Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   HMPREF1038_RS03735 Genome accession   NC_018630
Coordinates   696386..696976 (+) Length   196 a.a.
NCBI ID   WP_000613476.1    Uniprot ID   C1CJJ5
Organism   Streptococcus pneumoniae gamPNI0373     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 695027..705931 696386..696976 within 0


Gene organization within MGE regions


Location: 695027..705931
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HMPREF1038_RS03725 (HMPREF1038_00757) - 695027..695494 (+) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -
  HMPREF1038_RS03730 (HMPREF1038_00758) upp 695583..696212 (+) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  HMPREF1038_RS03735 (HMPREF1038_00759) clpP 696386..696976 (+) 591 WP_000613476.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  HMPREF1038_RS03740 (HMPREF1038_00760) - 697055..697303 (+) 249 WP_000462126.1 YlbG family protein -
  HMPREF1038_RS03745 (HMPREF1038_00761) - 697404..698564 (+) 1161 WP_000726147.1 ABC transporter substrate-binding protein -
  HMPREF1038_RS03750 (HMPREF1038_00762) - 698832..699701 (+) 870 WP_000941426.1 branched-chain amino acid ABC transporter permease -
  HMPREF1038_RS03755 (HMPREF1038_00763) - 699705..700661 (+) 957 WP_000662293.1 branched-chain amino acid ABC transporter permease -
  HMPREF1038_RS03760 (HMPREF1038_00764) - 700661..701425 (+) 765 WP_001186003.1 ABC transporter ATP-binding protein -
  HMPREF1038_RS03765 (HMPREF1038_00765) - 701425..702135 (+) 711 WP_000062219.1 ABC transporter ATP-binding protein -
  HMPREF1038_RS03770 (HMPREF1038_00766) - 702443..703099 (+) 657 WP_000268677.1 CBS domain-containing protein -
  HMPREF1038_RS03775 (HMPREF1038_00767) prfB 703207..704302 (+) 1096 WP_010963246.1 peptide chain release factor 2 -
  HMPREF1038_RS03780 (HMPREF1038_00768) ftsE 704320..705012 (+) 693 WP_000022268.1 cell division ATP-binding protein FtsE -
  HMPREF1038_RS03785 (HMPREF1038_00769) ftsX 705005..705931 (+) 927 WP_000625536.1 permease-like cell division protein FtsX -

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21367.37 Da        Isoelectric Point: 4.5912

>NTDB_id=53335 HMPREF1038_RS03735 WP_000613476.1 696386..696976(+) (clpP) [Streptococcus pneumoniae gamPNI0373]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAHETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=53335 HMPREF1038_RS03735 WP_000613476.1 696386..696976(+) (clpP) [Streptococcus pneumoniae gamPNI0373]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACAAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGAGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCATGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB C1CJJ5

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

99.49

100

0.995

  clpP Streptococcus pneumoniae D39

99.49

100

0.995

  clpP Streptococcus pneumoniae R6

99.49

100

0.995

  clpP Streptococcus pneumoniae TIGR4

99.49

100

0.995

  clpP Streptococcus thermophilus LMG 18311

92.308

99.49

0.918

  clpP Streptococcus thermophilus LMD-9

92.308

99.49

0.918

  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903

  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903

  clpP Streptococcus mutans UA159

85.714

100

0.857

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847

  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842

  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

57.513

98.469

0.566


Multiple sequence alignment