCTACGATTGTTTTTGTTACAACGCATTCTGAGTTTATGTTGTTGACTTACCGAGCACAGGTTAGTGCACTTGA

TTTTATTGATAAGGCAGATGAAGACAGTTCGATAAAAATTAATTTAAAAAATTGTTTGCGAAAGGTCATCGAAAATCAGG

CTCTTACGATGCCACAGGAATTTTTTGTATTTGAAAATAATAAAGCTACTATTCGTATTCCGATGGATGAAATTCTTTAT

TTTGAAACAGCTGAAAGTCATCGACTGAAGTTGGTTACAAAGTCGGGACAACGTAATTTTTATGGTTCAATCAAAGAAGT

AATGGCTGCTAATCAGACCTTTTTTAGAAGCCACAAATCATATCTGATTAATCTTGATAATGTTGTGTGCTTAGATAAAA

AGAATAGTTTGGTGCATTTTGTCGGTGGTCAATCTTGCCTTGTTTCAAAGAAATACATTAAAGAATTAAAGTTGAAAATA

GGTGTTTAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(6-114)

LytTr DNA-binding domain (LytTR)

(149-239)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A1G9NQG7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/comE2	Streptococcus equinus JB1	74.167	99.174	0.736
comE/comE1	Streptococcus equinus JB1	44.118	98.347	0.434
comE/blpR	Streptococcus mutans UA159	39.754	100	0.401
comE/comE2	Streptococcus gordonii strain NCTC7865	38.367	100	0.388
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.367	100	0.388

Detailed information NTG0568266