NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	KIP81_RS05045	Genome accession	NZ_CP075172
Coordinates	1006069..1006743 (-)	Length	224 a.a.
NCBI ID	WP_074450515.1	Uniprot ID	A0A1G9I8L9
Organism	Streptococcus equinus strain SheepZ001
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1001069..1011743

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KIP81_RS05020 (KIP81_05020)	deoC	1001551..1002216 (-)	666	WP_243602473.1	deoxyribose-phosphate aldolase	-
KIP81_RS05025 (KIP81_05025)	-	1002719..1003309 (-)	591	WP_243602474.1	class I SAM-dependent methyltransferase	-
KIP81_RS05030 (KIP81_05030)	coaA	1003423..1004343 (+)	921	WP_033152659.1	type I pantothenate kinase	-
KIP81_RS05035 (KIP81_05035)	rpsT	1004419..1004670 (+)	252	WP_004231769.1	30S ribosomal protein S20	-
KIP81_RS05040 (KIP81_05040)	ciaH	1004754..1006079 (-)	1326	WP_243602475.1	HAMP domain-containing sensor histidine kinase	Regulator
KIP81_RS05045 (KIP81_05045)	ciaR	1006069..1006743 (-)	675	WP_074450515.1	response regulator transcription factor	Regulator
KIP81_RS05050 (KIP81_05050)	-	1006897..1009440 (-)	2544	WP_243602476.1	M1 family metallopeptidase	-
KIP81_RS05055 (KIP81_05055)	phoU	1009649..1010302 (-)	654	WP_024344053.1	phosphate signaling complex protein PhoU	-
KIP81_RS05060 (KIP81_05060)	pstB	1010334..1011092 (-)	759	WP_243602477.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25373.98 Da Isoelectric Point: 4.3369

                                >NTDB_id=568250 KIP81_RS05045 WP_074450515.1 1006069..1006743(-) (ciaR) [Streptococcus equinus strain SheepZ001]

MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGAEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGISTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNNNTLSYHELTADTSTNTTTVNGEKVELLGKEFDLLVY

FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTSFADNLQTLRSVGYILKDAE

Nucleotide

Download Length: 675 bp

                                >NTDB_id=568250 KIP81_RS05045 WP_074450515.1 1006069..1006743(-) (ciaR) [Streptococcus equinus strain SheepZ001]

ATGATTAAAATTTTATTAGTAGAAGACGATTTGAGCTTGTCAAATTCAATTTTTGATTTTTTGGATGATTTTGCGGATGT

CATGCAGGTTTTTGATGGCGCAGAAGGTTTATATGAAGCAGAAAGTGGTGTTTATGACCTTATTTTGCTTGATTTGATGT

TGCCAGAAAAAGATGGTTTCCAAGTTCTTAAAGAATTACGTGAAAAAGGCATTTCAACACCTGTTTTGATTATGACAGCT

AAAGAAAGTCTTGATGACAAAGGACATGGATTCGAATTAGGTGCTGATGATTACCTAACAAAACCATTTTATCTTGAAGA

ACTTAAGATGCGTATTCAAGCTCTTTTAAAACGTTCAGGTAAATTTAATAACAATACTTTGTCATATCATGAATTAACTG

CGGATACTTCAACAAATACAACAACCGTTAATGGTGAAAAAGTTGAATTACTAGGTAAAGAGTTTGATTTGTTAGTATAC

TTTTTACAAAACCAAAATGTCATTTTGCCAAAATCACAAATTTTTGATCGTATTTGGGGCTTTGACAGTGATACAACAAT

TTCAGTTGTTGAAGTATATGTTTCAAAAATTCGTAAAAAACTCAAAGGTACTAGTTTTGCCGATAATCTTCAAACACTAC

GTAGTGTAGGTTACATATTGAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A1G9I8L9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	91.928	99.554	0.915
ciaR	Streptococcus pneumoniae Rx1	87.5	100	0.875
ciaR	Streptococcus pneumoniae D39	87.5	100	0.875
ciaR	Streptococcus pneumoniae R6	87.5	100	0.875
ciaR	Streptococcus pneumoniae TIGR4	87.5	100	0.875
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.767	100	0.393
micA	Streptococcus pneumoniae Cp1015	34.764	100	0.362
vicR	Streptococcus mutans UA159	34.764	100	0.362

Detailed information NTG0568250