Detailed information NTG0547045

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: J1N58_RS04815
• Genome accession: NZ_CP071697
• Coordinates: 994697..995368 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain 1112S
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 989697..1000368

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
J1N58_RS04785 (J1N58_04785)	pstC	989944..990861 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
J1N58_RS04790 (J1N58_04790)	pstA	990851..991738 (+)	888	WP_044757644.1	phosphate ABC transporter permease PstA	-
J1N58_RS04795 (J1N58_04795)	pstB	991763..992566 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
J1N58_RS04800 (J1N58_04800)	pstB	992578..993336 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
J1N58_RS04805 (J1N58_04805)	phoU	993365..994021 (+)	657	WP_002940865.1	phosphate signaling complex protein PhoU	-
J1N58_RS04810 (J1N58_04810)	-	994171..994551 (+)	381	WP_105147512.1	hypothetical protein	-
J1N58_RS04815 (J1N58_04815)	ciaR	994697..995368 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
J1N58_RS04820 (J1N58_04820)	ciaH	995361..996740 (+)	1380	WP_207560579.1	HAMP domain-containing sensor histidine kinase	Regulator
J1N58_RS04825 (J1N58_04825)	-	996841..998070 (+)	1230	WP_024376493.1	transglutaminase domain-containing protein	-
J1N58_RS04830 (J1N58_04830)	rpsT	998334..998582 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
J1N58_RS04835 (J1N58_04835)	coaA	998641..999561 (-)	921	WP_002935283.1	type I pantothenate kinase	-
J1N58_RS04840 (J1N58_04840)	-	999670..1000260 (+)	591	WP_207560580.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=547045 J1N58_RS04815 WP_014637852.1 994697..995368(+) (ciaR) [Streptococcus suis strain 1112S]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=547045 J1N58_RS04815 WP_014637852.1 994697..995368(+) (ciaR) [Streptococcus suis strain 1112S]
ATGATTAAGATTTTGTTAGTAGAAGACGATTTAAGCCTATCCAATTCAGTTTTTGACTTCCTAGATGATTTTGCAGATGT
CATGCAAGTTTTTGATGGAGAAGAAGGAATCTATGAAGCGGAAACTGGTGTGTACGACTTAATTTTATTAGATTTAATGT
TACCTGAAAAAGACGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACGGCC
AAGGAAAGTCTTGAGGATAAAGGTCATGGATTTGAATTAGGTGCAGATGATTATTTGACCAAGCCATTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACGCTAACTTATGGAGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368