Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   MK801_RS03435 Genome accession   NZ_CP092748
Coordinates   657064..657732 (+) Length   222 a.a.
NCBI ID   WP_021722129.1    Uniprot ID   -
Organism   Lactococcus lactis strain 17M1     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 652064..662732
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MK801_RS03425 (MK801_03425) - 653504..655759 (+) 2256 WP_128267544.1 glycoside hydrolase family 65 protein -
  MK801_RS03430 (MK801_03430) - 655912..656886 (+) 975 WP_003130365.1 LacI family DNA-binding transcriptional regulator -
  MK801_RS03435 (MK801_03435) ciaR 657064..657732 (+) 669 WP_021722129.1 response regulator transcription factor Regulator
  MK801_RS03440 (MK801_03440) ciaH 657826..659196 (+) 1371 WP_042230545.1 cell wall metabolism sensor histidine kinase WalK Regulator
  MK801_RS03445 (MK801_03445) - 659344..661086 (+) 1743 WP_254255720.1 1-deoxy-D-xylulose-5-phosphate synthase -
  MK801_RS03450 (MK801_03450) yidD 661203..661469 (+) 267 WP_012898265.1 membrane protein insertion efficiency factor YidD -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25516.42 Da        Isoelectric Point: 4.4864

>NTDB_id=568033 MK801_RS03435 WP_021722129.1 657064..657732(+) (ciaR) [Lactococcus lactis strain 17M1]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=568033 MK801_RS03435 WP_021722129.1 657064..657732(+) (ciaR) [Lactococcus lactis strain 17M1]
ATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTATGATTTCTTAAAATCATTTGCGCAAGT
CAAACAGGTTTATGATGGTGTTGAAGGACTCTATGAGGCAGAATTGGGAATCTATGATTTAATTTTGCTTGATTTAATGC
TTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACGCCAGTCTTAATCATGACTGCT
AAAGAATCTTTGGATGATAAAATGCACGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTGACTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGATTTAGTCGTT
TATTTAATGCAAAATCAAAATGTTATTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGCTATGACAGTGATACAAC
AGTTACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACCT
TGCGAAATGTTGGCTATATCCTGAGATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

74.775

100

0.748
  ciaR Streptococcus pneumoniae D39

74.775

100

0.748
  ciaR Streptococcus pneumoniae R6

74.775

100

0.748
  ciaR Streptococcus pneumoniae TIGR4

74.775

100

0.748
  ciaR Streptococcus mutans UA159

72.973

100

0.73
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.392
  covR Streptococcus salivarius strain HSISS4

37.333

100

0.378
  vicR Streptococcus mutans UA159

34.764

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.483

100

0.36