Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV33_RS12980 | Genome accession | NZ_CP073850 |
| Coordinates | 2648151..2649512 (+) | Length | 453 a.a. |
| NCBI ID | WP_001631036.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1266911 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602476..2651137 | 2648151..2649512 | within | 0 |
Gene organization within MGE regions
Location: 2602476..2651137
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV33_RS12730 (KFV33_12740) | ccrA | 2602476..2603822 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV33_RS12735 (KFV33_12745) | ccrB | 2603843..2605471 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV33_RS12740 (KFV33_12750) | - | 2605942..2606292 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV33_RS12745 (KFV33_12755) | - | 2606377..2606688 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV33_RS12750 (KFV33_12760) | - | 2606707..2607228 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV33_RS12755 (KFV33_12765) | - | 2607230..2607436 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV33_RS12760 (KFV33_12770) | - | 2607429..2607752 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV33_RS12765 (KFV33_12775) | - | 2607947..2609839 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV33_RS12770 (KFV33_12780) | - | 2609846..2610223 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV33_RS12775 (KFV33_12785) | - | 2610461..2610826 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV33_RS12780 (KFV33_12790) | - | 2610819..2613233 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV33_RS12785 (KFV33_12795) | - | 2613314..2613930 (+) | 617 | Protein_2484 | CadD family cadmium resistance transporter | - |
| KFV33_RS12795 (KFV33_12805) | - | 2614204..2614842 (-) | 639 | Protein_2485 | sulfite exporter TauE/SafE family protein | - |
| KFV33_RS12800 (KFV33_12810) | cstR | 2614842..2615102 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV33_RS12805 (KFV33_12815) | - | 2615238..2616302 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV33_RS12810 (KFV33_12820) | cstB | 2616335..2617669 (+) | 1335 | Protein_2488 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV33_RS12815 (KFV33_12825) | - | 2617783..2618892 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV33_RS12820 (KFV33_12830) | psm-mec | 2619247..2619315 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV33_RS12825 (KFV33_12835) | mecI | 2619400..2619771 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV33_RS12830 (KFV33_12840) | mecR1 | 2619771..2621528 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV33_RS12835 (KFV33_12845) | mecA | 2621625..2623634 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV33_RS12840 (KFV33_12850) | - | 2623680..2624108 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV33_RS12845 (KFV33_12855) | - | 2624205..2624948 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV33_RS12850 (KFV33_12860) | - | 2625745..2626134 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV33_RS12855 (KFV33_12865) | - | 2626170..2626844 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV33_RS12860 (KFV33_12870) | - | 2627289..2628545 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV33_RS12865 (KFV33_12875) | - | 2628988..2629533 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV33_RS12870 (KFV33_12880) | - | 2629551..2629760 (-) | 210 | Protein_2500 | heavy metal translocating P-type ATPase | - |
| KFV33_RS12875 (KFV33_12885) | - | 2629930..2630688 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV33_RS12880 (KFV33_12890) | - | 2630685..2630840 (-) | 156 | Protein_2502 | metal-sensing transcriptional repressor | - |
| KFV33_RS12890 (KFV33_12900) | - | 2631063..2631353 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV33_RS12895 (KFV33_12905) | - | 2631405..2632277 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV33_RS12900 (KFV33_12910) | - | 2632447..2632893 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV33_RS12905 (KFV33_12915) | - | 2632921..2633427 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV33_RS12910 (KFV33_12920) | - | 2633443..2633754 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV33_RS12915 (KFV33_12925) | - | 2633850..2634188 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV33_RS12920 (KFV33_12930) | - | 2634294..2635970 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV33_RS12925 (KFV33_12935) | - | 2636197..2637840 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV33_RS12930 (KFV33_12940) | - | 2637837..2638208 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV33_RS12935 (KFV33_12945) | - | 2638201..2639301 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV33_RS12940 (KFV33_12950) | - | 2639528..2641003 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV33_RS12945 (KFV33_12955) | - | 2641111..2641974 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV33_RS12950 (KFV33_12960) | - | 2642172..2642477 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV33_RS12955 (KFV33_12965) | - | 2643729..2645654 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV33_RS12960 (KFV33_12970) | - | 2645984..2646310 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV33_RS12965 (KFV33_12975) | - | 2646517..2646876 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV33_RS12970 (KFV33_12980) | - | 2646988..2647326 (-) | 339 | Protein_2519 | recombinase family protein | - |
| KFV33_RS12975 (KFV33_12985) | - | 2647335..2647964 (+) | 630 | Protein_2520 | hypothetical protein | - |
| KFV33_RS12980 (KFV33_12990) | ccrA | 2648151..2649512 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV33_RS12985 (KFV33_12995) | ccrB | 2649509..2651137 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 453 a.a. Molecular weight: 53316.45 Da Isoelectric Point: 9.8596
>NTDB_id=561413 KFV33_RS12980 WP_001631036.1 2648151..2649512(+) (ccrA) [Staphylococcus epidermidis strain B1266911]
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
MEEAIAYVRQSTLKQQSLATQKSLIMDTAKQYGWSNVAFYDDKKTGRHTKRSGYQKMVEIITSGKCKVLCCYRLNRLHRN
LKNAIQFFEICKKHHITIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTKNGIREKAKQGKLITTHAPFGYRYR
KGCFVVQEEEAYTVKSVYRWYLQGLGYKKISQHLDSNPNLIPRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIIDIDT
FEEAQERRIHKQLNRSNSRNKLKRRIKCPYCQSTLTNLTIKKENYSLRYYVCPKNMNDAYRTCPFKSINAPELESEVLDT
CKKYFEEQSFHKRLNNTILKVLKQQQMKHKETHLTQEQLIEKLAQNRIDVKTFKRLSASCKSEENYSTYSTYQIDDKLKY
VIKNKITLQDIAPFIDCIKITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI
Nucleotide
Download Length: 1362 bp
>NTDB_id=561413 KFV33_RS12980 WP_001631036.1 2648151..2649512(+) (ccrA) [Staphylococcus epidermidis strain B1266911]
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
ATGGAAGAAGCGATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCTACTCAAAAATCGCTCATTATGGA
TACCGCTAAGCAATATGGATGGTCTAATGTGGCGTTTTATGATGATAAGAAAACAGGTCGACATACAAAACGTTCAGGTT
ATCAAAAAATGGTAGAAATAATTACGTCTGGAAAATGTAAAGTATTGTGTTGCTATCGCTTGAACCGACTACATCGTAAT
TTGAAAAATGCCATACAATTCTTTGAAATTTGTAAAAAGCATCACATCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGTTTGAACATACTTATGAGTCTAGCGGAAATGGAATCAAACAATATCAGCGAAC
AAACAAAAAATGGGATTAGAGAAAAAGCCAAACAAGGTAAGCTAATCACAACTCATGCTCCGTTTGGCTATCGTTATAGA
AAAGGTTGTTTTGTTGTACAAGAAGAAGAAGCGTATACAGTTAAATCGGTTTATCGCTGGTACTTACAAGGTCTAGGCTA
CAAAAAGATTTCCCAACATTTGGATAGTAATCCTAACCTTATTCCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGCGGTCGTGTCATCAATAAATATGGCACGTTTAATGATATCGTTCCACCTATTATTGATATTGATACA
TTTGAAGAAGCACAAGAGCGTCGTATTCATAAACAACTCAATCGATCCAATTCTAGAAATAAGCTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAGAACTATTCTCTACGTTACTATGTTTGTCCTA
AAAATATGAATGACGCTTATCGTACATGCCCATTTAAAAGTATCAATGCACCAGAACTTGAAAGTGAAGTGCTCGACACT
TGTAAAAAGTATTTTGAAGAACAATCGTTTCATAAACGATTGAATAACACAATACTCAAAGTCCTAAAACAGCAACAAAT
GAAGCATAAAGAAACCCATCTAACACAAGAACAACTTATCGAAAAGCTAGCTCAAAATCGTATTGATGTAAAAACGTTCA
AACGTTTATCTGCTAGTTGTAAAAGTGAAGAGAATTACTCTACTTATTCAACCTACCAAATCGATGACAAATTAAAATAT
GTCATAAAAAATAAAATAACTTTACAGGATATAGCACCTTTTATCGATTGCATCAAAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCACATTTAATAACTCCTGAAAGGAATGAAGTAATAT
GA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
54.628 |
97.792 |
0.534 |
| ccrA | Staphylococcus aureus N315 |
50.564 |
97.792 |
0.494 |