NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	J5M87_RS05465	Genome accession	NZ_CP072115
Coordinates	1126849..1127523 (-)	Length	224 a.a.
NCBI ID	WP_154607994.1	Uniprot ID	A0A6I4RBC4
Organism	Streptococcus zhangguiae strain zg-86
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1121849..1132523

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J5M87_RS05445 (J5M87_05445)	rpsT	1122259..1122507 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
J5M87_RS05450 (J5M87_05450)	-	1122566..1123075 (+)	510	WP_154607991.1	DNA topology modulation protein	-
J5M87_RS05455 (J5M87_05455)	-	1123106..1124872 (-)	1767	WP_154607992.1	flavocytochrome c	-
J5M87_RS05460 (J5M87_05460)	ciaH	1125465..1126859 (-)	1395	WP_154607993.1	cell wall metabolism sensor histidine kinase WalK	Regulator
J5M87_RS05465 (J5M87_05465)	ciaR	1126849..1127523 (-)	675	WP_154607994.1	response regulator transcription factor	Regulator
J5M87_RS05470 (J5M87_05470)	phoU	1127930..1128586 (-)	657	WP_154607995.1	phosphate signaling complex protein PhoU	-
J5M87_RS05475 (J5M87_05475)	pstB	1128605..1129363 (-)	759	WP_154607996.1	phosphate ABC transporter ATP-binding protein PstB	-
J5M87_RS05480 (J5M87_05480)	pstB	1129376..1130179 (-)	804	WP_154607997.1	phosphate ABC transporter ATP-binding protein PstB	-
J5M87_RS05485 (J5M87_05485)	pstA	1130195..1131082 (-)	888	WP_154632441.1	phosphate ABC transporter permease PstA	-
J5M87_RS05490 (J5M87_05490)	pstC	1131072..1131989 (-)	918	WP_154607998.1	phosphate ABC transporter permease subunit PstC	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25264.96 Da Isoelectric Point: 4.3719

                                >NTDB_id=550541 J5M87_RS05465 WP_154607994.1 1126849..1127523(-) (ciaR) [Streptococcus zhangguiae strain zg-86]

MIKILLVEDDISLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFQVLKELRAKGITTPVLITTA

KESIDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFSQNTLTFGELSVDLSTNTATINGKEVELLGKEFDLLLY

FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTAFGEQLHTLRSVGYILKNAD

Nucleotide

Download Length: 675 bp

                                >NTDB_id=550541 J5M87_RS05465 WP_154607994.1 1126849..1127523(-) (ciaR) [Streptococcus zhangguiae strain zg-86]

ATGATTAAGATTTTATTAGTAGAAGATGATATCAGTTTATCCAATTCAGTCTTTGATTTTTTAGATGATTTTGCAGATGT

GATGCAGGTATTTGACGGAGATGAGGGGTTATATGAGGCAGAATCAGGAGTATATGACCTCATCTTGCTCGATTTGATGT

TGCCGGAAAAAGACGGCTTTCAAGTTCTGAAAGAACTAAGGGCTAAGGGGATTACAACGCCTGTTCTGATTACAACCGCT

AAGGAAAGTATAGACGATAAGGGGCATGGTTTTGAGCTTGGAGCAGATGACTATCTAACCAAACCCTTTTATTTGGAAGA

GTTGAAGATGCGGATTCAGGCCCTTTTGAAACGCTCTGGAAAGTTCAGTCAAAATACCCTCACCTTTGGAGAACTGTCTG

TGGACCTTTCAACCAATACAGCTACCATAAATGGGAAAGAAGTCGAACTCTTAGGAAAAGAGTTTGATTTACTACTCTAT

TTCTTGCAGAATCAAAATGTCATTTTACCAAAGACACAAATTTTTGACCGAATTTGGGGTTTTGATAGTGATACCACTAT

TTCAGTTGTGGAAGTATATGTCTCTAAAATTAGAAAAAAATTGAAAGGGACGGCCTTTGGGGAGCAATTGCATACCCTAC

GGAGTGTCGGTTATATCTTGAAAAATGCTGATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A6I4RBC4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	87.5	100	0.875
ciaR	Streptococcus pneumoniae Rx1	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae D39	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae R6	86.099	99.554	0.857
ciaR	Streptococcus pneumoniae TIGR4	86.099	99.554	0.857
vicR	Streptococcus mutans UA159	36.441	100	0.384
covR	Lactococcus lactis subsp. lactis strain DGCC12653	37.333	100	0.375
micA	Streptococcus pneumoniae Cp1015	35.193	100	0.366

Detailed information NTG0550541