Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   I6K87_RS02330 Genome accession   NZ_CP069892
Coordinates   473258..473932 (+) Length   224 a.a.
NCBI ID   WP_003024352.1    Uniprot ID   A0AAI9NIE3
Organism   Streptococcus anginosus strain FDAARGOS_1357     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 468258..478932
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6K87_RS09885 - 469038..469433 (-) 396 WP_003027902.1 helix-turn-helix domain-containing protein -
  I6K87_RS02305 (I6K87_02305) - 469749..470708 (+) 960 WP_003027901.1 ROK family glucokinase -
  I6K87_RS02310 (I6K87_02310) rplS 470858..471205 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  I6K87_RS02320 (I6K87_02320) - 471447..472145 (+) 699 WP_204982715.1 alpha/beta fold hydrolase -
  I6K87_RS02325 (I6K87_02325) - 472531..472986 (+) 456 WP_049507117.1 hypothetical protein -
  I6K87_RS02330 (I6K87_02330) ciaR 473258..473932 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  I6K87_RS02335 (I6K87_02335) ciaH 473922..475268 (+) 1347 WP_059220781.1 sensor histidine kinase Regulator
  I6K87_RS02340 (I6K87_02340) - 475655..477103 (-) 1449 WP_106079252.1 alpha-amylase -
  I6K87_RS02345 (I6K87_02345) - 477280..478893 (+) 1614 WP_049533160.1 M20/M25/M40 family metallo-hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25359.01 Da        Isoelectric Point: 4.2408

>NTDB_id=537229 I6K87_RS02330 WP_003024352.1 473258..473932(+) (ciaR) [Streptococcus anginosus strain FDAARGOS_1357]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLIMTA
KESLNDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDVTVNLSTNTTLVDGNEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFANNLQTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=537229 I6K87_RS02330 WP_003024352.1 473258..473932(+) (ciaR) [Streptococcus anginosus strain FDAARGOS_1357]
ATGATTAAGATTCTATTAGTGGAAGACGACCTCGGTCTATCTAATTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAAGTTTTTGACGGTGAGGAAGGATTGTACGAGGCTGAGAGTGGCGTGTACGACCTTATATTGCTTGATTTGATGT
TGCCAGAAAAAGACGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAAGGTGTCACAACTCCTGTGCTAATCATGACAGCC
AAAGAAAGTTTGAATGATAAAGGACATGGTTTTGAACTGGGTGCTGATGATTATTTGACCAAGCCATTTTATCTAGAAGA
GTTAAAAATGCGGATTCAAGCTCTGTTGAAGCGTTCTGGCAAGTTCAATGAAAACACCCTTTCTTATGGCGATGTCACTG
TTAATTTATCAACTAACACAACACTTGTAGACGGAAATGAAGTAGAATTGCTCGGAAAAGAATTTGACTTGCTGGTGTAT
TTCTTGCAAAATCAAAATGTCATTTTGCCTAAGACACAGATTTTCGATCGCTTGTGGGGATTTGATAGTGATACAACGAT
TTCAGTCGTAGAAGTCTATGTTTCAAAAATCCGGAAAAAATTGAAAGGGACGACCTTTGCGAACAATCTTCAAACGCTTC
GCAGCGTCGGATATATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

91.964

100

0.92
  ciaR Streptococcus pneumoniae D39

91.964

100

0.92
  ciaR Streptococcus pneumoniae R6

91.964

100

0.92
  ciaR Streptococcus pneumoniae TIGR4

91.964

100

0.92
  ciaR Streptococcus mutans UA159

90.135

99.554

0.897
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.767

100

0.393
  vicR Streptococcus mutans UA159

36.052

100

0.375
  covR Streptococcus salivarius strain HSISS4

35.683

100

0.362