Detailed information
Bioinformatically predicted
Overview
| Name | prx | Type | Regulator |
| Locus tag | JHX98_RS00495 | Genome accession | NZ_CP067010 |
| Coordinates | 73860..74042 (+) | Length | 60 a.a. |
| NCBI ID | WP_011054856.1 | Uniprot ID | - |
| Organism | Streptococcus pyogenes strain iGAS376 | ||
| Function | Inhibit ComR activation (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12574..86602 | 73860..74042 | within | 0 |
Gene organization within MGE regions
Location: 12574..86602
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JHX98_RS00060 (JHX98_00060) | ftsH | 12574..14553 (+) | 1980 | WP_002981901.1 | ATP-dependent zinc metalloprotease FtsH | - |
| JHX98_RS00065 (JHX98_00065) | - | 14879..16270 (+) | 1392 | WP_011888516.1 | amino acid permease | - |
| JHX98_RS00240 (JHX98_00240) | - | 30826..32022 (+) | 1197 | WP_011017226.1 | CHAP domain-containing protein | - |
| JHX98_RS00245 (JHX98_00245) | - | 32275..33237 (+) | 963 | WP_002986722.1 | ribose-phosphate diphosphokinase | - |
| JHX98_RS00250 (JHX98_00250) | recO | 33423..34178 (+) | 756 | WP_002986719.1 | DNA repair protein RecO | - |
| JHX98_RS00255 (JHX98_00255) | - | 34310..35398 (-) | 1089 | WP_200221150.1 | site-specific integrase | - |
| JHX98_RS00260 (JHX98_00260) | - | 35574..36125 (-) | 552 | WP_011054899.1 | hypothetical protein | - |
| JHX98_RS00265 (JHX98_00265) | - | 36136..36519 (-) | 384 | WP_011054898.1 | ImmA/IrrE family metallo-endopeptidase | - |
| JHX98_RS00270 (JHX98_00270) | - | 36533..36883 (-) | 351 | WP_011184049.1 | helix-turn-helix transcriptional regulator | - |
| JHX98_RS00275 (JHX98_00275) | - | 37522..37713 (+) | 192 | WP_001283052.1 | hypothetical protein | - |
| JHX98_RS00280 (JHX98_00280) | - | 37764..37964 (+) | 201 | WP_011184050.1 | hypothetical protein | - |
| JHX98_RS00285 (JHX98_00285) | - | 38052..38309 (+) | 258 | WP_011054895.1 | hypothetical protein | - |
| JHX98_RS00290 (JHX98_00290) | - | 38338..38508 (+) | 171 | WP_011054894.1 | hypothetical protein | - |
| JHX98_RS00295 (JHX98_00295) | - | 38501..38708 (+) | 208 | Protein_25 | hypothetical protein | - |
| JHX98_RS00300 (JHX98_00300) | - | 38705..39088 (+) | 384 | WP_011054892.1 | hypothetical protein | - |
| JHX98_RS00305 (JHX98_00305) | - | 39233..39436 (+) | 204 | WP_011054890.1 | hypothetical protein | - |
| JHX98_RS00310 (JHX98_00310) | - | 39524..39823 (+) | 300 | WP_000573833.1 | hypothetical protein | - |
| JHX98_RS00315 (JHX98_00315) | - | 39823..40980 (+) | 1158 | WP_011054889.1 | DUF2800 domain-containing protein | - |
| JHX98_RS00320 (JHX98_00320) | - | 40994..41557 (+) | 564 | WP_011054888.1 | DUF2815 family protein | - |
| JHX98_RS00325 (JHX98_00325) | - | 41600..43522 (+) | 1923 | WP_011054887.1 | DNA polymerase | - |
| JHX98_RS00330 (JHX98_00330) | - | 43527..45911 (+) | 2385 | WP_011054886.1 | phage/plasmid primase, P4 family | - |
| JHX98_RS00335 (JHX98_00335) | - | 46277..46552 (+) | 276 | WP_011054885.1 | VRR-NUC domain-containing protein | - |
| JHX98_RS00340 (JHX98_00340) | - | 46549..47871 (+) | 1323 | WP_011054884.1 | SNF2-related protein | - |
| JHX98_RS00345 (JHX98_00345) | - | 47872..48042 (+) | 171 | WP_011054883.1 | hypothetical protein | - |
| JHX98_RS00350 (JHX98_00350) | - | 48035..48307 (+) | 273 | WP_011054882.1 | hypothetical protein | - |
| JHX98_RS00355 (JHX98_00355) | - | 48440..48856 (+) | 417 | WP_011054881.1 | transcriptional regulator | - |
| JHX98_RS00360 (JHX98_00360) | - | 48946..49398 (+) | 453 | WP_011106637.1 | terminase small subunit | - |
| JHX98_RS00365 (JHX98_00365) | - | 49388..50665 (+) | 1278 | WP_011054879.1 | PBSX family phage terminase large subunit | - |
| JHX98_RS00370 (JHX98_00370) | - | 50681..52213 (+) | 1533 | WP_011106638.1 | phage portal protein | - |
| JHX98_RS00375 (JHX98_00375) | - | 52173..53621 (+) | 1449 | WP_011054877.1 | minor capsid protein | - |
| JHX98_RS00380 (JHX98_00380) | - | 53649..53837 (+) | 189 | WP_011054876.1 | hypothetical protein | - |
| JHX98_RS00385 (JHX98_00385) | - | 53842..54108 (+) | 267 | WP_011054875.1 | hypothetical protein | - |
| JHX98_RS00390 (JHX98_00390) | - | 54276..54845 (+) | 570 | WP_011054874.1 | DUF4355 domain-containing protein | - |
| JHX98_RS00395 (JHX98_00395) | - | 54858..55745 (+) | 888 | WP_002983429.1 | hypothetical protein | - |
| JHX98_RS00400 (JHX98_00400) | - | 55757..56113 (+) | 357 | WP_011054873.1 | phage head-tail connector protein | - |
| JHX98_RS00405 (JHX98_00405) | - | 56124..56402 (+) | 279 | WP_011054872.1 | hypothetical protein | - |
| JHX98_RS00410 (JHX98_00410) | - | 56399..56743 (+) | 345 | WP_011106640.1 | HK97-gp10 family putative phage morphogenesis protein | - |
| JHX98_RS00415 (JHX98_00415) | - | 56747..57106 (+) | 360 | WP_030126588.1 | hypothetical protein | - |
| JHX98_RS00420 (JHX98_00420) | - | 57118..57717 (+) | 600 | WP_011054869.1 | phage major tail protein, TP901-1 family | - |
| JHX98_RS00425 (JHX98_00425) | - | 57771..58226 (+) | 456 | WP_011054868.1 | tail assembly chaperone | - |
| JHX98_RS00430 (JHX98_00430) | - | 58301..58534 (+) | 234 | WP_011054867.1 | hypothetical protein | - |
| JHX98_RS00435 (JHX98_00435) | - | 58549..62931 (+) | 4383 | WP_011054866.1 | tape measure protein | - |
| JHX98_RS00440 (JHX98_00440) | - | 62943..63785 (+) | 843 | WP_011054865.1 | phage tail family protein | - |
| JHX98_RS00445 (JHX98_00445) | - | 63795..65774 (+) | 1980 | WP_011054864.1 | phage tail protein | - |
| JHX98_RS00450 (JHX98_00450) | - | 65771..66778 (+) | 1008 | WP_011054441.1 | hyaluronoglucosaminidase | - |
| JHX98_RS00455 (JHX98_00455) | - | 66788..68803 (+) | 2016 | WP_200221154.1 | gp58-like family protein | - |
| JHX98_RS00460 (JHX98_00460) | - | 68815..69246 (+) | 432 | WP_002983467.1 | DUF1617 family protein | - |
| JHX98_RS00465 (JHX98_00465) | - | 69249..69866 (+) | 618 | WP_032462176.1 | DUF1366 domain-containing protein | - |
| JHX98_RS00470 (JHX98_00470) | - | 69876..70148 (+) | 273 | WP_002986916.1 | hypothetical protein | - |
| JHX98_RS00475 (JHX98_00475) | - | 70145..70372 (+) | 228 | WP_003058873.1 | phage holin | - |
| JHX98_RS00480 (JHX98_00480) | - | 70488..71690 (+) | 1203 | WP_011184057.1 | glucosaminidase domain-containing protein | - |
| JHX98_RS00485 (JHX98_00485) | - | 72012..72527 (+) | 516 | WP_023077389.1 | hypothetical protein | - |
| JHX98_RS00490 (JHX98_00490) | - | 72641..73627 (-) | 987 | WP_011106647.1 | DNA/RNA non-specific endonuclease | - |
| JHX98_RS00495 (JHX98_00495) | prx | 73860..74042 (+) | 183 | WP_011054856.1 | hypothetical protein | Regulator |
| JHX98_RS00500 (JHX98_00500) | plsX | 74281..75288 (+) | 1008 | WP_002987696.1 | phosphate acyltransferase PlsX | - |
| JHX98_RS00505 (JHX98_00505) | - | 75281..75523 (+) | 243 | WP_011888517.1 | phosphopantetheine-binding protein | - |
| JHX98_RS00510 (JHX98_00510) | purC | 75674..76379 (+) | 706 | Protein_68 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| JHX98_RS00515 (JHX98_00515) | - | 76503..80228 (+) | 3726 | WP_094398275.1 | phosphoribosylformylglycinamidine synthase | - |
| JHX98_RS00520 (JHX98_00520) | purF | 80462..81916 (+) | 1455 | WP_011888519.1 | amidophosphoribosyltransferase | - |
| JHX98_RS00525 (JHX98_00525) | purM | 81944..82966 (+) | 1023 | WP_011888520.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| JHX98_RS00530 (JHX98_00530) | purN | 83134..83688 (+) | 555 | WP_002986700.1 | phosphoribosylglycinamide formyltransferase | - |
| JHX98_RS00535 (JHX98_00535) | purH | 83872..85419 (+) | 1548 | Protein_73 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
| JHX98_RS00540 (JHX98_00540) | - | 85478..86602 (-) | 1125 | WP_002987712.1 | CHAP domain-containing protein | - |
Sequence
Protein
Download Length: 60 a.a. Molecular weight: 6927.67 Da Isoelectric Point: 3.9286
>NTDB_id=524310 JHX98_RS00495 WP_011054856.1 73860..74042(+) (prx) [Streptococcus pyogenes strain iGAS376]
MLTYDEFKQAIDDGYITGDTVAIVRKNGQIFDYALPNEEVRNGEVVTYENVEEVLRELDK
MLTYDEFKQAIDDGYITGDTVAIVRKNGQIFDYALPNEEVRNGEVVTYENVEEVLRELDK
Nucleotide
Download Length: 183 bp
>NTDB_id=524310 JHX98_RS00495 WP_011054856.1 73860..74042(+) (prx) [Streptococcus pyogenes strain iGAS376]
ATGCTAACATACGATGAGTTTAAGCAAGCTATTGATGACGGATATATCACAGGCGACACAGTGGCGATCGTGCGCAAAAA
CGGACAGATTTTTGATTATGCGTTGCCGAATGAAGAGGTAAGAAATGGGGAGGTTGTAACATACGAAAATGTGGAAGAAG
TGCTGAGGGAATTAGACAAATAA
ATGCTAACATACGATGAGTTTAAGCAAGCTATTGATGACGGATATATCACAGGCGACACAGTGGCGATCGTGCGCAAAAA
CGGACAGATTTTTGATTATGCGTTGCCGAATGAAGAGGTAAGAAATGGGGAGGTTGTAACATACGAAAATGTGGAAGAAG
TGCTGAGGGAATTAGACAAATAA
Domains
No domain identified.
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| prx | Streptococcus pyogenes MGAS315 |
100 |
100 |
1 |
| prx | Streptococcus pyogenes MGAS8232 |
80 |
100 |
0.8 |
| prx | Streptococcus pyogenes MGAS315 |
78.333 |
100 |
0.783 |
| prx | Streptococcus pyogenes MGAS315 |
75 |
100 |
0.75 |
| prx | Streptococcus pyogenes MGAS315 |
88.372 |
71.667 |
0.633 |
| prx | Streptococcus pyogenes MGAS315 |
87.805 |
68.333 |
0.6 |
| prx | Streptococcus pyogenes MGAS315 |
76.19 |
70 |
0.533 |