Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   IGS65_RS06595 Genome accession   NZ_CP066294
Coordinates   1346787..1347509 (-) Length   240 a.a.
NCBI ID   WP_002263984.1    Uniprot ID   A0AAX1K0W7
Organism   Streptococcus mutans strain 27-3     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1341787..1352509
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IGS65_RS06570 (IGS65_006570) sufU 1341822..1342256 (-) 435 WP_002262744.1 Fe-S cluster assembly sulfur transfer protein SufU -
  IGS65_RS06575 (IGS65_006575) - 1342243..1343472 (-) 1230 WP_192072043.1 cysteine desulfurase -
  IGS65_RS06580 (IGS65_006580) sufD 1343477..1344739 (-) 1263 WP_192072042.1 Fe-S cluster assembly protein SufD -
  IGS65_RS06585 (IGS65_006585) sufC 1344777..1345547 (-) 771 WP_002262747.1 Fe-S cluster assembly ATPase SufC -
  IGS65_RS06590 (IGS65_006590) rgpG 1345621..1346781 (-) 1161 WP_002262748.1 rhamnose-glucose polysaccharide biosynthesis protein RgpB -
  IGS65_RS06595 (IGS65_006595) mecA 1346787..1347509 (-) 723 WP_002263984.1 adaptor protein MecA Regulator
  IGS65_RS06600 (IGS65_006600) - 1347599..1348444 (-) 846 WP_002275187.1 undecaprenyl-diphosphate phosphatase -
  IGS65_RS06605 (IGS65_006605) - 1348502..1350403 (-) 1902 WP_192072041.1 DUF2207 domain-containing protein -
  IGS65_RS06610 (IGS65_006610) - 1350556..1352109 (+) 1554 WP_002280734.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28028.63 Da        Isoelectric Point: 4.2340

>NTDB_id=519140 IGS65_RS06595 WP_002263984.1 1346787..1347509(-) (mecA) [Streptococcus mutans strain 27-3]
MEMKQISETTLKITISMEDLEERGMELKDFLIPQEKTEEFFYTVMDELDLPENFKDSGMLSFRVTPRNDRIDVFVTKSEI
NKNLNLEDLSDFDDISKMSPEDFFNTLEETMREKGDAAALDKLAEIEKREEEKTQQEKGETKEKRDYVHFVLDFPNIQQV
ISFAKTVDYDVEASELFKESDAYHMTVLLNLEDKPDYYADLMFARMLEHAGRGTKTRAYLLEHGVQLIKADALQELQMIG

Nucleotide


Download         Length: 723 bp        

>NTDB_id=519140 IGS65_RS06595 WP_002263984.1 1346787..1347509(-) (mecA) [Streptococcus mutans strain 27-3]
ATGGAAATGAAACAAATCAGCGAAACAACATTAAAAATCACCATCAGTATGGAAGATTTAGAAGAAAGAGGTATGGAATT
AAAAGATTTCTTGATTCCGCAGGAAAAGACGGAAGAATTTTTCTATACTGTTATGGATGAGCTGGACTTGCCTGAAAATT
TCAAGGACAGTGGGATGTTAAGCTTTCGAGTAACACCAAGGAATGATCGCATTGATGTTTTTGTCACTAAGTCAGAAATC
AATAAAAATCTTAATTTGGAGGATTTGTCTGATTTTGATGATATTTCAAAAATGTCTCCGGAGGATTTCTTTAATACCTT
GGAGGAAACCATGCGTGAAAAAGGGGATGCTGCAGCTCTGGATAAATTGGCTGAAATTGAAAAAAGAGAAGAAGAGAAGA
CTCAGCAGGAAAAAGGTGAAACTAAGGAAAAAAGAGATTACGTTCACTTTGTGCTGGATTTTCCTAATATTCAGCAAGTC
ATAAGTTTTGCTAAGACAGTTGACTATGATGTAGAGGCTTCAGAACTTTTTAAGGAGTCTGACGCTTATCACATGACTGT
TCTGCTTAATCTCGAAGATAAACCTGACTATTATGCTGATCTTATGTTTGCAAGAATGTTGGAGCATGCTGGTAGAGGAA
CAAAGACACGTGCTTATCTATTAGAACATGGAGTTCAGCTCATTAAAGCAGATGCTCTGCAAGAATTACAAATGATTGGA
TAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-236)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

99.583

100

0.996
  mecA Streptococcus thermophilus LMD-9

57.787

100

0.588
  mecA Streptococcus thermophilus LMG 18311

57.377

100

0.583
  mecA Streptococcus pneumoniae Rx1

48.571

100

0.496
  mecA Streptococcus pneumoniae D39

48.571

100

0.496
  mecA Streptococcus pneumoniae R6

48.571

100

0.496
  mecA Streptococcus pneumoniae TIGR4

48.571

100

0.496