Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   JF649_RS04920 Genome accession   NZ_CP066541
Coordinates   977772..978446 (-) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain MGAS270     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 972772..983446
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JF649_RS04895 (JF649_04890) - 973220..973609 (-) 390 WP_011285547.1 cytidine deaminase -
  JF649_RS04900 (JF649_04895) - 974261..974854 (-) 594 WP_021340920.1 class I SAM-dependent methyltransferase -
  JF649_RS04905 (JF649_04900) coaA 975122..976042 (+) 921 WP_010922353.1 type I pantothenate kinase -
  JF649_RS04910 (JF649_04905) rpsT 976096..976344 (+) 249 WP_009881183.1 30S ribosomal protein S20 -
  JF649_RS04915 (JF649_04910) ciaH 976469..977779 (-) 1311 WP_011054528.1 HAMP domain-containing sensor histidine kinase Regulator
  JF649_RS04920 (JF649_04915) ciaR 977772..978446 (-) 675 WP_002984519.1 response regulator transcription factor Regulator
  JF649_RS04925 (JF649_04920) - 978792..981329 (-) 2538 WP_129321893.1 M1 family metallopeptidase -
  JF649_RS04930 (JF649_04925) phoU 981534..982187 (-) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  JF649_RS04935 (JF649_04930) pstB 982255..983013 (-) 759 WP_002993892.1 phosphate ABC transporter ATP-binding protein PstB -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=520694 JF649_RS04920 WP_002984519.1 977772..978446(-) (ciaR) [Streptococcus pyogenes strain MGAS270]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=520694 JF649_RS04920 WP_002984519.1 977772..978446(-) (ciaR) [Streptococcus pyogenes strain MGAS270]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAGGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TCGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366