Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   I6J38_RS07255 Genome accession   NZ_CP069558
Coordinates   1453465..1454655 (+) Length   396 a.a.
NCBI ID   WP_006270334.1    Uniprot ID   U2XXY1
Organism   Streptococcus constellatus strain FDAARGOS_1208     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1448465..1459655
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J38_RS07230 (I6J38_07230) comE 1450270..1451019 (-) 750 WP_003071650.1 competence system response regulator transcription factor ComE Regulator
  I6J38_RS07235 (I6J38_07235) comD/comD1 1451019..1452332 (-) 1314 WP_020998131.1 GHKL domain-containing protein Regulator
  I6J38_RS07240 (I6J38_07240) - 1452352..1452498 (-) 147 WP_006268843.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  I6J38_RS07250 (I6J38_07250) rlmH 1452781..1453260 (-) 480 WP_006268880.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  I6J38_RS07255 (I6J38_07255) htrA 1453465..1454655 (+) 1191 WP_006270334.1 S1C family serine protease Regulator
  I6J38_RS07260 (I6J38_07260) spo0J 1454710..1455477 (+) 768 WP_003071657.1 ParB/RepB/Spo0J family partition protein Regulator
  I6J38_RS07265 (I6J38_07265) dnaA 1455706..1457049 (+) 1344 WP_020997506.1 chromosomal replication initiator protein DnaA -
  I6J38_RS07270 (I6J38_07270) dnaN 1457206..1458342 (+) 1137 WP_006268813.1 DNA polymerase III subunit beta -
  I6J38_RS07275 (I6J38_07275) - 1458342..1458539 (+) 198 WP_003071662.1 DUF951 domain-containing protein -
  I6J38_RS07280 (I6J38_07280) - 1458626..1459126 (-) 501 WP_006268820.1 YehR family lipoprotein -

Sequence

Protein


Download         Length: 396 a.a.        Molecular weight: 41637.72 Da        Isoelectric Point: 9.8633

>NTDB_id=535547 I6J38_RS07255 WP_006270334.1 1453465..1454655(+) (htrA) [Streptococcus constellatus strain FDAARGOS_1208]
MKNSSNFTKKLLWLFMVLAIGFIGGLFGNLTSSKLSTNSSTTTKVNKVTTAYKNTNSTTQAVSKVKDAVVSVITYANNNS
QNSVFGNDDSNTNNDNSQQVASEGSGVIYKKDGKYAYLVTNTHVINGAKKVDIRLADGNKVPGEIIGSDTYSDISVVRIS
ADKVKTVAEFGDSSKLTVGETAIAIGSPLGSNYANTVTQGIISSLNRNVSLKSESGQTISTQAIQTDTAINPGNSGGPLV
NIQGQVIGITSSKIASNGGTSVEGLGFAIPSNDVINIINQLEANGTVTRPALGIQMIDITNLSNSDLSRLKLPSKVTSGV
VVRSAQAGMPAAGKLQKYDVITKVDGKDISSVSDLQSALYKHSIGDDIKITFYRNGKETTTTIKLTKSTKDLDSNN

Nucleotide


Download         Length: 1191 bp        

>NTDB_id=535547 I6J38_RS07255 WP_006270334.1 1453465..1454655(+) (htrA) [Streptococcus constellatus strain FDAARGOS_1208]
ATGAAAAATTCTTCAAATTTTACAAAAAAATTATTATGGCTTTTCATGGTCTTAGCTATAGGTTTTATTGGTGGTTTATT
TGGAAACTTAACCTCATCAAAATTATCAACAAATAGTTCTACAACAACTAAGGTTAACAAAGTTACTACTGCTTATAAAA
ATACAAATTCTACAACACAAGCTGTAAGCAAAGTAAAGGATGCAGTTGTATCTGTTATTACCTATGCTAATAATAATTCT
CAAAATAGTGTTTTTGGAAATGATGATTCAAATACTAATAACGATAATTCTCAACAAGTAGCTAGTGAAGGATCTGGGGT
TATTTATAAAAAAGACGGAAAATACGCCTACTTAGTGACCAATACCCATGTTATTAATGGTGCTAAAAAAGTTGATATTC
GTTTGGCTGATGGGAATAAAGTTCCTGGAGAAATTATAGGTTCAGATACTTATTCTGATATCTCTGTTGTTCGTATTAGT
GCTGATAAAGTAAAAACAGTTGCTGAATTTGGAGATTCTAGTAAATTAACTGTTGGTGAAACAGCTATTGCGATTGGAAG
TCCACTCGGATCAAATTATGCTAATACTGTGACACAAGGAATTATTTCTAGCTTAAATCGTAATGTGTCTTTAAAATCTG
AAAGCGGTCAAACTATTTCAACACAAGCTATCCAAACTGATACAGCTATCAATCCAGGGAATTCTGGTGGTCCACTTGTA
AATATCCAAGGACAAGTAATTGGTATTACTTCAAGTAAAATTGCTAGCAACGGTGGAACTTCTGTTGAGGGATTAGGTTT
TGCCATTCCATCTAATGATGTTATTAATATTATCAATCAATTAGAAGCAAACGGAACTGTTACACGACCAGCTCTAGGAA
TCCAAATGATCGACATCACTAATCTGTCTAATTCAGATTTATCACGCTTAAAACTCCCATCCAAAGTAACTAGTGGGGTT
GTTGTACGTTCAGCTCAAGCTGGGATGCCTGCAGCAGGAAAGCTTCAAAAATATGATGTTATTACAAAAGTAGATGGCAA
AGACATTTCCTCAGTAAGTGATTTACAATCTGCTTTATACAAACATTCAATTGGTGATGATATAAAAATTACATTTTATC
GTAATGGAAAAGAAACAACAACTACTATTAAGCTGACAAAATCTACAAAAGATTTAGATTCAAATAATTGA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(290-385)

Peptidase family M50 (Peptidase_M50)

(266-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB U2XXY1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

74.25

100

0.75
  htrA Streptococcus mitis NCTC 12261

72.292

100

0.725
  htrA Streptococcus pneumoniae R6

72.04

100

0.722
  htrA Streptococcus pneumoniae TIGR4

72.04

100

0.722
  htrA Streptococcus pneumoniae D39

72.04

100

0.722
  htrA Streptococcus pneumoniae Rx1

72.04

100

0.722
  htrA Streptococcus mutans UA159

55.838

99.495

0.556