Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   I6K87_RS02335 Genome accession   NZ_CP069892
Coordinates   473922..475268 (+) Length   448 a.a.
NCBI ID   WP_059220781.1    Uniprot ID   -
Organism   Streptococcus anginosus strain FDAARGOS_1357     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 468922..480268
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6K87_RS09885 - 469038..469433 (-) 396 WP_003027902.1 helix-turn-helix domain-containing protein -
  I6K87_RS02305 (I6K87_02305) - 469749..470708 (+) 960 WP_003027901.1 ROK family glucokinase -
  I6K87_RS02310 (I6K87_02310) rplS 470858..471205 (+) 348 WP_003024326.1 50S ribosomal protein L19 -
  I6K87_RS02320 (I6K87_02320) - 471447..472145 (+) 699 WP_204982715.1 alpha/beta fold hydrolase -
  I6K87_RS02325 (I6K87_02325) - 472531..472986 (+) 456 WP_049507117.1 hypothetical protein -
  I6K87_RS02330 (I6K87_02330) ciaR 473258..473932 (+) 675 WP_003024352.1 response regulator transcription factor Regulator
  I6K87_RS02335 (I6K87_02335) ciaH 473922..475268 (+) 1347 WP_059220781.1 sensor histidine kinase Regulator
  I6K87_RS02340 (I6K87_02340) - 475655..477103 (-) 1449 WP_106079252.1 alpha-amylase -
  I6K87_RS02345 (I6K87_02345) - 477280..478893 (+) 1614 WP_049533160.1 M20/M25/M40 family metallo-hydrolase -
  I6K87_RS02350 (I6K87_02350) - 478941..479450 (-) 510 WP_049533159.1 DNA topology modulation protein -
  I6K87_RS02355 (I6K87_02355) rpsT 479514..479765 (-) 252 WP_020999623.1 30S ribosomal protein S20 -

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 50941.67 Da        Isoelectric Point: 10.1292

>NTDB_id=537230 I6K87_RS02335 WP_059220781.1 473922..475268(+) (ciaH) [Streptococcus anginosus strain FDAARGOS_1357]
MLNKLKKTWYADDFSYFIRNFGIFTLIFSAMTLIIIQVMRSSLYTTVDNNLKSLSQDSASVINLALARRVGLEQKSDNGE
PKADTGDKELTDKPNVSANTEVILFDKDYKPIITSNNFLGLNKLSFNSKQLDRIRQVQVKSNYGREETYRTILFKVKLPN
LETNVKYAAVFINISQLEQTSQNHEHLIVVVMISFWGISLIASVYLARVSVKPLLESIQKQKSFVENASHELRTPLAVLQ
NRLETLFRKPEATIMESSESIASSLDEVRNMKMLTTNLLNLARRDDGIKPEIGDVEPNFFNTTFTNYEMVAAENGKTFRF
DNRIHRMIKTDKTLLKQLMTILFDNALKYTDEDGVIELTISANDRTLFLKVADNGPGISTADKKKIFDRFYRVDKARTRQ
TGGFGLGLSLAKQITEALKGTITVKDNKPKGTIFEVKIAIRTDNRKKK

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=537230 I6K87_RS02335 WP_059220781.1 473922..475268(+) (ciaH) [Streptococcus anginosus strain FDAARGOS_1357]
ATGCTGAATAAACTAAAAAAAACATGGTATGCGGATGATTTTTCTTATTTCATTCGCAATTTTGGTATTTTTACTCTCAT
TTTCTCAGCCATGACTCTGATTATCATTCAGGTGATGCGCTCAAGCCTTTATACAACGGTCGATAATAACTTGAAAAGTC
TCAGTCAGGATTCCGCTTCTGTCATCAATTTGGCGCTCGCTCGGAGAGTGGGGCTGGAACAGAAGTCAGACAACGGAGAG
CCTAAAGCCGATACGGGTGACAAAGAGCTTACTGATAAACCAAATGTCAGTGCCAATACGGAAGTTATCTTATTTGATAA
GGATTACAAGCCGATTATTACTAGCAATAATTTTCTGGGACTTAACAAACTTTCCTTTAATAGCAAGCAATTGGATCGCA
TTCGGCAAGTTCAAGTAAAAAGCAATTATGGGCGTGAAGAAACCTATCGGACGATTTTATTTAAGGTGAAATTGCCTAAT
TTGGAAACGAACGTTAAATACGCAGCTGTCTTTATCAATATCAGCCAATTGGAACAAACCAGTCAAAATCATGAGCATCT
AATAGTCGTGGTAATGATTAGTTTCTGGGGAATTTCTTTGATTGCAAGTGTCTATCTGGCTCGGGTTAGTGTTAAACCTT
TGTTGGAGAGTATTCAAAAGCAAAAGAGCTTTGTTGAAAATGCTAGCCACGAGTTGCGCACACCTCTAGCAGTTTTGCAA
AATCGCTTGGAAACCTTGTTTAGAAAACCAGAAGCCACCATTATGGAATCAAGCGAAAGCATTGCTTCTAGTTTGGATGA
AGTGCGAAACATGAAAATGTTGACGACAAATCTACTCAATCTAGCACGACGCGATGACGGGATTAAACCAGAAATTGGCG
ATGTCGAGCCAAATTTCTTTAATACGACCTTTACCAACTATGAGATGGTTGCCGCAGAAAATGGGAAAACTTTCCGATTT
GACAATAGGATTCACCGCATGATTAAAACAGACAAGACCTTGCTGAAGCAATTGATGACAATTCTGTTTGATAATGCCTT
GAAATATACAGATGAAGACGGTGTAATTGAGTTGACGATTTCAGCGAATGACCGGACCCTTTTTTTGAAAGTTGCAGATA
ATGGTCCGGGGATTAGTACGGCAGATAAGAAAAAGATTTTTGATCGTTTTTATCGTGTTGATAAAGCACGGACTCGGCAG
ACAGGCGGTTTTGGTCTAGGCTTGTCGCTTGCAAAGCAAATCACAGAAGCCCTTAAAGGGACTATTACGGTGAAAGATAA
TAAGCCGAAAGGAACCATTTTTGAGGTGAAGATTGCCATTAGAACGGACAATAGAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(331-438)

His Kinase A (phospho-acceptor) domain (HisKA)

(222-287)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

70.982

100

0.71
  ciaH Streptococcus pneumoniae D39

70.982

100

0.71
  ciaH Streptococcus pneumoniae R6

70.982

100

0.71
  ciaH Streptococcus pneumoniae TIGR4

70.982

100

0.71
  ciaH Streptococcus mutans UA159

56.591

98.214

0.556