NTDB

Overview

Name	micA	Type	Regulator
Locus tag	J1N58_RS07865	Genome accession	NZ_CP071697
Coordinates	1683271..1683975 (-)	Length	234 a.a.
NCBI ID	WP_004298854.1	Uniprot ID	A0A0K2E6P6
Organism	Streptococcus suis strain 1112S
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1678271..1688975

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J1N58_RS07850 (J1N58_07850)	vga(F)	1679203..1680588 (-)	1386	WP_207560251.1	ABC-F type ribosomal protection protein Vga(F)	-
J1N58_RS07855 (J1N58_07855)	vicX	1681119..1681922 (-)	804	WP_002935843.1	MBL fold metallo-hydrolase	Regulator
J1N58_RS07860 (J1N58_07860)	micB	1681929..1683278 (-)	1350	WP_029176482.1	cell wall metabolism sensor histidine kinase VicK	Regulator
J1N58_RS07865 (J1N58_07865)	micA	1683271..1683975 (-)	705	WP_004298854.1	response regulator YycF	Regulator
J1N58_RS07870 (J1N58_07870)	-	1684169..1684930 (+)	762	WP_002935839.1	amino acid ABC transporter ATP-binding protein	-
J1N58_RS07875 (J1N58_07875)	-	1684941..1685780 (+)	840	WP_099872401.1	transporter substrate-binding domain-containing protein	-
J1N58_RS07880 (J1N58_07880)	-	1685795..1686493 (+)	699	WP_004298848.1	amino acid ABC transporter permease	-
J1N58_RS07885 (J1N58_07885)	-	1686508..1687167 (+)	660	WP_099872398.1	amino acid ABC transporter permease	-
J1N58_RS11945 (J1N58_07890)	-	1687290..1687565 (+)	276	WP_061844941.1	acyltransferase family protein	-
J1N58_RS07895 (J1N58_07895)	-	1687537..1688331 (+)	795	WP_207560252.1	acyltransferase family protein	-

Sequence

Protein

Download Length: 234 a.a. Molecular weight: 26781.77 Da Isoelectric Point: 4.8957

                                >NTDB_id=547057 J1N58_RS07865 WP_004298854.1 1683271..1683975(-) (micA) [Streptococcus suis strain 1112S]

MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALEVFEAEFPDIVILDLMLPELDGLEVARTIRKTSNVPILMLSA

KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRSELAETQTNIESTGTPELVIGDLVILPDAFVAKKHGKELELT

HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGND

Nucleotide

Download Length: 705 bp

                                >NTDB_id=547057 J1N58_RS07865 WP_004298854.1 1683271..1683975(-) (micA) [Streptococcus suis strain 1112S]

ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCAGATATTATTAAGTTTAATATGACGCGTGAGGGATATGA

AGTTGTGACAGCTTTCGATGGACGTGAAGCCTTGGAAGTGTTTGAGGCTGAGTTTCCTGACATAGTCATTTTGGACTTGA

TGCTGCCAGAATTGGACGGACTAGAGGTTGCTCGAACGATTCGTAAGACCAGCAATGTTCCAATCTTGATGTTATCTGCT

AAAGATAGCGAATTTGATAAGGTTATCGGGCTTGAAATCGGGGCGGATGATTATGTGACCAAACCCTTCTCTAATCGCGA

ATTGCAGGCGCGTGTTAAGGCTCTTCTTCGTCGTAGTGAATTGGCAGAGACGCAGACAAATATTGAGTCAACAGGAACTC

CAGAGTTGGTGATTGGCGATTTGGTCATTCTGCCTGATGCGTTTGTCGCTAAGAAGCATGGTAAAGAGCTGGAGCTGACC

CATCGTGAGTTTGAATTGCTCCACCATCTGGCCAAACACTTAGGTCAGGTTATGACTCGAGAACATCTATTGGAAACAGT

TTGGGGTTATGATTACTTTGGTGATGTCCGCACGGTGGATGTAACGATTCGTCGTCTGCGTGAGAAAATTGAAGATACAC

CAAGCCGACCAGAATACATTCTTACTCGTCGCGGAGTGGGATATTTTATAAAAGGAAATGATTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A0K2E6P6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	81.974	99.573	0.816
vicR	Streptococcus mutans UA159	80.426	100	0.808
covR	Lactococcus lactis subsp. lactis strain DGCC12653	44.783	98.291	0.44
covR	Streptococcus salivarius strain HSISS4	43.723	98.718	0.432
scnR	Streptococcus mutans UA159	38.095	98.718	0.376

Detailed information NTG0547057