Detailed information NTG0544863

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: JZY07_RS04400
• Genome accession: NZ_CP071305
• Coordinates: 872276..872947 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain SC183
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 867276..877947

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JZY07_RS04370 (JZY07_04370)	pstC	867492..868409 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
JZY07_RS04375 (JZY07_04375)	pstA	868399..869286 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
JZY07_RS04380 (JZY07_04380)	pstB	869311..870114 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
JZY07_RS04385 (JZY07_04385)	pstB	870126..870884 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
JZY07_RS04390 (JZY07_04390)	phoU	870913..871569 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
JZY07_RS04395 (JZY07_04395)	-	871735..872082 (+)	348	WP_014635995.1	hypothetical protein	-
JZY07_RS04400 (JZY07_04400)	ciaR	872276..872947 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
JZY07_RS04405 (JZY07_04405)	ciaH	872940..874319 (+)	1380	WP_105155592.1	HAMP domain-containing sensor histidine kinase	Regulator
JZY07_RS11580	-	874420..875139 (+)	720	WP_242513108.1	transglutaminase domain-containing protein	-
JZY07_RS11585	-	875102..875650 (+)	549	WP_242513109.1	hypothetical protein	-
JZY07_RS04415 (JZY07_04415)	rpsT	875866..876114 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
JZY07_RS04420 (JZY07_04420)	coaA	876173..877093 (-)	921	WP_002935283.1	type I pantothenate kinase	-
JZY07_RS04425 (JZY07_04425)	-	877202..877792 (+)	591	WP_024376492.1	class I SAM-dependent methyltransferase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=544863 JZY07_RS04400 WP_014637852.1 872276..872947(+) (ciaR) [Streptococcus suis strain SC183]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=544863 JZY07_RS04400 WP_014637852.1 872276..872947(+) (ciaR) [Streptococcus suis strain SC183]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGACGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTCTTGCAAAATCAAAATGTTATCTTACCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368