Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6K87_RS07505 Genome accession   NZ_CP069892
Coordinates   1524098..1525288 (-) Length   396 a.a.
NCBI ID   WP_003029517.1    Uniprot ID   A0AAI9J965
Organism   Streptococcus anginosus strain FDAARGOS_1357     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1519098..1530288
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6K87_RS07480 (I6K87_07480) - 1519691..1520191 (+) 501 WP_204982518.1 YehR family lipoprotein -
  I6K87_RS07485 (I6K87_07485) - 1520215..1520412 (-) 198 WP_022526716.1 DUF951 domain-containing protein -
  I6K87_RS07490 (I6K87_07490) dnaN 1520412..1521548 (-) 1137 WP_059221678.1 DNA polymerase III subunit beta -
  I6K87_RS07495 (I6K87_07495) dnaA 1521705..1523048 (-) 1344 WP_003029515.1 chromosomal replication initiator protein DnaA -
  I6K87_RS07500 (I6K87_07500) spo0J 1523276..1524043 (-) 768 WP_059221676.1 ParB/RepB/Spo0J family partition protein Regulator
  I6K87_RS07505 (I6K87_07505) htrA 1524098..1525288 (-) 1191 WP_003029517.1 S1C family serine protease Regulator
  I6K87_RS07510 (I6K87_07510) rlmH 1525481..1525960 (+) 480 WP_049533214.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6K87_RS07520 (I6K87_07520) - 1526242..1526388 (+) 147 WP_003029519.1 bacteriocin -
  I6K87_RS07525 (I6K87_07525) comD/comD2 1526409..1527731 (+) 1323 WP_218969867.1 sensor histidine kinase Regulator
  I6K87_RS07530 (I6K87_07530) comE 1527731..1528480 (+) 750 WP_049517113.1 competence system response regulator transcription factor ComE Regulator

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41678.63 Da        Isoelectric Point: 9.4264

>NTDB_id=537275 I6K87_RS07505 WP_003029517.1 1524098..1525288(-) (htrA) [Streptococcus anginosus strain FDAARGOS_1357]
MKNSSNFTKKLLLLFMVLAIGFIGGLLGNLTSSKLSTNSSTTTKVNQVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNNNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVISGAKKVDIRLADGNKVPGEIVGSDTYSDISVVRIS
ADKVKSVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSEDGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIANNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSSSDLSRLKLPSKITSGV
VVRSAQSGMPAEGKLQKYDVITKVDDKEISSTSDLQSALYKHSIGDNIKITFYRDGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=537275 I6K87_RS07505 WP_003029517.1 1524098..1525288(-) (htrA) [Streptococcus anginosus strain FDAARGOS_1357]
ATGAAAAACTCTTCAAATTTCACAAAAAAATTGTTATTGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTACT
TGGAAACTTAACTTCATCTAAATTATCAACAAATAGCTCTACAACGACTAAAGTTAATCAAGTTACTACTGCTTATAAAA
ATACAAATTCCACAACACAAGCTGTGAGTAAAGTAAAAGATGCTGTTGTATCCGTTATTACCTATGCTAATAATAATTCA
CAAAACAGTGTGTTTGGAAATGATGATTCAAATAATAACAATGATAATTCTCAACAAGTAGCTAGCGAAGGATCTGGAGT
TATTTATAAAAAAGATGGAAAATACGCTTACTTAGTAACCAATACCCACGTTATCAGTGGTGCTAAAAAAGTTGACATTC
GTTTAGCAGATGGTAATAAAGTTCCTGGAGAAATTGTAGGGTCAGATACTTATTCTGATATCTCCGTTGTTCGCATCAGT
GCTGATAAAGTAAAATCAGTTGCTGAATTTGGAGATTCTAGCAAATTGACTGTTGGTGAGACAGCTATTGCAATTGGAAG
TCCACTTGGTTCAAATTATGCTAATACTGTGACTCAAGGAATTATTTCTAGTTTAAATCGTAATGTTTCTCTAAAATCTG
AAGACGGACAAACGATTTCAACACAAGCTATTCAAACAGACACAGCTATCAACCCAGGGAACTCTGGTGGACCACTTGTG
AATATCCAAGGGCAAGTAATTGGTATTACTTCAAGTAAAATAGCTAACAACGGCGGAACTTCGGTTGAAGGATTAGGATT
TGCTATTCCATCTAATGATGTTATAAACATTATTAACCAGTTAGAAGCAAATGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATTGACATCACTAATCTGTCTAGTTCAGATCTATCACGTTTAAAACTCCCATCAAAAATAACTAGTGGAGTT
GTCGTACGTTCAGCTCAATCTGGAATGCCAGCTGAAGGAAAACTTCAAAAATATGATGTGATTACAAAAGTAGATGATAA
AGAAATTTCTTCAACAAGTGATTTACAATCCGCTTTATACAAACATTCAATTGGTGACAACATAAAAATCACTTTCTATC
GTGATGGAAAAGAAACTACTACTACCATTAAGCTTACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(265-390)

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

75.81

100

0.768
  htrA Streptococcus mitis NCTC 12261

72.544

100

0.727
  htrA Streptococcus pneumoniae Rx1

72.292

100

0.725
  htrA Streptococcus pneumoniae D39

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.292

100

0.725
  htrA Streptococcus pneumoniae TIGR4

72.292

100

0.725
  htrA Streptococcus mutans UA159

55.216

99.242

0.548