Detailed information NTG0550540

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: J5M87_RS05460
• Genome accession: NZ_CP072115
• Coordinates: 1125465..1126859 (-)
• Length: 464 a.a.
• NCBI ID: WP_154607993.1
• Uniprot ID: A0A6I4RGI1
• Organism: Streptococcus zhangguiae strain zg-86
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1120465..1131859

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J5M87_RS05435 (J5M87_05435)	-	1120593..1121183 (-)	591	WP_154607989.1	class I SAM-dependent methyltransferase	-
J5M87_RS05440 (J5M87_05440)	coaA	1121281..1122201 (+)	921	WP_154607990.1	type I pantothenate kinase	-
J5M87_RS05445 (J5M87_05445)	rpsT	1122259..1122507 (+)	249	WP_012027069.1	30S ribosomal protein S20	-
J5M87_RS05450 (J5M87_05450)	-	1122566..1123075 (+)	510	WP_154607991.1	DNA topology modulation protein	-
J5M87_RS05455 (J5M87_05455)	-	1123106..1124872 (-)	1767	WP_154607992.1	flavocytochrome c	-
J5M87_RS05460 (J5M87_05460)	ciaH	1125465..1126859 (-)	1395	WP_154607993.1	cell wall metabolism sensor histidine kinase WalK	Regulator
J5M87_RS05465 (J5M87_05465)	ciaR	1126849..1127523 (-)	675	WP_154607994.1	response regulator transcription factor	Regulator
J5M87_RS05470 (J5M87_05470)	phoU	1127930..1128586 (-)	657	WP_154607995.1	phosphate signaling complex protein PhoU	-
J5M87_RS05475 (J5M87_05475)	pstB	1128605..1129363 (-)	759	WP_154607996.1	phosphate ABC transporter ATP-binding protein PstB	-
J5M87_RS05480 (J5M87_05480)	pstB	1129376..1130179 (-)	804	WP_154607997.1	phosphate ABC transporter ATP-binding protein PstB	-
J5M87_RS05485 (J5M87_05485)	pstA	1130195..1131082 (-)	888	WP_154632441.1	phosphate ABC transporter permease PstA	-

Sequence

Protein

• Length: 464 a.a.
• Molecular weight: 53314.39 Da
• Isoelectric Point: 8.3378

>NTDB_id=550540 J5M87_RS05460 WP_154607993.1 1125465..1126859(-) (ciaH) [Streptococcus zhangguiae strain zg-86]
MLIKFRKLYRTDNFSYFIRYFAVFTLIFSLMTIIIFQLMRSTMYQTSDENFREIVNNPEMMMEFARARGLSPEAEIIWEK
NTKATKNNSGNSQKEDEKEKSVSFYSSSKIRLNTNYHVILYDSRGNRLNQVDYFSGLSSLILSAKSLNTITECEVTTPFG
EKEYYRCMSIEVPEEAASAYVGLDIKYATVLFNTSQIRFSIASYEATVMIVMIGFWLISIVASIYLSNVSMRPILASFQK
QKEFVENASHELRTPLTVLQNRLESLFRHPEATIMDSSENIASSLAEVRNMRLLTTNLLNLARRDDGLKPEIIAVQPAFF
DEILANYIIMAEENGKILEVNHTVKEVIRTDKTLLKQLLTILVDNAIKYSEDDGHIWIDIQIKDRFLSIKVADNGLGISP
ENKTKIFDRFYRVDKARTRQKGGFGLGLSLAKQIIDTLHGTITVQDHQPKGTVFEVKIPKEYRK

Nucleotide

• Length: 1395 bp

>NTDB_id=550540 J5M87_RS05460 WP_154607993.1 1125465..1126859(-) (ciaH) [Streptococcus zhangguiae strain zg-86]
ATGCTGATTAAATTTCGCAAACTCTATCGTACGGATAATTTTTCTTATTTTATCCGTTATTTTGCTGTCTTTACGCTGAT
TTTCAGCCTGATGACAATCATTATTTTCCAGTTGATGCGTTCAACCATGTATCAGACTTCGGATGAGAATTTTAGAGAAA
TTGTGAATAATCCGGAAATGATGATGGAATTTGCACGGGCGCGCGGCTTGTCTCCAGAAGCAGAAATCATCTGGGAAAAA
AATACAAAGGCTACTAAAAATAATTCAGGGAATTCACAGAAAGAGGATGAGAAAGAGAAGTCTGTTTCCTTTTATTCCAG
TTCTAAAATTCGCCTGAATACGAATTACCATGTTATTCTCTATGATAGCCGTGGAAATCGTCTCAATCAAGTAGACTACT
TTTCTGGTTTATCTAGTCTTATCTTATCTGCTAAGTCACTGAATACCATTACAGAATGTGAAGTAACAACACCTTTTGGA
GAAAAAGAATACTATCGTTGTATGAGTATTGAAGTACCAGAAGAAGCTGCTTCAGCTTATGTGGGTCTAGATATCAAATA
TGCTACCGTTCTCTTTAATACCAGTCAGATTCGCTTCTCTATTGCATCGTATGAAGCGACGGTTATGATCGTCATGATTG
GCTTTTGGTTGATTTCGATTGTCGCAAGTATTTACCTGTCCAATGTCAGTATGCGCCCTATTCTTGCTAGTTTTCAAAAG
CAGAAAGAGTTTGTGGAGAATGCGAGTCATGAATTGCGAACACCGCTTACTGTCCTACAAAACCGTTTGGAAAGTCTTTT
TAGACATCCTGAAGCAACAATTATGGATAGCAGTGAAAATATTGCTTCTAGTCTTGCGGAGGTGCGCAATATGCGCCTTT
TAACAACGAATCTATTAAACCTAGCACGAAGAGATGATGGTTTGAAACCAGAAATTATTGCTGTTCAGCCAGCCTTCTTT
GATGAAATATTGGCAAATTATATCATCATGGCGGAAGAAAATGGAAAGATTTTGGAAGTCAATCATACCGTTAAGGAAGT
GATTCGTACAGATAAGACTCTGCTCAAGCAGTTACTGACGATTTTAGTTGATAATGCGATAAAGTATTCAGAAGATGATG
GACATATCTGGATTGATATTCAGATAAAAGATCGTTTTCTTTCTATTAAAGTAGCCGATAATGGATTGGGCATTAGTCCA
GAAAATAAAACAAAAATCTTTGATCGTTTCTACCGGGTTGATAAAGCGAGAACGCGTCAAAAAGGTGGATTCGGCCTCGG
TCTCTCTCTTGCGAAGCAAATCATTGATACCTTACATGGAACAATTACCGTTCAAGATCATCAGCCCAAAGGCACTGTTT
TTGAAGTTAAGATTCCTAAAGAATACCGTAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (241-307)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (351-461)

3D structure

• AlphaFold DB: A0A6I4RGI1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	50.218	98.707	0.496
ciaH	Streptococcus pneumoniae D39	50.218	98.707	0.496
ciaH	Streptococcus pneumoniae R6	50.218	98.707	0.496
ciaH	Streptococcus pneumoniae TIGR4	50.218	98.707	0.496
ciaH	Streptococcus mutans UA159	50	98.707	0.494