Detailed information NTG0541900

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JX573_RS09445
• Genome accession: NZ_CP070983
• Coordinates: 1932517..1933560 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain WBG8366
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1927517..1938560

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JX573_RS09415 (JX573_09410)	-	1927939..1929195 (-)	1257	WP_072398252.1	aminopeptidase	-
JX573_RS09420 (JX573_09415)	-	1929198..1929398 (-)	201	WP_000180460.1	DUF1128 family protein	-
JX573_RS09425 (JX573_09420)	-	1929545..1930009 (+)	465	WP_000567539.1	low molecular weight protein-tyrosine-phosphatase	-
JX573_RS09430 (JX573_09425)	-	1930016..1930291 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
JX573_RS09435 (JX573_09430)	-	1930569..1931786 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
JX573_RS09440 (JX573_09435)	vraR	1931898..1932527 (-)	630	WP_000153532.1	two-component system response regulator VraR	Regulator
JX573_RS09445 (JX573_09440)	vraS	1932517..1933560 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JX573_RS09450 (JX573_09445)	liaF	1933557..1934258 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
JX573_RS09455 (JX573_09450)	-	1934273..1934659 (-)	387	WP_001110179.1	hypothetical protein	-
JX573_RS09460 (JX573_09455)	map	1934876..1935634 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
JX573_RS09465 (JX573_09460)	-	1936106..1937092 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
JX573_RS09470 (JX573_09465)	-	1937523..1937936 (-)	414	WP_025175030.1	hypothetical protein	-
JX573_RS09475 (JX573_09470)	-	1937965..1938075 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=541900 JX573_RS09445 WP_001017131.1 1932517..1933560(-) (vraS) [Staphylococcus aureus strain WBG8366]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=541900 JX573_RS09445 WP_001017131.1 1932517..1933560(-) (vraS) [Staphylococcus aureus strain WBG8366]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTAATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGTTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1