Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   J4Q31_RS03745 Genome accession   NZ_CP071918
Coordinates   707072..707662 (+) Length   196 a.a.
NCBI ID   WP_000613477.1    Uniprot ID   A0A064BX72
Organism   Streptococcus pneumoniae strain 19A-19343     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 692190..730047 707072..707662 within 0


Gene organization within MGE regions


Location: 692190..730047
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J4Q31_RS03660 (J4Q31_03640) - 692190..692585 (+) 396 WP_001167212.1 CopY/TcrY family copper transport repressor -
  J4Q31_RS03665 (J4Q31_03645) - 692596..692967 (+) 372 WP_000935063.1 cupredoxin domain-containing protein -
  J4Q31_RS03670 (J4Q31_03650) - 692977..695220 (+) 2244 WP_000136312.1 heavy metal translocating P-type ATPase -
  J4Q31_RS03675 (J4Q31_03655) spxB 695427..697202 (+) 1776 WP_000191798.1 pyruvate oxidase -
  J4Q31_RS03680 (J4Q31_03660) - 697313..697660 (+) 348 WP_001052655.1 VOC family protein -
  J4Q31_RS03685 (J4Q31_03665) - 697777..698823 (-) 1047 Protein_737 IS630 family transposase -
  J4Q31_RS03695 (J4Q31_03670) - 698864..699184 (+) 321 Protein_738 family 1 glycosylhydrolase -
  J4Q31_RS03700 (J4Q31_03675) manA 699305..700249 (+) 945 WP_001294322.1 mannose-6-phosphate isomerase, class I -
  J4Q31_RS03705 (J4Q31_03680) - 700270..701601 (-) 1332 WP_001814857.1 sodium-dependent transporter -
  J4Q31_RS03710 (J4Q31_03685) - 701684..702438 (+) 755 Protein_741 MerR family transcriptional regulator -
  J4Q31_RS03715 (J4Q31_03690) - 702458..702913 (-) 456 Protein_742 8-oxo-dGTP diphosphatase -
  J4Q31_RS03720 (J4Q31_03695) - 702933..704108 (-) 1176 WP_000680057.1 NAD(P)/FAD-dependent oxidoreductase -
  J4Q31_RS03725 (J4Q31_03700) - 704167..705012 (-) 846 WP_000219939.1 DegV family protein -
  J4Q31_RS03730 (J4Q31_03705) - 705137..705694 (+) 558 WP_000004139.1 TetR/AcrR family transcriptional regulator -
  J4Q31_RS03735 (J4Q31_03710) - 705713..706180 (+) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -
  J4Q31_RS03740 (J4Q31_03715) upp 706269..706898 (+) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  J4Q31_RS03745 (J4Q31_03720) clpP 707072..707662 (+) 591 WP_000613477.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  J4Q31_RS03750 (J4Q31_03725) - 707741..707989 (+) 249 WP_000462126.1 YlbG family protein -
  J4Q31_RS03755 (J4Q31_03730) - 708091..709251 (+) 1161 WP_000726146.1 ABC transporter substrate-binding protein -
  J4Q31_RS03760 (J4Q31_03735) - 709519..710388 (+) 870 WP_000941426.1 branched-chain amino acid ABC transporter permease -
  J4Q31_RS03765 (J4Q31_03740) - 710392..711348 (+) 957 WP_000662293.1 branched-chain amino acid ABC transporter permease -
  J4Q31_RS03770 (J4Q31_03745) - 711348..712112 (+) 765 WP_001186003.1 ABC transporter ATP-binding protein -
  J4Q31_RS03775 (J4Q31_03750) - 712112..712822 (+) 711 WP_000062221.1 ABC transporter ATP-binding protein -
  J4Q31_RS03780 (J4Q31_03755) - 713236..713892 (+) 657 WP_000268675.1 CBS domain-containing protein -
  J4Q31_RS03785 (J4Q31_03760) prfB 714000..715095 (+) 1096 WP_015511312.1 peptide chain release factor 2 -
  J4Q31_RS03790 (J4Q31_03765) ftsE 715113..715805 (+) 693 WP_000022264.1 cell division ATP-binding protein FtsE -
  J4Q31_RS03795 (J4Q31_03770) ftsX 715798..716724 (+) 927 WP_233923011.1 permease-like cell division protein FtsX -
  J4Q31_RS03800 (J4Q31_03775) - 717010..719190 (+) 2181 WP_000974064.1 PTS transporter subunit IIBC -
  J4Q31_RS03805 (J4Q31_03780) - 719242..720057 (+) 816 WP_000670830.1 endonuclease/exonuclease/phosphatase family protein -
  J4Q31_RS03810 (J4Q31_03785) - 720197..721540 (+) 1344 WP_000011009.1 DEAD/DEAH box helicase -
  J4Q31_RS03815 (J4Q31_03790) metK 721917..723107 (+) 1191 WP_000003934.1 methionine adenosyltransferase -
  J4Q31_RS03820 (J4Q31_03795) - 723660..724595 (+) 936 WP_000255160.1 dihydroorotate oxidase -
  J4Q31_RS03825 (J4Q31_03800) holA 724629..725666 (+) 1038 WP_000879655.1 DNA polymerase III subunit delta -
  J4Q31_RS03830 (J4Q31_03805) sodA 725807..726412 (+) 606 WP_000974746.1 superoxide dismutase SodA -
  J4Q31_RS03835 (J4Q31_03810) - 726569..727099 (+) 531 WP_001224352.1 YutD family protein -
  J4Q31_RS03840 (J4Q31_03815) rlmN 727120..728022 (+) 903 WP_000804645.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  J4Q31_RS03845 (J4Q31_03820) - 728022..728504 (+) 483 WP_000976707.1 VanZ family protein -
  J4Q31_RS03850 (J4Q31_03825) - 728506..730047 (+) 1542 WP_000025400.1 ABC-F family ATP-binding cassette domain-containing protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21358.36 Da        Isoelectric Point: 4.4910

>NTDB_id=549092 J4Q31_RS03745 WP_000613477.1 707072..707662(+) (clpP) [Streptococcus pneumoniae strain 19A-19343]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=549092 J4Q31_RS03745 WP_000613477.1 707072..707662(+) (clpP) [Streptococcus pneumoniae strain 19A-19343]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGGGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BX72

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

100

100

1
  clpP Streptococcus pneumoniae D39

100

100

1
  clpP Streptococcus pneumoniae R6

100

100

1
  clpP Streptococcus pneumoniae TIGR4

100

100

1
  clpP Streptococcus thermophilus LMG 18311

92.821

99.49

0.923
  clpP Streptococcus thermophilus LMD-9

92.821

99.49

0.923
  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903
  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903
  clpP Streptococcus mutans UA159

85.714

100

0.857
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847
  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842
  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571