Detailed information NTG0557822

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: INT76_RS02170
• Genome accession: NZ_CP073084
• Coordinates: 450117..450791 (-)
• Length: 224 a.a.
• NCBI ID: WP_212571703.1
• Uniprot ID: -
• Organism: Streptococcus oriscaviae strain HKU75
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 445117..455791

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
INT76_RS02145 (INT76_02145)	-	445375..445965 (-)	591	WP_212571695.1	class I SAM-dependent methyltransferase	-
INT76_RS02150 (INT76_02150)	coaA	446040..446963 (+)	924	WP_212571697.1	type I pantothenate kinase	-
INT76_RS02155 (INT76_02155)	rpsT	447021..447269 (+)	249	WP_212572993.1	30S ribosomal protein S20	-
INT76_RS02160 (INT76_02160)	-	447384..448628 (-)	1245	WP_212571699.1	transglutaminase domain-containing protein	-
INT76_RS02165 (INT76_02165)	ciaH	448739..450127 (-)	1389	WP_212571701.1	HAMP domain-containing sensor histidine kinase	Regulator
INT76_RS02170 (INT76_02170)	ciaR	450117..450791 (-)	675	WP_212571703.1	response regulator transcription factor	Regulator
INT76_RS02175 (INT76_02175)	-	450845..451249 (-)	405	WP_212571705.1	hypothetical protein	-
INT76_RS11135 (INT76_02180)	-	451599..452510 (-)	912	WP_212571707.1	LPXTG cell wall anchor domain-containing protein	-
INT76_RS02185 (INT76_02185)	-	452549..453808 (-)	1260	WP_212571708.1	hypothetical protein	-
INT76_RS02190 (INT76_02190)	phoU	454130..454786 (-)	657	WP_212571710.1	phosphate signaling complex protein PhoU	-
INT76_RS02195 (INT76_02195)	pstB	454841..455599 (-)	759	WP_212571712.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25298.93 Da
• Isoelectric Point: 4.2081

>NTDB_id=557822 INT76_RS02170 WP_212571703.1 450117..450791(-) (ciaR) [Streptococcus oriscaviae strain HKU75]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGITTPVLITTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVSVDLSTNSTLVNGVEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTAFGENLQTLRSVGYILKNVE

Nucleotide

• Length: 675 bp

>NTDB_id=557822 INT76_RS02170 WP_212571703.1 450117..450791(-) (ciaR) [Streptococcus oriscaviae strain HKU75]
ATGATTAAGATATTGTTAGTTGAAGATGATCTCAGTCTTTCAAATTCCGTCTTTGATTTCCTAGATGATTTTGCAGATGT
TATGCAGGTTTTTGATGGTGACGAAGGTCTTTATGAAGCCGAATCAGGGGTGTATGATTTGATTTTGCTGGACTTGATGT
TGCCTGAAAAGGACGGATTCCAAGTCTTGAAGGAATTGCGTGAAAAAGGCATCACCACGCCAGTTCTCATTACCACTGCA
AAAGAAAGTCTTGATGACAAGGGACATGGATTTGAGTTGGGAGCCGATGACTACTTGACCAAACCATTCTACCTAGAAGA
GCTAAAAATGCGTATTCAGGCCTTGTTGAAACGCGCTGGGAAATTCAATGAGAATACTCTTTCTTATGGCGATGTTTCGG
TTGATCTTTCAACTAACTCTACCTTAGTCAACGGTGTTGAAGTGGAGCTTTTGGGCAAGGAATTTGATTTGCTAGTGTAT
TTCCTACAAAATCAAAATGTTATCCTGCCTAAGACACAAATTTTCGACCGCATTTGGGGCTTTGACAGCGATACGACTAT
TTCGGTCGTTGAGGTCTACGTTTCTAAAATAAGAAAAAAATTGAAAGGTACCGCCTTTGGAGAGAACCTACAAACTCTCC
GTAGTGTTGGTTACATTTTGAAGAATGTTGAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	89.286	100	0.893
ciaR	Streptococcus pneumoniae Rx1	89.286	100	0.893
ciaR	Streptococcus pneumoniae D39	89.286	100	0.893
ciaR	Streptococcus pneumoniae R6	89.286	100	0.893
ciaR	Streptococcus mutans UA159	89.686	99.554	0.893
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.381	100	0.397
vicR	Streptococcus mutans UA159	35.897	100	0.375
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.366